UBE2N - ubiquitin conjugating enzyme E2 N Gene

Homo sapiens

Also known as UBC13; UbcH13; UBCHBEN; HEL-S-71; UbcH-ben; UBCHBEN; UBC13

Gene ID: 7334 | Gene type: protein coding

About UBE2N

Cytogenetic location: 12q22 Genomic coordinates (GRCh38): 12:93,405,684-93,441,947 (from NCBI)

This gene has 6 transcripts (splice variants), 89 orthologues and 24 paralogues. Ubiquitous expression in testis (RPKM 18.8), brain (RPKM 12.2) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008]

UBE2N Products(1)

mRNA	Protein	Name
NM_003348.4	NP_003339.1	ubiquitin-conjugating enzyme E2 N

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11473255	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	16122702	GOA
enables ubiquitin conjugating enzyme activity	IDA IDA: Inferred from direct assay	35927303	GOA
enables ubiquitin conjugating enzyme activity	IMP IMP: Inferred from mutant phenotype	17349954	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	18410486	GOA
enables ubiquitin-protein transferase activator activity	IMP IMP: Inferred from mutant phenotype	17349954	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	20061386	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of DNA double-strand break processing	IMP IMP: Inferred from mutant phenotype	17349954	GOA
involved in T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15125833	GOA
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	35893676	GOA
acts upstream of double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	17349954	GOA
involved in negative regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	35927303	GOA
involved in positive regulation of DNA repair	IMP IMP: Inferred from mutant phenotype	16129784	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	14695475	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	16129784	GOA
involved in positive regulation of double-strand break repair	IDA IDA: Inferred from direct assay	16129784	GOA
involved in positive regulation of intracellular signal transduction	IDA IDA: Inferred from direct assay	11057907	GOA
involved in positive regulation of protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	10089880	GOA
acts upstream of postreplication repair	IMP IMP: Inferred from mutant phenotype	17349954	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	35927303	GOA
involved in protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	16307917	GOA
involved in protein K63-linked ubiquitination	IMP IMP: Inferred from mutant phenotype	25936802	GOA
involved in protein monoubiquitination	IMP IMP: Inferred from mutant phenotype	17349954	GOA
involved in protein polyubiquitination	IMP IMP: Inferred from mutant phenotype	17349954	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of UBC13-MMS2 complex	IDA IDA: Inferred from direct assay	16129784	GOA
part of UBC13-MMS2 complex	IPI IPI: Inferred from physical interaction	11057907	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19340006	GOA
located in cytosol	IDA IDA: Inferred from direct assay	16129784	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16129784	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	22797923	GOA
part of ubiquitin conjugating enzyme complex	IDA IDA: Inferred from direct assay	17349954	GOA
part of ubiquitin ligase complex	IDA IDA: Inferred from direct assay	16307917	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2N Protein Structure

UQ_con

0
100
152 a.a.

