TMEM258 - transmembrane protein 258 Gene

Homo sapiens

Also known as Kud; Kuduk; C11orf10

Gene ID: 746 | Gene type: protein coding

About TMEM258

Cytogenetic location: 11q12.2 Genomic coordinates (GRCh38): 11:61,788,949-61,792,599 (from NCBI)

This gene has 8 transcripts (splice variants) and 171 orthologues. Ubiquitous expression in colon (RPKM 77.0), stomach (RPKM 64.2) and 25 other tissues.

Summary

Involved in protein N-linked glycosylation. Located in endoplasmic reticulum. Part of oligosaccharyltransferase I complex. [provided by Alliance of Genome Resources, Apr 2022]

TMEM258 Products(1)

mRNA	Protein	Name
NM_014206.4	NP_055021.1	transmembrane protein 258

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28716842	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein N-linked glycosylation	IDA IDA: Inferred from direct assay	31831667	GOA
involved in protein N-linked glycosylation	IMP IMP: Inferred from mutant phenotype	26472760	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12427278	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	26472760	GOA
located in membrane	IDA IDA: Inferred from direct assay	28716842	GOA
part of oligosaccharyltransferase complex	IDA IDA: Inferred from direct assay	26472760	GOA
part of oligosaccharyltransferase complex	IPI IPI: Inferred from physical interaction	31831667	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM258 Protein Structure

Ost5

0
79 a.a.

Protein Preferred Names

Protein Names

transmembrane protein 258

UPF0197 transmembrane protein C11orf10

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia 20

Spinocerebellar Ataxia Type 20	SCA20
Spinocerebellar Ataxia With Dysphonia	Spinocerebellar Ataxia With Spasmodic Cough
Chromosome 11q12 Duplication Syndrome, 260-Kb	Chromosome 11q12 Duplication Syndrome 260-Kb

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14711	TMEM258 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TMEM258	VGNC	VGNC:81204
Rattus norvegicus	TMEM258	RGD	RGD:1560328
Bos taurus	TMEM258	VGNC	VGNC:36066
Mus musculus	TMEM258	MGD	MGI:1916288

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