CIAPIN1 - cytokine induced apoptosis inhibitor 1 Gene

Homo sapiens

Also known as DRE2; CIAE2; PRO0915; Anamorsin

Gene ID: 57019 | Gene type: protein coding

About CIAPIN1

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:57,428,187-57,447,385 (from NCBI)

This gene has 15 transcripts (splice variants) and 222 orthologues. Broad expression in testis (RPKM 38.4), placenta (RPKM 14.2) and 24 other tissues.

Summary

CIAPIN1 is a cytokine-induced inhibitor of Apoptosis with no relation to Apoptosis regulatory molecules of the BCL2 (MIM 151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 is dependent on growth factor stimulation (Shibayama et al., 2004 [PubMed 14970183]).[supplied by OMIM, Mar 2008]

CIAPIN1 Products(3)

mRNA	Protein	Name
NM_001308347.2	NP_001295276.1	anamorsin isoform 2
NM_001308358.2	NP_001295287.1	anamorsin isoform 3
NM_020313.4	NP_064709.2	anamorsin isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 2 iron, 2 sulfur cluster binding	IDA IDA: Inferred from direct assay	27519415	GOA
enables iron ion binding	EXP EXP: Inferred from Experiment	21700214	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16957168	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	16957168	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CIAPIN1 Protein Structure

CIAPIN1

0
100
200
312 a.a.

Protein Preferred Names

Protein Names

anamorsin

fe-S cluster assembly protein DRE2 homolog

CIAPIN1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CIAPIN1	Q6FI81	NDOR1	Homo sapiens	Q9UHB4	Y2H Array	32296183
Intra	CIAPIN1	Q6FI81	NDOR1	Homo sapiens	Q9UHB4	Y2H Array	25416956
Intra	CIAPIN1	Q6FI81	NDOR1	Homo sapiens	Q9UHB4	Y2H Prey Pooling	32296183
Intra	CIAPIN1	Q6FI81	NDOR1	Homo sapiens	Q9UHB4	MAPPIT	32296183
Intra	CIAPIN1	Q6FI81	NDOR1	Homo sapiens	Q9UHB4	Y2H Array	31515488
Intra	CIAPIN1	Q6FI81	NDOR1	Homo sapiens	Q9UHB4	Validated Y2H	32296183
Intra	CIAPIN1	Q6FI81	NDOR1	Homo sapiens	Q9UHB4	Anti Tag CoIP	33961781
Intra	CIAPIN1	Q6FI81	CACNB3	Homo sapiens	P54284	Anti Tag CoIP	33961781
Intra	CIAPIN1	Q6FI81	BOLA2	Homo sapiens	Q9H3K6	Anti Tag CoIP	27519415
Intra	CIAPIN1	Q6FI81	GLRX3	Homo sapiens	O76003	MAPPIT	25416956
Intra	CIAPIN1	Q6FI81	GLRX3	Homo sapiens	O76003	Y2H Array	32296183
Intra	CIAPIN1	Q6FI81	GLRX3	Homo sapiens	O76003	Y2H	21516116
Intra	CIAPIN1	Q6FI81	GLRX3	Homo sapiens	O76003	Y2H Array	29892012
Intra	CIAPIN1	Q6FI81	GLRX3	Homo sapiens	O76003	Y2H Prey Pooling	25416956
Intra	CIAPIN1	Q6FI81	GLRX3	Homo sapiens	O76003	Anti Tag CoIP	25416956
Intra	CIAPIN1	Q6FI81	GLRX3	Homo sapiens	O76003	Anti Tag CoIP	33961781
Intra	CIAPIN1	Q6FI81	GLRX3	Homo sapiens	O76003	Y2H Prey Pooling	32296183
Intra	CIAPIN1	Q6FI81	GLRX3	Homo sapiens	O76003	Anti Tag CoIP	27519415
Intra	CIAPIN1	Q6FI81	MEOX2	Homo sapiens	P50222	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Wolfram Syndrome 2

WFS2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02704	CIAPIN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CIAPIN1	RGD	RGD:1549737
Canis familiaris	CIAPIN1	VGNC	VGNC:39264
Felis catus	CIAPIN1	VGNC	VGNC:103729
Macaca mulatta	CIAPIN1	VGNC	VGNC:71117
Bos taurus	CIAPIN1	VGNC	VGNC:27357
Mus musculus	CIAPIN1	MGD	MGI:1922083

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