Protein Preferred Names

Protein Names

ubiquitin-conjugating enzyme E2 N

E2 ubiquitin-conjugating enzyme N

UBE2N Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	UBE2N	P61088	HLTF	Homo sapiens	Q14527	Pull Down	18719106
Intra	UBE2N	P61088	UBE2V1	Homo sapiens	Q13404	Ubiquitinase Assay	25260751
Intra	UBE2N	P61088	UBE2V1	Homo sapiens	Q13404	Pull Down	16307917
Intra	UBE2N	P61088	UBE2V1	Homo sapiens	Q13404	Y2H	19549727
Intra	UBE2N	P61088	UBE2V1	Homo sapiens	Q13404	SLCA	11057907
Cross	UBE2N	P61088	ORF169b	Shigella flexneri	Q8VSD5	Deamination	22407319
Intra	UBE2N	P61088	RFWD3	Homo sapiens	Q6PCD5	Ubiquitinase Assay	25260751
Intra	UBE2N	P61088	RNF13	Homo sapiens	O43567	Ubiquitinase Assay	25260751
Intra	UBE2N	P61088	RNF13	Homo sapiens	O43567	Y2H Array	19690564
Intra	UBE2N	P61088	ZNRF1	Homo sapiens	Q8ND25	TAP	27173435
Intra	UBE2N	P61088	ZNRF1	Homo sapiens	Q8ND25	Y2H Array	19690564
Intra	UBE2N	P61088	RNF182	Homo sapiens	Q8N6D2	Ubiquitinase Assay	25260751
Cross	UBE2N	P61088	otub-1	Caenorhabditis elegans	Q9XVR6	X-Ray Diffraction	22367539
Cross	UBE2N	P61088	otub-1	Caenorhabditis elegans	Q9XVR6	FPS	22367539
Intra	UBE2N	P61088	STUB1	Homo sapiens	Q9UNE7	Pull Down	16307917
Intra	UBE2N	P61088	STUB1	Homo sapiens	Q9UNE7	Ubiquitinase Assay	25260751
Intra	UBE2N	P61088	TRAF6	Homo sapiens	Q9Y4K3	Y2H Array	19549727
Intra	UBE2N	P61088	TRAF6	Homo sapiens	Q9Y4K3	TAP	27173435
Intra	UBE2N	P61088	TRAF6	Homo sapiens	Q9Y4K3	Enzymatic Study	19549727
Intra	UBE2N	P61088	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	19690564
Intra	UBE2N	P61088	RNF11	Homo sapiens	Q9Y3C5	Y2H	15231748
Intra	UBE2N	P61088	XIAP	Homo sapiens	P98170	Enzymatic Study	19549727
Intra	UBE2N	P61088	XIAP	Homo sapiens	P98170	Y2H Array	19549727
Intra	UBE2N	P61088	XIAP	Homo sapiens	P98170	Ubiquitinase Assay	25260751
Intra	UBE2N	P61088	BIRC3	Homo sapiens	Q13489	Y2H Array	19690564
Intra	UBE2N	P61088	BIRC3	Homo sapiens	Q13489	Ubiquitinase Assay	25260751
Intra	UBE2N	P61088	UBE2V2	Homo sapiens	Q15819	TAP	27173435
Intra	UBE2N	P61088	UBE2V2	Homo sapiens	Q15819	Y2H	19549727
Intra	UBE2N	P61088	UBE2V2	Homo sapiens	Q15819	X-Ray Diffraction	11473255
Intra	UBE2N	P61088	LRSAM1	Homo sapiens	Q6UWE0	Ubiquitinase Assay	25260751
Intra	UBE2N	P61088	LRSAM1	Homo sapiens	Q6UWE0	Y2H Array	19690564
Intra	UBE2N	P61088	TRIM32	Homo sapiens	Q13049	TAP	27173435
Intra	UBE2N	P61088	RNF168	Homo sapiens	Q8IYW5	Anti Bait CoIP	19203578

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBE2N Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79452	UBE2N/Ubc13 Protein, Human (sf9, His, Strep)	P61088 (A2-I152)	≥95%

Related Diseases

Diseases

Alias

Riddle Syndrome

RIDL	Radiosensitivity-Immunodeficiency-Dysmorphic Features-Learning Difficulties Syndrome
Rnf168 Deficiency	Radiosensitivity, Immunodeficiency, Dysmorphic Facial Features, And Learning Difficulties
Radiosensitivity, Immunodeficiency, Dysmorphic Features, And Learning Difficulties

Machado-Joseph Disease

SCA3	MJD
Spinocerebellar Ataxia 3	Azorean Disease
Spinocerebellar Ataxia Type 3	Spinocerebellar Atrophy
Azorean Neurologic Disease	Spinopontine Atrophy
Nigrospinodentatal Degeneration	Spinocerebellar Atrophy Iii
Spinocerebellar Atrophy Type 3	Azorean Ataxia
Azorean Disease Of The Nervous System	Machado Disease
Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia	Disease, Machado-Joseph
Ataxia, Spinocerebellar

Limb-Girdle Muscular Dystrophy

Lgmd	Limb Girdle Muscular Dystrophy
Muscular Dystrophies, Limb-Girdle	Erb'S Muscular Dystrophy
Leyden-Mbius Muscular Dystrophy	Limb-Girdle Syndrome
Myopathic Limb-Girdle Syndrome	Limb Girdle
Muscular Dystrophy Limb-Girdle	Dystrophy, Muscular, Limb-Girdle
Lgmd - [Limb-Girdle Muscular Dystrophy]	Limb Girdle Muscle Dystrophy
Limb-Girdle Myopathy

Angelman Syndrome

AS	Happy Puppet Syndrome
Happy Puppet Syndrome, Formerly	Puppetlike Syndrome

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13811	NSC697923		99.93%	Unkown
HY-153775	UC-764864	Inhibitor	99.85%	Unkown
HY-RS15356	UBE2N Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	UBE2N	MGD	MGI:1934835
Rattus norvegicus	UBE2N	RGD	RGD:621096
Macaca mulatta	UBE2N	VGNC	VGNC:100116
Bos taurus	UBE2N	VGNC	VGNC:36590
Others	UBE2N	NCBI

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