2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor Adrenergic Receptor
  4. l-Pindolol

l-Pindolol  (Synonyms: (-)-Pindolol; (S)-(-)-Pindolol; S-Pindolol)

Cat. No.: HY-100606 Purity: 99.89%
SDS COA Handling Instructions

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l-Pindolol ((-)-pindolol) is a reversible, competitive and orally active 5-HT1A/1B antagonist. l-Pindolol is a partial β-adrenoceptor agonist. l-Pindolol can be used for the research of neurological disease.

For research use only. We do not sell to patients.

l-Pindolol Chemical Structure

l-Pindolol Chemical Structure

CAS No. : 26328-11-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 172 In-stock
Solution
10 mM * 1 mL in DMSO USD 172 In-stock
Solid
5 mg USD 156 In-stock
10 mg USD 250 In-stock
25 mg USD 500 In-stock
50 mg USD 800 In-stock
100 mg   Get quote  
200 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

l-Pindolol Related Antibodies

Top Publications Citing Use of Products

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  • Biological Activity

  • Purity & Documentation

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Description

l-Pindolol ((-)-pindolol) is a reversible, competitive and orally active 5-HT1A/1B antagonist. l-Pindolol is a partial β-adrenoceptor agonist. l-Pindolol can be used for the research of neurological disease[1][2][3].

In Vitro

l-Pindolol (500 nM and 1 μM) antagonizes the hyperpolarizing effect of both 5-carboxamidotryptamine (5-CT; 10 nM) and 5-Hydroxytryptamine (5-HT; 15 μM) by testing the membrane hyperpolarization induced by 5-CT or 5-HT on CA1 pyramidal cells[1].
l-Pindolol (1 nM-100 μM) inhibits the hyperpolarization in the hippocampus of CA1 pyramidal cells that induced by 100 nM 5-CT with an IC50 value of 92 nM[1].
l-Pindolol (1 nM-100 μM) inhibits the hyperpolarization of CA3 neurones induced by 300 nM 5-CT with an IC50 value of 522 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

l-Pindolol Related Antibodies
In Vivo

l-Pindolol (15 mg/kg; i.p., pretreatment before [3H]-WAY 100635 injection) reduces [3H]-WAY 100635 accumulation of 5-HT1A receptor-containing brain areas[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague Dawley rats[1]
Dosage: 15 mg/kg
Administration: Intraperitoneal injection; 15 mg/kg, 20 min acute treatment or 24 h, 16 h and 20 min short-term treatment before [3H]-WAY 100635 injection
Result: Reduced [3H]-WAY 100635 accumulation in 5-HT1A receptor-containing brain areas, but showed no effect on the dorsal raphe nucleus (DRN), and the CA1 and CA3 hippocampal areas.
Molecular Weight

248.32

Formula

C14H20N2O2
CAS No.
Appearance

Solid

Color

Light brown to gray

SMILES

O[C@@H](CNC(C)C)COC1=CC=CC2=C1C=CN2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (402.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0271 mL 20.1353 mL 40.2706 mL
5 mM 0.8054 mL 4.0271 mL 8.0541 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (10.07 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (10.07 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.89%

SDS (252 KB)

COA (248 KB) HNMR (240 KB) LCMS (260 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0271 mL 20.1353 mL 40.2706 mL 100.6765 mL
5 mM 0.8054 mL 4.0271 mL 8.0541 mL 20.1353 mL
10 mM 0.4027 mL 2.0135 mL 4.0271 mL 10.0677 mL
15 mM 0.2685 mL 1.3424 mL 2.6847 mL 6.7118 mL
20 mM 0.2014 mL 1.0068 mL 2.0135 mL 5.0338 mL
25 mM 0.1611 mL 0.8054 mL 1.6108 mL 4.0271 mL
30 mM 0.1342 mL 0.6712 mL 1.3424 mL 3.3559 mL
40 mM 0.1007 mL 0.5034 mL 1.0068 mL 2.5169 mL
50 mM 0.0805 mL 0.4027 mL 0.8054 mL 2.0135 mL
60 mM 0.0671 mL 0.3356 mL 0.6712 mL 1.6779 mL
80 mM 0.0503 mL 0.2517 mL 0.5034 mL 1.2585 mL
100 mM 0.0403 mL 0.2014 mL 0.4027 mL 1.0068 mL
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l-Pindolol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

l-Pindolol26328-11-0(-)-Pindolol (S)-(-)-Pindolol S-Pindolol5-HT ReceptorAdrenergic ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorBeta Receptorreversiblecompetitiveoral5-CT5-HTCA1CA3Inhibitorinhibitorinhibit

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