CACNB3 - calcium voltage-gated channel auxiliary subunit beta 3 Gene

Homo sapiens

Also known as CAB3; CACNLB3

Gene ID: 784 | Gene type: protein coding

About CACNB3

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:48,814,480-48,828,941 (from NCBI)

This gene has 24 transcripts (splice variants), 280 orthologues and 3 paralogues. Ubiquitous expression in endometrium (RPKM 10.3), ovary (RPKM 7.3) and 21 other tissues.

Summary

This gene encodes a regulatory beta subunit of the voltage-dependent Calcium Channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011]

CACNB3 Products(4)

mRNA	Protein	Name
NM_000725.4	NP_000716.2	voltage-dependent L-type calcium channel subunit beta-3 isoform 1
NM_001206915.2	NP_001193844.1	voltage-dependent L-type calcium channel subunit beta-3 isoform 2
NM_001206916.2	NP_001193845.1	voltage-dependent L-type calcium channel subunit beta-3 isoform 3
NM_001206917.2	NP_001193846.1	voltage-dependent L-type calcium channel subunit beta-3 isoform 4

CACNB3 Protein Structure

VGCC_beta4Aa_N

Guanylate_kin

0
100
200
300
400
484 a.a.

Protein Preferred Names

Protein Names

voltage-dependent L-type calcium channel subunit beta-3

calcium channel, voltage-dependent, beta 3 subunit

CACNB3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CACNB3	P54284	CTBP2	Homo sapiens	P56545-3	Y2H Prey Pooling	32296183
Intra	CACNB3	P54284	CTBP2	Homo sapiens	P56545-3	Validated Y2H	32296183
Intra	CACNB3	P54284	CTBP2	Homo sapiens	P56545-3	Y2H Array	32296183
Intra	CACNB3	P54284	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	32296183
Intra	CACNB3	P54284	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	CACNB3	P54284	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	CACNB3	P54284	CIMIP1	Homo sapiens	Q9H1P6	Validated Y2H	32296183
Intra	CACNB3	P54284	CIMIP1	Homo sapiens	Q9H1P6	Y2H Array	32296183
Intra	CACNB3	P54284	CIMIP1	Homo sapiens	Q9H1P6	Y2H Prey Pooling	32296183
Intra	CACNB3	P54284	MEOX1	Homo sapiens	P50221	Y2H Array	32296183
Intra	CACNB3	P54284	MEOX1	Homo sapiens	P50221	Y2H Prey Pooling	32296183
Intra	CACNB3	P54284	SKIC2	Homo sapiens	Q15477	Y2H Prey Pooling	32296183
Intra	CACNB3	P54284	SKIC2	Homo sapiens	Q15477	Validated Y2H	32296183
Intra	CACNB3	P54284	SKIC2	Homo sapiens	Q15477	Y2H Array	32296183
Intra	CACNB3	P54284	CEP76	Homo sapiens	Q8TAP6	Y2H Prey Pooling	32296183
Intra	CACNB3	P54284	CEP76	Homo sapiens	Q8TAP6	Validated Y2H	32296183
Intra	CACNB3	P54284	CEP76	Homo sapiens	Q8TAP6	Y2H Array	32296183
Intra	CACNB3	P54284	GEM	Homo sapiens	P55040	Validated Y2H	32296183
Intra	CACNB3	P54284	CIAPIN1	Homo sapiens	Q6FI81	Y2H Prey Pooling	32296183
Intra	CACNB3	P54284	CIAPIN1	Homo sapiens	Q6FI81	Y2H Array	32296183
Intra	CACNB3	P54284	CIAPIN1	Homo sapiens	Q6FI81	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia	Arvc
Arvd	Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Arvc Cardiomyopathy	Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia
Arvd/C	Right Ventricular Dysplasia, Arrhythmogenic
Ventricular Dysplasia, Right, Arrhythmogenic	Cardiomyopathy, Ventricular, Right, Arrhythmogenic
Dysplasia, Arrhythmogenic Right Ventricular

Distal Hereditary Motor Neuronopathy Type 2

Distal Hereditary Motor Neuropathy, Type Ii	Distal Hereditary Motor Neuropathy Type 2
Distal Hereditary Motor Neuropathy Type Ii	Hmn Ii
Hmn2	Distal Hereditary Motor Neuronopathy, Type Ii
Distal Spinal Muscular Atrophy Type 2	Dhmn2
Dsma2	Neuropathy, Motor, Distal, Hereditary, Type Ii
Spinal Muscular Atrophy, Jerash Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01807	CACNB3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CACNB3	RGD	RGD:2248
Felis catus	CACNB3	VGNC	VGNC:60308
Canis familiaris	CACNB3	VGNC	VGNC:38646
Bos taurus	CACNB3	VGNC	VGNC:26685
Mus musculus	CACNB3	MGD	MGI:103307
Macaca mulatta	CACNB3	VGNC	VGNC:70511

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