MFSD6 - major facilitator superfamily domain containing 6 Gene

Homo sapiens

Also known as MMR2; hMMR2

Gene ID: 54842 | Gene type: protein coding

About MFSD6

Cytogenetic location: 2q32.2 Genomic coordinates (GRCh38): 2:190,407,576-190,502,314 (from NCBI)

This gene has 10 transcripts (splice variants), 253 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 26.0), thyroid (RPKM 22.9) and 23 other tissues.

Summary

Predicted to enable MHC class I protein binding activity and MHC class I receptor activity. Predicted to be involved in antigen processing and presentation of exogenous peptide antigen via MHC class I. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

MFSD6 Products(9)

mRNA	Protein	Name
NM_001375986.1	NP_001362915.1	major facilitator superfamily domain-containing protein 6 isoform a
NM_001375987.1	NP_001362916.1	major facilitator superfamily domain-containing protein 6 isoform a
NM_001375988.1	NP_001362917.1	major facilitator superfamily domain-containing protein 6 isoform a
NM_001375989.1	NP_001362918.1	major facilitator superfamily domain-containing protein 6 isoform b
NM_001375990.1	NP_001362919.1	major facilitator superfamily domain-containing protein 6 isoform b
NM_001375992.1	NP_001362921.1	major facilitator superfamily domain-containing protein 6 isoform b
NM_001375993.1	NP_001362922.1	major facilitator superfamily domain-containing protein 6 isoform c
NM_001375994.1	NP_001362923.1	major facilitator superfamily domain-containing protein 6 isoform d
NM_017694.4	NP_060164.3	major facilitator superfamily domain-containing protein 6 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MFSD6 Protein Structure

MFS_1_like

MFS_1

0
200
400
600
791 a.a.

Protein Preferred Names

Protein Names

major facilitator superfamily domain-containing protein 6

macrophage MHC class I receptor 2 homolog

Related Diseases

Diseases

Alias

Herpangina

Vesicular Pharyngitis

West Nile Encephalitis

West-Nile Encephalitis	West Nile Fever
West Nile Fever Encephalitis	West Nile Fever With Encephalitis
West-Nile Fever	Encephalitis, West Nile Fever

Salivary Gland Disease

Salivary Gland Disorders	Salivary Gland Diseases
Non-Neoplastic Salivary Gland Disease	Non-Neoplastic Salivary Gland Disorder
Disorder Of Salivary Gland	Lesion Of Salivary Gland Nos

Tetanus Neonatorum

Neonatal Tetanus	NNT
Trismus Neonatorum	Newborn Trismus

Cutaneous Diphtheria

Diphtheria Wound Infection

Parotid Disease

Parotid Diseases

Orchitis

Inflammation Of Testis	Orchititis
Mumps Orchitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08393	MFSD6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MFSD6	VGNC	VGNC:74571
Mus musculus	MFSD6	MGD	MGI:1922925
Felis catus	MFSD6	VGNC	VGNC:63484
Bos taurus	MFSD6	VGNC	VGNC:31441
Rattus norvegicus	MFSD6	RGD	RGD:1562317
Canis familiaris	MFSD6	VGNC	VGNC:43205

Name
Email *

	Sorry, but the email address you supplied was invalid.