2. Gene
  3. GEM - GTP binding protein overexpressed in skeletal muscle Gene

GEM - GTP binding protein overexpressed in skeletal muscle Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as KIR

Gene ID: 2669 | Gene type: protein coding

About GEM

Cytogenetic location: 8q22.1 Genomic coordinates (GRCh38): 8:94,249,253-94,262,319 (from NCBI)

This gene has 5 transcripts (splice variants), 201 orthologues and 35 paralogues. Broad expression in gall bladder (RPKM 114.4), urinary bladder (RPKM 36.5) and 15 other tissues.

Summary

The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

GEM Products(2)

mRNA Protein Name
NM_005261.4 NP_005252.1 GTP-binding protein GEM
NM_181702.3 NP_859053.1 GTP-binding protein GEM
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables GDP binding IDA
IDA: Inferred from direct assay
17052716 GOA
enables GTP binding IDA
IDA: Inferred from direct assay
17107948 GOA
enables GTPase activity IDA
IDA: Inferred from direct assay
17107948 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
17107948 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12093360 GOA
Biological Process GO Annotation Evidence Reference Source
involved in chromosome organization IMP
IMP: Inferred from mutant phenotype
22964304 GOA
involved in metaphase chromosome alignment IMP
IMP: Inferred from mutant phenotype
22964304 GOA
involved in mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
22964304 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
7912851 GOA
located in midbody IDA
IDA: Inferred from direct assay
22964304 GOA
located in mitotic spindle IDA
IDA: Inferred from direct assay
22964304 GOA
located in spindle midzone IDA
IDA: Inferred from direct assay
22964304 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GEM Protein Structure

Ras

Ras: Ras family (77 - 239)

  • 0
  • 100
  • 200
  • 296 a.a.
Protein Preferred Names Protein Names

GTP-binding protein GEM

GTP-binding mitogen-induced T-cell protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-149906 Trecovirsen Inhibitor / Unkown
HY-149906C Trecovirsen sodium Inhibitor 98.83% Unkown
HY-143411 GEM144 / Unkown
HY-145314 TC113 / Unkown
HY-145441 GEM–IB / Unkown
HY-146540 GEM-5 / Unkown
HY-148827 GEM-231 Inhibitor / Unkown
HY-148827A GEM-231 sodium Inhibitor / Unkown
HY-149906A FITC-Trecovirsen sodium Inhibitor / Unkown
HY-154842 S-Gem / Unkown
HY-154843 C-Gem / Unkown
HY-RS05366 GEM Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GEM MGD MGI:99844
Bos taurus GEM VGNC VGNC:29315
Rattus norvegicus GEM RGD RGD:1307386
Canis familiaris GEM VGNC VGNC:41172
Felis catus GEM VGNC VGNC:62512
Susscrofa domestica GEM NCBI
Macaca mulatta GEM NCBI NCBI:699130
Others GEM NCBI