CSDE1 - cold shock domain containing E1 Gene

Homo sapiens

Also known as UNR; D1S155E

Gene ID: 7812 | Gene type: protein coding

About CSDE1

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:114,716,916-114,757,984 (from NCBI)

This gene has 53 transcripts (splice variants), 240 orthologues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 208.0), thyroid (RPKM 164.2) and 25 other tissues.

Summary

Enables RNA stem-loop binding activity. Involved in IRES-dependent viral translational initiation; nuclear-transcribed mRNA catabolic process, no-go decay; and stress granule assembly. Located in Golgi apparatus; cytosol; and plasma membrane. Part of CRD-mediated mRNA stability complex. [provided by Alliance of Genome Resources, Apr 2022]

CSDE1 Products(6)

mRNA	Protein	Name
NM_001007553.3	NP_001007554.1	cold shock domain-containing protein E1 isoform 1
NM_001130523.3	NP_001123995.1	cold shock domain-containing protein E1 isoform 3
NM_001242891.2	NP_001229820.1	cold shock domain-containing protein E1 isoform 4
NM_001242892.2	NP_001229821.1	cold shock domain-containing protein E1 isoform 1
NM_001242893.2	NP_001229822.1	cold shock domain-containing protein E1 isoform 2
NM_007158.6	NP_009089.4	cold shock domain-containing protein E1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RISC complex binding	IDA IDA: Inferred from direct assay	32161113	GOA
enables RNA stem-loop binding	IDA IDA: Inferred from direct assay	17947529	GOA
enables lncRNA binding	IPI IPI: Inferred from physical interaction	36354136	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in CRD-mediated mRNA stabilization	IDA IDA: Inferred from direct assay	11051545	GOA
involved in IRES-dependent viral translational initiation	IDA IDA: Inferred from direct assay	17947529	GOA
involved in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA IDA: Inferred from direct assay	11051545	GOA
involved in nuclear-transcribed mRNA catabolic process, no-go decay	IMP IMP: Inferred from mutant phenotype	15314026	GOA
involved in positive regulation of cytoplasmic translation	IDA IDA: Inferred from direct assay	11051545	GOA
involved in positive regulation of translation	IMP IMP: Inferred from mutant phenotype	36354136	GOA
involved in stress granule assembly	IMP IMP: Inferred from mutant phenotype	29395067	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of CRD-mediated mRNA stability complex	IDA IDA: Inferred from direct assay	15314026	GOA
located in cytosol	IDA IDA: Inferred from direct assay	11051545	GOA
part of mCRD-mediated mRNA stability complex	IPI IPI: Inferred from physical interaction	11051545	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSDE1 Protein Structure

CSD

SUZ-C

0
200
400
600
844 a.a.

Protein Preferred Names

Protein Names

cold shock domain-containing protein E1

N-ras upstream gene protein

Related Diseases

Diseases

Alias

Bulbar Polio

Poliomyelitis, Bulbar

Bulbar Poliomyelitis

Persistent Generalized Lymphadenopathy

Pgl	Persistant Generalized Lymphadenopathy

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03225	CSDE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CSDE1	VGNC	VGNC:39650
Macaca mulatta	CSDE1	VGNC	VGNC:71605
Felis catus	CSDE1	VGNC	VGNC:61213
Mus musculus	CSDE1	MGD	MGI:92356
Rattus norvegicus	CSDE1	RGD	RGD:619726
Bos taurus	CSDE1	VGNC	VGNC:27751

Name
Email *

	Sorry, but the email address you supplied was invalid.