CUEDC2 - CUE domain containing 2 Gene

Homo sapiens

Also known as C10orf66; bA18I14.5

Gene ID: 79004 | Gene type: protein coding

About CUEDC2

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:102,423,249-102,432,574 (from NCBI)

This gene has 4 transcripts (splice variants) and 189 orthologues. Ubiquitous expression in brain (RPKM 31.2), heart (RPKM 24.6) and 25 other tissues.

Summary

Predicted to enable ubiquitin binding activity. Acts upstream of or within negative regulation of cytokine production involved in inflammatory response and negative regulation of macrophage cytokine production. Located in cytosol; nuclear membrane; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CUEDC2 Products(1)

mRNA	Protein	Name
NM_024040.3	NP_076945.2	CUE domain-containing protein 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17347654	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of cytokine production involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	24882011	GOA
acts upstream of or within negative regulation of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	24882011	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CUEDC2 Protein Structure

CUE

0
100
200
287 a.a.

Protein Preferred Names

Protein Names

CUE domain-containing protein 2

CUEDC2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CUEDC2	Q9H467	ESR1	Homo sapiens	P03372	Pull Down	17347654
Intra	CUEDC2	Q9H467	PGR	Homo sapiens	P06401	Confocal	17347654
Intra	CUEDC2	Q9H467	PGR	Homo sapiens	P06401	Anti Tag CoIP	17347654
Intra	CUEDC2	Q9H467	PGR	Homo sapiens	P06401	Pull Down	17347654

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hypertrophy Of Breast

Breasts Enlarged	Large Breast
Hypertrophy Of Breast Nos	Hypertrophy Of Male Breast
Hypertrophic Breast	Excessive Development Of Breast
Macromastia	Mastoplastia

Myasthenic Syndrome, Congenital, 5

Endplate Acetylcholinesterase Deficiency	Congenital Myasthenic Syndrome 5
CMS5	Ead
Engel Congenital Myasthenic Syndrome	Myasthenic Syndrome, Congenital, Engel Type
Cms Ic	Congenital Myasthenic Syndrome Type Ic
Congenital Myasthenic Syndrome Type Ic, Formerly	Cms1c, Formerly
Cms Ic, Formerly	Congenital Myasthenic Syndrome Engel Type
End Plate Acetylcholinesterase Deficiency	Synaptic Congenital Myasthenic Syndromes
Cms1c	Cmse
Congenital Myasthenic Syndrome Type 1c	End-Plate Acetylcholinesterase Deficiency
Myasthenic Syndrome, Congenital, Type 5

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03358	CUEDC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CUEDC2	MGD	MGI:1914366
Felis catus	CUEDC2	VGNC	VGNC:61281
Bos taurus	CUEDC2	VGNC	VGNC:55945
Canis familiaris	CUEDC2	VGNC	VGNC:39727
Rattus norvegicus	CUEDC2	RGD	RGD:1308096

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