UQCRC1 - ubiquinol-cytochrome c reductase core protein 1 Gene

Homo sapiens

Also known as QCR1; PKNPY; UQCR1; D3S3191

Gene ID: 7384 | Gene type: protein coding

About UQCRC1

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,599,002-48,609,646 (from NCBI)

This gene has 10 transcripts (splice variants), 212 orthologues, 6 paralogues and is associated with 1 phenotype. Ubiquitous expression in heart (RPKM 170.6), kidney (RPKM 96.0) and 25 other tissues.

Summary

Enables ubiquitin protein Ligase binding activity. Predicted to be involved in Oxidative Phosphorylation. Predicted to act upstream of or within mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. Implicated in Alzheimer's disease. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2022]

UQCRC1 Products(1)

mRNA	Protein	Name
NM_003365.3	NP_003356.2	cytochrome b-c1 complex subunit 1, mitochondrial precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32161263	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	19725078	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	28844695	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UQCRC1 Protein Structure

Peptidase_M16

Peptidase_M16_C

0
100
200
300
400
480 a.a.

Protein Preferred Names

Protein Names

cytochrome b-c1 complex subunit 1, mitochondrial

complex III subunit 1

UQCRC1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	UQCRC1	P31930	C2orf15	Homo sapiens	Q8WU43	Validated Y2H	32814053
Intra	UQCRC1	P31930	C2orf15	Homo sapiens	Q8WU43	Y2H Array	32814053
Intra	UQCRC1	P31930	C2orf15	Homo sapiens	Q8WU43	Y2H Pooling	32814053
Intra	UQCRC1	P31930	THAP3	Homo sapiens	Q8WTV1	Validated Y2H	32814053
Intra	UQCRC1	P31930	THAP3	Homo sapiens	Q8WTV1	Y2H Array	32814053
Intra	UQCRC1	P31930	THAP3	Homo sapiens	Q8WTV1	Y2H Pooling	32814053
Intra	UQCRC1	P31930	CCNJL	Homo sapiens	Q8IV13	Validated Y2H	32814053
Intra	UQCRC1	P31930	CCNJL	Homo sapiens	Q8IV13	Y2H Pooling	32814053
Intra	UQCRC1	P31930	CCNJL	Homo sapiens	Q8IV13	Y2H Array	32814053
Intra	UQCRC1	P31930	MIER1	Homo sapiens	Q8N108-16	Y2H Array	32814053
Intra	UQCRC1	P31930	MIER1	Homo sapiens	Q8N108-16	Validated Y2H	32814053
Intra	UQCRC1	P31930	MIER1	Homo sapiens	Q8N108-16	Y2H Pooling	32814053
Intra	UQCRC1	P31930	NPHP1	Homo sapiens	C9J082	Y2H Pooling	32814053
Intra	UQCRC1	P31930	NPHP1	Homo sapiens	C9J082	Validated Y2H	32814053
Intra	UQCRC1	P31930	NPHP1	Homo sapiens	C9J082	Y2H Array	32814053
Intra	UQCRC1	P31930	ARHGDIB	Homo sapiens	P52566	Y2H Pooling	32814053
Intra	UQCRC1	P31930	ARHGDIB	Homo sapiens	P52566	Validated Y2H	32814053
Intra	UQCRC1	P31930	ARHGDIB	Homo sapiens	P52566	Y2H Array	32814053
Intra	UQCRC1	P31930	PRMT5	Homo sapiens	O14744	Y2H Array	32814053
Intra	UQCRC1	P31930	PRMT5	Homo sapiens	O14744	Validated Y2H	32814053
Intra	UQCRC1	P31930	PRMT5	Homo sapiens	O14744	Y2H Pooling	32814053
Intra	UQCRC1	P31930	ZNF232	Homo sapiens	Q9UNY5	Validated Y2H	32814053
Intra	UQCRC1	P31930	ZNF232	Homo sapiens	Q9UNY5	Y2H Array	32814053
Intra	UQCRC1	P31930	ZNF232	Homo sapiens	Q9UNY5	Y2H Pooling	32814053
Intra	UQCRC1	P31930	BECN1	Homo sapiens	Q14457	Y2H Array	32814053
Intra	UQCRC1	P31930	BECN1	Homo sapiens	Q14457	Y2H Pooling	32814053
Intra	UQCRC1	P31930	BECN1	Homo sapiens	Q14457	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Parkinsonism With Polyneuropathy

