SLC30A1 - solute carrier family 30 member 1 Gene

Homo sapiens

Also known as ZNT1; ZRC1

Gene ID: 7779 | Gene type: protein coding

About SLC30A1

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:211,571,568-211,579,161 (from NCBI)

This gene has 1 transcript (splice variant), 221 orthologues and 8 paralogues. Ubiquitous expression in liver (RPKM 22.8), duodenum (RPKM 15.1) and 25 other tissues.

Summary

Predicted to enable Calcium Channel Inhibitor activity and zinc ion transmembrane transporter activity. Predicted to be involved in several processes, including cellular divalent inorganic cation homeostasis; inorganic cation transmembrane transport; and negative regulation of transport. Predicted to act upstream of or within in utero embryonic development. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and nuclear membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC30A1 Products(1)

mRNA	Protein	Name
NM_021194.3	NP_067017.2	zinc transporter 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18158319	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in defense response to bacterium	IDA IDA: Inferred from direct assay	32441444	GOA
involved in intracellular zinc ion homeostasis	IDA IDA: Inferred from direct assay	18158319	GOA
involved in zinc ion import into organelle	IDA IDA: Inferred from direct assay	32441444	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	18158319	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	31471319	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	18158319	GOA
located in cytoplasmic vesicle membrane	IDA IDA: Inferred from direct assay	32441444	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	18158319	GOA
located in nuclear membrane	IDA IDA: Inferred from direct assay	18158319	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17349999	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC30A1 Protein Structure

Cation_efflux

0
100
200
300
400
507 a.a.

Protein Preferred Names

Protein Names

zinc transporter 1

solute carrier family 30 (zinc transporter), member 1

SLC30A1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLC30A1	Q9Y6M5	SLC30A2	Homo sapiens	Q9BRI3	BiFC	25657003

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Epidermodysplasia Verruciformis 1

Epidermodysplasia Verruciformis	Epidermodysplasia Verruciformis, Susceptibility To, 1
Lutz-Lewandowsky Epidermodysplasia Verruciformis	EV1
Lewandowsky-Lutz Syndrome	Ev

Acrodermatitis Enteropathica, Zinc-Deficiency Type

Acrodermatitis Enteropathica	AEZ
Enteropathica	Brandt Syndrome
Ae	Acrodermatitis Enteropathica Zinc Deficiency Type
Danbolt-Cross Syndrome	Acrodermatitis Enteropathica, Zinc Deficiency Type
Inherited Zinc Deficiency	Acrodermatitis Enteropathica, Zinc Deficiency
Danbolt-Closs Syndrome	Primary Zinc Malabsorption Syndrome

Ehlers-Danlos Syndrome, Spondylodysplastic Type, 3

Spondylocheirodysplasia, Ehlers-Danlos Syndrome-Like	Scd-Eds
EDSSPD3	Ehlers-Danlos Syndrome Spondylodysplastic Type 3
Ehlers-Danlos Syndrome, Spondylocheirodysplastic Type	Slc39a13-Related Spondylodysplastic Ehlers-Danlos Syndrome
Slc39a13-Related Speds	Slc39a13-Related Spondylodysplastic Eds
Spondylocheirodysplastic Ehlers-Danlos Syndrome	Speds-Slc39a13
Ehlers-Danlos Syndrome-Like Spondylocheirodysplasia	Ehlers-Danlos Syndrome, Spondylodysplastic, Type 3

Superficial Mycosis

Piedra

Steroid-Modified Tinea Infection

Menkes Disease

Copper Transport Disease	Menkes Syndrome
MNK	Kinky Hair Disease
Steely Hair Disease	Menkes Kinky-Hair Syndrome
Mk	Steely Hair Syndrome
Menkea Syndrome	Md
Menkes Kinky Hair Syndrome	Hypocupremia, Congenital
Kinky Hair Syndrome	X-Linked Copper Deficiency
Menkes Kinky Hair Disease

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13178	SLC30A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLC30A1	VGNC	VGNC:46346
Mus musculus	SLC30A1	MGD	MGI:1345281
Rattus norvegicus	SLC30A1	RGD	RGD:61918
Bos taurus	SLC30A1	VGNC	VGNC:34805
Felis catus	SLC30A1	VGNC	VGNC:107941
Macaca mulatta	SLC30A1	VGNC	VGNC:77451
Others	SLC30A1	NCBI

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