2. Gene
  3. IER3IP1 - immediate early response 3 interacting protein 1 Gene

IER3IP1 - immediate early response 3 interacting protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MEDS; HSPC039; PRO2309

Gene ID: 51124 | Gene type: protein coding

About IER3IP1

Cytogenetic location: 18q21.1 Genomic coordinates (GRCh38): 18:47,152,834-47,176,364 (from NCBI)

This gene has 2 transcripts (splice variants), 236 orthologues and is associated with 2 phenotypes. Ubiquitous expression in kidney (RPKM 41.1), thyroid (RPKM 27.9) and 25 other tissues.

Summary

This gene encodes a small protein that is localized to the endoplasmic reticulum (ER) and may play a role in the ER stress response by mediating cell differentiation and Apoptosis. Transcription of this gene is regulated by tumor necrosis factor alpha and specificity protein 1 (Sp1). Mutations in this gene may play a role in microcephaly, epilepsy, and diabetes syndrome (MEDS), and a pseudogene of this gene is located on the long arm of chromosome 12. [provided by RefSeq, Dec 2011]

IER3IP1 Products(1)

mRNA Protein Name
NM_016097.5 NP_057181.1 immediate early response 3-interacting protein 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in brain development IDA
IDA: Inferred from direct assay
33122427 GOA
involved in organ growth IDA
IDA: Inferred from direct assay
33122427 GOA
involved in positive regulation of extracellular matrix constituent secretion IMP
IMP: Inferred from mutant phenotype
33122427 GOA
involved in positive regulation of protein secretion IMP
IMP: Inferred from mutant phenotype
33122427 GOA
involved in regulation of fibroblast apoptotic process IMP
IMP: Inferred from mutant phenotype
21835305 GOA
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
15276200 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IER3IP1 Protein Structure

Yos1

Yos1: Yos1-like (5 - 82)

  • 0
  • 82 a.a.
Protein Preferred Names Protein Names

immediate early response 3-interacting protein 1

IER3IP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
IER3IP1 Q9Y5U9 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 CERS2 Homo sapiens Q96G23
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 CERS2 Homo sapiens Q96G23
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 DPM3 Homo sapiens Q9P2X0-2
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 DPM3 Homo sapiens Q9P2X0-2
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 POMK Homo sapiens Q9H5K3
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 POMK Homo sapiens Q9H5K3
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 TMEM80 Homo sapiens Q96HE8
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 TMEM80 Homo sapiens Q96HE8
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 TMEM258 Homo sapiens P61165
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 TMEM258 Homo sapiens P61165
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 PLP1 Homo sapiens P60201-2
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 PLP1 Homo sapiens P60201-2
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 TM4SF18 Homo sapiens Q96CE8
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 TM4SF18 Homo sapiens Q96CE8
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 SLC30A4 Homo sapiens O14863
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 SLC30A4 Homo sapiens O14863
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 GJB1 Homo sapiens P08034
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 GJB1 Homo sapiens P08034
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 PIGP Homo sapiens P57054
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 PIGP Homo sapiens P57054
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 TRHR Homo sapiens P34981
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 TRHR Homo sapiens P34981
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 C19orf18 Homo sapiens Q8NEA5
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 C19orf18 Homo sapiens Q8NEA5
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 FAM210B Homo sapiens Q96KR6
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 FAM210B Homo sapiens Q96KR6
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 TMEM86B Homo sapiens Q8N661
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 CERS4 Homo sapiens Q9HA82
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 CERS4 Homo sapiens Q9HA82
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 TMEM14A Homo sapiens Q9Y6G1
Validated Y2H
32296183
Intra
IER3IP1 Q9Y5U9 HERPUD2 Homo sapiens Q9BSE4
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 HERPUD2 Homo sapiens Q9BSE4
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 ZFYVE27 Homo sapiens Q5T4F4
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 ZFYVE27 Homo sapiens Q5T4F4
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 PEX12 Homo sapiens O00623
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 PEX12 Homo sapiens O00623
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 KCNA1 Homo sapiens Q09470
Y2H Array
32296183
Intra
IER3IP1 Q9Y5U9 KCNA1 Homo sapiens Q09470
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
IER3IP1 Q9Y5U9 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Microcephaly, Epilepsy, And Diabetes Syndrome 1

