2. Gene
  3. Sun1 - Sad1 and UNC84 domain containing 1 Gene

Sun1 - Sad1 and UNC84 domain containing 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Unc84a; mKIAA0810; 4632417G13Rik; 5730434D03Rik

Gene ID: 77053 | Gene type: protein coding

About Sun1

Summary

Enables lamin binding activity. Involved in centrosome localization; meiotic attachment of telomere to nuclear envelope; and nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration. Acts upstream of or within homologous chromosome pairing at meiosis. Located in acrosomal membrane and nuclear envelope. Is integral component of nuclear inner membrane. Is expressed in intercostal muscle; spermatocyte; and spermatozoon. Orthologous to human SUN1 (Sad1 and UNC84 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Sun1 Products(7)

mRNA Protein Name
NM_001256115.1 NP_001243044.1 SUN domain-containing protein 1 isoform 2
NM_001256116.2 NP_001243045.1 SUN domain-containing protein 1 isoform 3
NM_001256117.1 NP_001243046.1 SUN domain-containing protein 1 isoform 4
NM_001256118.1 NP_001243047.1 SUN domain-containing protein 1 isoform 5
NM_001359494.1 NP_001346423.1 SUN domain-containing protein 1 isoform 6
NM_001359496.1 NP_001346425.1 SUN domain-containing protein 1 isoform 7
NM_024451.2 NP_077771.1 SUN domain-containing protein 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables lamin binding IDA
IDA: Inferred from direct assay
19933576 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12036294 MGI
Biological Process GO Annotation Evidence Reference Source
involved in centrosome localization IMP
IMP: Inferred from mutant phenotype
19874786 MGI
acts upstream of or within homologous chromosome pairing at meiosis IMP
IMP: Inferred from mutant phenotype
24589552 MGI
acts upstream of or within meiotic attachment of telomere to nuclear envelope IMP
IMP: Inferred from mutant phenotype
30718482 MGI
involved in meiotic attachment of telomere to nuclear envelope IMP
IMP: Inferred from mutant phenotype
24586178 MGI
involved in nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration IMP
IMP: Inferred from mutant phenotype
19874786 MGI
Cellular Component GO Annotation Evidence Reference Source
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
28031483 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
12036294 MGI
located in membrane IDA
IDA: Inferred from direct assay
16380439 MGI
located in nuclear envelope IDA
IDA: Inferred from direct assay
16079285 MGI
located in nuclear inner membrane IDA
IDA: Inferred from direct assay
16380439 MGI
NOT located in nucleolus IDA
IDA: Inferred from direct assay
12036294 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12036294 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SUN domain-containing protein 1

protein unc-84 homolog A

sad1/unc-84 protein-like 1

unc-84 homolog A

Sun1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Sun1 Q9D666 Kash5 Mus musculus Q80VJ8
Y2H
22826121
Cross
Sun1 Q9D666 EMD Homo sapiens P50402
Pull Down
19933576
Cross
Sun1 Q9D666 SYNE2 Homo sapiens Q8WXH0-4
Pull Down
19933576
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14029 SUN1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sun1 NCBI NCBI:23353