UBE2V2 - ubiquitin conjugating enzyme E2 V2 Gene

Homo sapiens

Also known as MMS2; UEV2; EDPF1; UEV-2; DDVIT1; EDAF-1; EDPF-1; DDVit-1

Gene ID: 7336 | Gene type: protein coding

About UBE2V2

Cytogenetic location: 8q11.21 Genomic coordinates (GRCh38): 8:47,997,437-48,064,708 (from NCBI)

This gene has 8 transcripts (splice variants), 194 orthologues and 24 paralogues. Ubiquitous expression in brain (RPKM 22.2), adrenal (RPKM 12.6) and 25 other tissues.

Summary

Ubiquitin-conjugating Enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating Enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating Enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by RefSeq, Jul 2008]

UBE2V2 Products(1)

mRNA	Protein	Name
NM_003350.3	NP_003341.1	ubiquitin-conjugating enzyme E2 variant 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11473255	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA double-strand break processing	IMP IMP: Inferred from mutant phenotype	17349954	GOA
involved in positive regulation of double-strand break repair	IDA IDA: Inferred from direct assay	16129784	GOA
involved in positive regulation of protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	10089880	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of UBC13-MMS2 complex	IDA IDA: Inferred from direct assay	16129784	GOA
part of UBC13-MMS2 complex	IPI IPI: Inferred from physical interaction	11473255	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16129784	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2V2 Protein Structure

UQ_con

0
100
145 a.a.

Protein Preferred Names

Protein Names

ubiquitin-conjugating enzyme E2 variant 2

1 alpha,25-dihydroxyvitamin D3-inducible

Recombinant UBE2V2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71411	UBE2V2 Protein, Human (His)	Q15819 (M1-N145)	≥95%

Related Diseases

Diseases

Alias

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15365	UBE2V2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	UBE2V2	RGD	RGD:727838
Bos taurus	UBE2V2	VGNC	VGNC:36597
Macaca mulatta	UBE2V2	VGNC	VGNC:84133
Mus musculus	UBE2V2	MGD	MGI:1917870
Canis familiaris	UBE2V2	VGNC	VGNC:49665
Others	UBE2V2	NCBI

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