Microcephaly, Epilepsy, And Diabetes Syndrome

MEDS1

Meds

Microcephaly, Epilepsy, Diabetes Syndrome
Primary Microcephaly-Epilepsy-Permanent Neonatal Diabetes Syndrome
Benign Epilepsy With Centrotemporal Spikes

Rolandic Epilepsy

Benign Rolandic Epilepsy

Epilepsy, Rolandic

Bcects

Benign Childhood Epilepsy With Centrotemporal Spike

Sylvan Seizures

Becrs

Bects

Bre

Benign Epilepsy Of Childhood With Centrotemporal Spikes

Benign Familial Epilepsy Of Childhood With Rolandic Spikes

Centrotemporal Epilepsy
Epilepsy

Epilepsy Syndrome

Epileptic Syndrome

Epilepsies

Symptomatic Epilepsies

Post Traumatic Epilepsy

Traumatic Epilepsy

Traumatic Epileptic

Epilepsy Due To Hippocampal Sclerosis

Epilepsy With Ammon'S Horn Sclerosis

Epilepsy Due To Cortical Dysplasia

Epilepsy Due To Neuronal Migration Disorders
Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus

Wolcott-Rallison Syndrome

Med-Iddm Syndrome

Iddm-Med Syndrome

Wolcott Rallison Syndrome

WRS

Epiphyseal Dysplasia Multiple With Early-Onset Diabetes Mellitus

Early-Onset Diabetes Mellitus With Multiple Epiphyseal Dysplasia

Multiple Epiphyseal Dysplasia With Early-Onset Diabetes Mellitus
Mehmo Syndrome

Mental Retardation, Epileptic Seizures, Hypogonadism And Hypogenitalism, Microcephaly, And Obesity

MEHMO

Mrxs20

Mrxs25

X-Linked Intellectual Disability-Epileptic Seizures-Hypogenitalism-Microcephaly-Obesity Syndrome

Mrxsbrk

Mental Retardation, X-Linked, Syndromic 20

Mental Retardation, X-Linked, Syndromic 25

Mental Retardation, X-Linked, Syndromic, Borck Type

Syndromic X-Linked Mental Retardation 20

Syndromic X-Linked Mental Retardation 25

Intellectual Disability, Epileptic Seizures, Hypogonadism And Hypogenitalism, Microcephaly, And Obesity

X-Linked Mehmo Syndrome
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Thiamine-Responsive Megaloblastic Anemia Syndrome

TRMA

Rogers Syndrome

Thiamine-Responsive Myelodysplasia

Thiamine-Responsive Anemia Syndrome

Thiamine Metabolism Dysfunction Syndrome 1

Thmd1

Megaloblastic Anemia, Thiamine-Responsive, With Diabetes Mellitus And Sensorineural Deafness

Thiamine-Responsive Megaloblastic Anemia With Diabetes Mellitus And Sensorineural Deafness

Thiamine Responsive Megaloblastic Anemia Syndrome

Megaloblastic Anemia Thiamine-Responsive With Diabetes Mellitus And Sensorineural Deafness

Thiamine-Responsive Megaloblastic Anemia

Thiamine-Responsive Anaemia Syndrome

Thiamine-Responsive Megaloblastic Anaemia Syndrome

Thiamine-Responsive Megaloblastic Anaemia With Diabetes Mellitus And Sensorineural Deafness

Thiamine-Responsive Megaloblastic Anemia With Diabetes Mellitus And Sensorineural Hearing Loss
Permanent Neonatal Diabetes Mellitus

