KCTD15 - potassium channel tetramerization domain containing 15 Gene

Homo sapiens

Gene ID: 79047 | Gene type: protein coding

About KCTD15

Cytogenetic location: 19q13.11 Genomic coordinates (GRCh38): 19:33,794,040-33,815,761 (from NCBI)

This gene has 13 transcripts (splice variants), 258 orthologues and 13 paralogues. Broad expression in skin (RPKM 22.8), endometrium (RPKM 7.8) and 21 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in protein homooligomerization. [provided by Alliance of Genome Resources, Apr 2022]

KCTD15 Products(3)

mRNA	Protein	Name
NM_001129994.2	NP_001123466.1	BTB/POZ domain-containing protein KCTD15 isoform 2
NM_001129995.2	NP_001123467.1	BTB/POZ domain-containing protein KCTD15 isoform 2
NM_024076.3	NP_076981.2	BTB/POZ domain-containing protein KCTD15 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	27152988	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCTD15 Protein Structure

BTB_2

0
100
200
283 a.a.

Protein Preferred Names

Protein Names

BTB/POZ domain-containing protein KCTD15

potassium channel tetramerisation domain containing 15

KCTD15 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KCTD15	Q96SI1	WIPI1	Homo sapiens	Q5MNZ9	Y2H Pooling	16169070
Intra	KCTD15	Q96SI1	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956
Intra	KCTD15	Q96SI1	ATXN1	Homo sapiens	P54253	Y2H Prey Pooling	23275563
Intra	KCTD15	Q96SI1	KCTD1	Homo sapiens	Q719H9	Y2H Prey Pooling	25416956
Intra	KCTD15	Q96SI1	TRIM27	Homo sapiens	P14373	Y2H Pooling	16169070
Intra	KCTD15	Q96SI1	KCTD15	Homo sapiens	Q96SI1	EM	27152988
Intra	KCTD15	Q96SI1	REN	Homo sapiens	P00797	Y2H Pooling	16169070
Intra	KCTD15	Q96SI1	ENSA	Homo sapiens	O43768	Y2H Pooling	16169070
Intra	KCTD15	Q96SI1	KCTD1	Homo sapiens	Q719H9	Y2H Array	25416956
Intra	KCTD15	Q96SI1	KCTD15	Homo sapiens	Q96SI1	GMS	27152988

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Scalp-Ear-Nipple Syndrome

Finlay-Marks Syndrome	Sen Syndrome
SENS	Scalp Ear Nipple Syndrome
Hereditary Syndrome Of Lumpy Scalp, Odd Ears And Rudimentary Nipples	Hereditary Syndrome Of Lumpy Scalp, Odd Ears, And Rudimentary Nipples
Indian Childhood Cirrhosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07192	KCTD15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	KCTD15	VGNC	VGNC:73894
Bos taurus	KCTD15	VGNC	VGNC:30504
Canis familiaris	KCTD15	VGNC	VGNC:42303
Felis catus	KCTD15	VGNC	VGNC:63055
Mus musculus	KCTD15	MGD	MGI:2385276
Rattus norvegicus	KCTD15	RGD	RGD:1583737

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