CBX8 - chromobox 8 Gene

Homo sapiens

Also known as PC3; RC1

Gene ID: 57332 | Gene type: protein coding

About CBX8

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:79,792,132-79,797,077 (from NCBI)

This gene has 4 transcripts (splice variants), 271 orthologues and 8 paralogues. Ubiquitous expression in testis (RPKM 4.1), placenta (RPKM 2.1) and 25 other tissues.

Summary

Enables methylated histone binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in chromatin and nucleoplasm. Part of PRC1 complex. Biomarker of esophagus squamous cell carcinoma and glioblastoma. [provided by Alliance of Genome Resources, Apr 2022]

CBX8 Products(1)

mRNA	Protein	Name
NM_020649.3	NP_065700.1	chromobox protein homolog 8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables methylated histone binding	IDA IDA: Inferred from direct assay	21029866	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19636380	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of PRC1 complex	IDA IDA: Inferred from direct assay	12167701	GOA
part of PcG protein complex	IDA IDA: Inferred from direct assay	21282530	GOA
located in chromatin	IDA IDA: Inferred from direct assay	19636380	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21282530	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CBX8 Protein Structure

Chromo

0
100
200
300
389 a.a.

Protein Preferred Names

Protein Names

chromobox protein homolog 8

Pc class 3 homolog

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 7

Leber Congenital Amaurosis 18	RP7
Retinitis Pigmentosa 7, Digenic Form	Retinitis Pigmentosa 7 And Digenic Form
Retinitis Pigmentosa 7, Digenic	LCA18
Retinitis Pigmentosa 7 Digenic

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Retinitis Pigmentosa 90

RP90	Retinitis Pigmentosa, Type 90

Root Caries

Cementum Caries

Dental Caries Of Root Surface

Conversion Disorder

Conversion Hysteria Or Reaction	Conversion Hysterical Neurosis
Hysterical Neurosis, Conversion Type	Fnd
Functional Movement Disorder	Functional Neurological Disorder
Dissociative Disorder

Esophagus Squamous Cell Carcinoma

Esophageal Squamous Cell Carcinoma	Oesophagus Squamous Cell Carcinoma
Scc Of Esophagus	Scc Of Oesophagus
Squamous Cell Carcinoma Of The Esophagus	Escc
Esophageal Epidermoid Carcinoma	Squamous Cell Esophageal Cancer
Squamous Cell Carcinoma Of Esophagus

Hypochondriasis

Hypochondriacal Disorder	Hypochondria
Hypochondriacal Neurosis	Illness Anxiety Disorder
Health Anxiety Disorder	Hypochondriacal Reaction

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-141716	SW2_110A	Inhibitor	99.19%	Unkown
HY-RS02015	CBX8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CBX8	MGD	MGI:1353589
Bos taurus	CBX8	VGNC	VGNC:26821
Rattus norvegicus	CBX8	RGD	RGD:1565375
Canis familiaris	CBX8	VGNC	VGNC:38769
Macaca mulatta	CBX8	VGNC	VGNC:99128
Felis catus	CBX8	VGNC	VGNC:60426

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