PKNPY

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Polyneuropathy

Polyneuropathies

Parkinsonism

Parkinsonism-Plus	Idiopathic Parkinsonism
Primary Parkinsonism	Paralysis Agitans Syndrome
Parkinsonian Syndrome	Trembling Paralysis
Paralysis Agitans	Shaking Palsy
Shaking Paralysis

Mitochondrial Complex V Deficiency, Nuclear Type 3

Mitochondrial Complex Iii Deficiency Nuclear Type 5	MC5DN3
Mitochondrial Complex Iii Deficiency, Nuclear Type 5	Mitochondrial Complex V Deficiency Nuclear Type 3
MC3DN5	Mitochondrial Complex V Deficiency, Atp5e Type
Mitochondrial Complex Iii Deficiency, Nuclear 5	Mitochondrial Complex V Deficiency, Nuclear Type 3
Mitochondrial Complex V Deficiency Atp5e Type	Mitochondrial Complex V Deficiency Type 3
Mitochondrial Complex V Deficiency, Nuclear, Type 3

Mitochondrial Complex Iv Deficiency, Nuclear Type 5

Leigh Syndrome, French Canadian Type	Mitochondrial Complex V Deficiency Nuclear Type 4
Cytochrome C Oxidase Deficiency, French Canadian Type	Lsfc
Cox Deficiency, French Canadian Type	MC5DN4
MC4DN5	Cox Deficiency, Saguenay-Lac-Saint-Jean Type
Leigh Syndrome, Saguenay-Lac-Saint-Jean Type	Mitochondrial Complex V Deficiency, Nuclear Type 4
French Canadian Leigh Disease	Leigh Syndrome, French-Canadian Type
Leigh Syndrome , French Canadian Type	Mitochondrial Complex V Deficiency, Atp5a1 Type
French Canadian Type Cox Deficiency	French Canadian Type Cytochrome C Oxidase Deficiency
French Canadian Type Leigh Syndrome	Saguenay Lac Saint Jean Type Cox Deficiency
Saguenay Lac Saint Jean Type Leigh Syndrome	Cox Deficiency, Saguenay Lac Saint Jean Type
Leigh Syndrome, Saguenay Lac Saint Jean Type	Mitochondrial Complex V Deficiency, Nuclear Type 4
Mitochondrial Complex V Deficiency Atp5a1 Type	Mitochondrial Complex V Deficiency Type 4
Mitochondrial Complex V Deficiency, Nuclear, Type 4

Mitochondrial Complex Iii Deficiency

Complex 3 Mitochondrial Respiratory Chain Deficiency	Isolated Coq-Cytochrome C Reductase Deficiency
Ubiquinone-Cytochrome C Oxidoreductase Deficiency

Leber Hereditary Optic Neuropathy, Modifier Of

Leber Optic Atrophy	Leber Hereditary Optic Neuropathy
LHON	Leber'S Hereditary Optic Neuropathy
Leber Optic Atrophy, Susceptibility To	Leber'S Optic Atrophy
LOAM	Loas
Leber'S Disease	Leber'S Optic Neuropathy
Optic Atrophy, Hereditary, Leber	Lhon, Modifier Of
Optic Atrophy, Leber Type	Hereditary Optic Neuroretinopathy
Leber Hereditary Optic Atrophy	Loa
Optic Atrophy Leber Type	Leber Hereditary Optic Neuropathy, Modifier
Leber Hereditary Optic Neuropathy Susceptibility	Modifier Of Leber Hereditary Optic Neuropathy
Lebers Hereditary Optic Neuropathy	Leber Congenital Amaurosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15499	UQCRC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	UQCRC1	RGD	RGD:1303314
Macaca mulatta	UQCRC1	VGNC	VGNC:78729
Mus musculus	UQCRC1	MGD	MGI:107876
Felis catus	UQCRC1	VGNC	VGNC:66848
Bos taurus	UQCRC1	VGNC	VGNC:36695
Canis familiaris	UQCRC1	VGNC	VGNC:48163

Name
Email *

	Sorry, but the email address you supplied was invalid.