2. Gene
  3. ZNF185 - zinc finger protein 185 with LIM domain Gene

ZNF185 - zinc finger protein 185 with LIM domain Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SCELL

Gene ID: 7739 | Gene type: protein coding

About ZNF185

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:152,898,067-152,973,481 (from NCBI)

This gene has 11 transcripts (splice variants), 149 orthologues and 1 paralogue. Biased expression in esophagus (RPKM 112.2), skin (RPKM 20.8) and 4 other tissues.

Summary

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and Apoptosis. This gene encodes a LIM-domain zinc finger protein. The LIM domain is composed of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker. The LIM domain mediates protein:protein interactions. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, May 2010]

ZNF185 Products(10)

mRNA Protein Name
NM_001178106.1 NP_001171577.1 zinc finger protein 185 isoform 1
NM_001178107.1 NP_001171578.1 zinc finger protein 185 isoform 2
NM_001178108.2 NP_001171579.1 zinc finger protein 185 isoform 3
NM_001178109.1 NP_001171580.1 zinc finger protein 185 isoform 5
NM_001178110.1 NP_001171581.1 zinc finger protein 185 isoform 6
NM_001178113.2 NP_001171584.1 zinc finger protein 185 isoform 7
NM_001178115.2 NP_001171586.1 zinc finger protein 185 isoform 9
NM_001388432.2 NP_001375361.1 zinc finger protein 185 isoform 3
NM_001395254.1 NP_001382183.1 zinc finger protein 185 isoform 10
NM_007150.3 NP_009081.2 zinc finger protein 185 isoform 4
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc finger protein 185

P1-A

ZNF185 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ZNF185 O15231 PIH1D2 Homo sapiens Q8WWB5
Validated Y2H
32296183
Intra
ZNF185 O15231 LMO2 Homo sapiens P25791-3
Validated Y2H
32296183
Intra
ZNF185 O15231 LMO2 Homo sapiens P25791-3
Y2H Array
32296183
Intra
ZNF185 O15231 LMO2 Homo sapiens P25791-3
Y2H Prey Pooling
32296183
Intra
ZNF185 O15231 PRR23B Homo sapiens Q6ZRT6
Validated Y2H
32296183
Intra
ZNF185 O15231 HSF2BP Homo sapiens O75031
Validated Y2H
32296183
Intra
ZNF185 O15231 CBX8 Homo sapiens Q9HC52
Validated Y2H
32296183
Intra
ZNF185 O15231 CEP76 Homo sapiens Q8TAP6
Validated Y2H
32296183
Intra
ZNF185 O15231 CEP76 Homo sapiens Q8TAP6
Y2H Array
32296183
Intra
ZNF185 O15231 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
32296183
Intra
ZNF185 O15231 AARSD1 Homo sapiens Q9BTE6-2
Y2H Prey Pooling
32296183
Intra
ZNF185 O15231 AARSD1 Homo sapiens Q9BTE6-2
Validated Y2H
32296183
Intra
ZNF185 O15231 AARSD1 Homo sapiens Q9BTE6-2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mast Cell Neoplasm

Mastocytoma

Mast Cell Proliferative Disease

Mast Cell Tumor

Benign Mastocytoma
Intussusception

Intussusception Of Intestine

Invagination Of Intestine Or Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS16107 ZNF185 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ZNF185 VGNC VGNC:48670
Rattus norvegicus ZNF185 RGD RGD:1586351
Mus musculus ZNF185 MGD MGI:108095
Bos taurus ZNF185 VGNC VGNC:37219
Felis catus ZNF185 VGNC VGNC:67273