CA3 - carbonic anhydrase 3 Gene

Homo sapiens

Also known as Car3; CAIII

Gene ID: 761 | Gene type: protein coding

About CA3

Cytogenetic location: 8q21.2 Genomic coordinates (GRCh38): 8:85,438,859-85,449,040 (from NCBI)

This gene has 3 transcripts (splice variants), 310 orthologues and 14 paralogues. Biased expression in prostate (RPKM 78.7), fat (RPKM 38.8) and 3 other tissues.

Summary

Carbonic Anhydrase III (CAIII) is a member of a multigene family (at least six separate genes are known) that encodes Carbonic Anhydrase isozymes. These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. The expression of the CA3 gene is strictly tissue specific and present at high levels in skeletal muscle and much lower levels in cardiac and smooth muscle. A proportion of carriers of Duchenne muscle dystrophy have a higher CA3 level than normal. The gene spans 10.3 kb and contains seven exons and six introns. [provided by RefSeq, Oct 2008]

CA3 Products(1)

mRNA	Protein	Name
NM_005181.4	NP_005172.1	carbonic anhydrase 3

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables carbonate dehydratase activity	IDA IDA: Inferred from direct assay	18618712	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytosol	IDA IDA: Inferred from direct assay	18618712	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CA3 Protein Structure

Carb_anhydrase

0
100
200
260 a.a.

Protein Preferred Names

Protein Names

carbonic anhydrase 3

CA-III

CA3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CA3	P07451	LXN	Homo sapiens	Q9BS40	Validated Y2H	32296183
Intra	CA3	P07451	HPCAL1	Homo sapiens	P37235	Y2H Prey Pooling	32296183
Intra	CA3	P07451	HPCAL1	Homo sapiens	P37235	Validated Y2H	32296183
Intra	CA3	P07451	HPCAL1	Homo sapiens	P37235	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CA3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7719	Carbonic Anhydrase 3 Protein, Human (His)	NP_005172.1 (A1-K260)	≥95%

Related Diseases

Diseases

Alias

Acute Myocardial Infarction

Cardiac Attack

Heart Attack

Neuromuscular Disease

Neuromuscular Diseases	Neuromuscular Disorders
Neuromuscular Disorder

Intracranial Hypertension, Idiopathic

Pseudotumor Cerebri	Idiopathic Intracranial Hypertension
Benign Intracranial Hypertension	Iih
Benign Intracran. Hypt.

Osteopetrosis, Autosomal Recessive 3

Osteopetrosis With Renal Tubular Acidosis	Marble Brain Disease
OPTB3	Guibaud-Vainsel Syndrome
Carbonic Anhydrase Ii Deficiency	Osteopetrosis, Autosomal Recessive 3, With Renal Tubular Acidosis
Autosomal Recessive Osteopetrosis 3	Carbonic Anhydrase 2 Deficiency
Autosomal Recessive Osteopetrosis 3 With Renal Tubular Acidosis	Osteopetrosis Autosomal Recessive 3
Autosomal Recessive Osteopetrosis Type 3	Guibaud Vainsel Syndrome
Mixed Rta	Mixed Renal Tubular Acidosis
Renal Tubular Acidosis Type 3	Carbonic Anhydrase Ii Deficiency Syndrome
Carbonic Anhydrase Ii Variant	Osteopetrosis, Autosomal Recessive, Type 3
Carbonic Anhydrase 2

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-116790	(-)-Penbutolol	Antagonist	/	Unkown

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-I1070	D-Isoleucine		≥98.0%	Unkown
HY-P3089A	Dendrotoxin K TFA	Inhibitor	≥98.0%	Unkown
HY-100606	l-Pindolol		99.89%	Unkown
HY-121299	m-Chlorophenylbiguanide		/	Unkown
HY-P3089	Dendrotoxin K	Inhibitor	/	Unkown
HY-P3679	Neuropeptide Y (1-24) (human)	Activator	/	Unkown
HY-RS01769	CA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Name
Email *

	Sorry, but the email address you supplied was invalid.