DSCC1 - DNA replication and sister chromatid cohesion 1 Gene

Homo sapiens

Also known as DCC1

Gene ID: 79075 | Gene type: protein coding

About DSCC1

Cytogenetic location: 8q24.12 Genomic coordinates (GRCh38): 8:119,833,976-119,855,894 (from NCBI)

This gene has 2 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in lymph node (RPKM 3.7), appendix (RPKM 2.3) and 24 other tissues.

Summary

CHTF18 (MIM 613201), CHTF8 (MIM 613202), and DSCC1 are components of an alternative replication factor C (RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003 [PubMed 12766176]; Bermudez et al., 2003 [PubMed 12930902]).[supplied by OMIM, Dec 2009]

DSCC1 Products(1)

mRNA	Protein	Name
NM_024094.3	NP_076999.2	sister chromatid cohesion protein DCC1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to DNA clamp loader activity	IDA IDA: Inferred from direct assay	12930902	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16682347	GOA
contributes to single-stranded DNA helicase activity	IDA IDA: Inferred from direct assay	12930902	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in maintenance of mitotic sister chromatid cohesion	IMP IMP: Inferred from mutant phenotype	16682347	GOA
involved in positive regulation of DNA-directed DNA polymerase activity	IDA IDA: Inferred from direct assay	12930902	GOA
involved in post-translational protein acetylation	IMP IMP: Inferred from mutant phenotype	19907496	GOA
involved in regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	19907496	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Ctf18 RFC-like complex	IDA IDA: Inferred from direct assay	12930902	GOA
located in chromatin	IDA IDA: Inferred from direct assay	16682347	GOA
located in chromosome, centromeric region	IDA IDA: Inferred from direct assay	16682347	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	16682347	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DSCC1 Protein Structure

Dcc1

0
100
200
300
393 a.a.

Protein Preferred Names

Protein Names

sister chromatid cohesion protein DCC1

defective in sister chromatid cohesion 1 homolog

Related Diseases

Diseases

Alias

Amelogenesis Imperfecta, Hypomaturation Type, Iia3

Amelogenesis Imperfecta Hypomaturation Type 2a3	AI2A3
Amelogenesis Imperfecta Hypomaturation Type Iia3	Amelogenesis Imperfecta, Type Iia3
Amelogenesis Imperfecta Type Iia3	Amelogenesis Imperfecta, Hypomaturation Type, 2a3

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04019	DSCC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DSCC1	VGNC	VGNC:51769
Mus musculus	DSCC1	MGD	MGI:1919357
Bos taurus	DSCC1	VGNC	VGNC:28217
Felis catus	DSCC1	VGNC	VGNC:61636
Macaca mulatta	DSCC1	VGNC	VGNC:71894
Rattus norvegicus	DSCC1	RGD	RGD:1561749

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