Pndm

Permanent Diabetes Mellitus Of Infancy

Pdmi

Neonatal Diabetes Mellitus, Permanent
Diabetes Mellitus, Neonatal, With Congenital Hypothyroidism

Neonatal Diabetes Mellitus With Congenital Hypothyroidism

Ndh Syndrome

NDH

Neonatal Diabetes-Congenital Hypothyroidism-Congenital Glaucoma-Hepatic Fibrosis-Polycystic Kidneys Syndrome
Neonatal Diabetes

Neonatal Diabetes Mellitus

Diabetes Mellitus Syndrome In Newborn Infant

Ndm
Caspase 8 Deficiency

Autoimmune Lymphoproliferative Syndrome Type 2b

Caspase-8 Deficiency

Ceds

Alps2b

Autoimmune Lymphoproliferative Syndrome, Type Iib

Alps With Recurrent Viral Infections

Autoimmune Lymphoproliferative Syndrome With Recurrent Viral Infections

Caspase 8 Deficiency Syndrome

Caspase 8 Lymphadenopathy Syndrome

Autoimmune Lymphoproliferative Syndrome Type Iib

Caspase Eight Deficiency State

CASP8D
Transient Neonatal Diabetes Mellitus

Diabetes Mellitus, Transient Neonatal

Tndm

Chromosome 6-Associated Transient Diabetes Mellitus

Dmtn

Diabetes Mellitus, 6q24-Related Transient Neonatal

Tndm1

Neonatal Diabetes Mellitus, Transient

Tndm -[Transient Neonatal Diabetes Mellitus]
Wolfram Syndrome 2

WFS2
Intestinal Atresia
Megaloblastic Anemia

Imerslund-Grasbeck Syndrome

Igs

Defect Of Enterocyte Intrinsic Factor Receptor

Enterocyte Cobalamin Malabsorption

Familial Megaloblastic Anemia

Megaloblastic Anemia 1

Selective Cobalamin Malabsorption With Proteinuria

Imerslund-Gräsbeck Syndrome

Anemia, Megaloblastic

Grasbeck-Imerslund Syndrome

Megaloblastic Anaemia

Mga1 Norwegian Type

Recessive Hereditary Megaloblastic Anaemia 1

Recessive Hereditary Megaloblastic Anemia 1

Rh-Mga1

Gräsbeck-Imerslund Disease

Pernicious Anemia, Juvenile, Due To Selective Intestinal Malabsorption Of Vitamin B12, With Proteinuria

Juvenile Pernicious Anemia With Proteinuria Due To Selective Intestinal Malabsorption Of Vitamin B12

Anemia Megaloblastic

Megaloblastic Anemia Due To Inborn Errors Of Metabolism

3-@Methylglutaconic Aciduria, Type I
Wolfram Syndrome

Didmoad Syndrome

Didmoad

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

Wfs

Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness

Didmoadud

Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome

Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome
Leukoencephalopathy With Vanishing White Matter

Cree Leukoencephalopathy

Vanishing White Matter Disease

Ovarioleukodystrophy

Vanishing White Matter Leukodystrophy

Childhood Ataxia With Central Nervous System Hypomyelinization

Cach

Cach Syndrome

Myelinosis Centralis Diffusa

VWM

Cle

Childhood Ataxia With Central Nervous System Hypomyelination

Childhood Ataxia With Diffuse Central Nervous System Hypomyelination

Cach/Vwm

Cach/Vwm Syndrome

Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter

Cree Leukoencehalopathy

Late Infantile Cach Syndrome

Juvenile Or Adult Cach Syndrome

Congenital Or Early Infantile Cach Syndrome

Leukodystrophy With Vanishing White Matter
Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset
Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly

Mcph

True Microcephaly

Microcephalia Vera

Microcephaly Vera

Microcephaly Primary Hereditary

Microcephaly, Primary, Autosomal Recessive

Primary Microcephaly
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06549 IER3IP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IER3IP1 RGD RGD:1561565
Mus musculus IER3IP1 MGD MGI:1913441