PLEKHF1 - pleckstrin homology and FYVE domain containing 1 Gene

Homo sapiens

Also known as APPD; LAPF; PHAFIN1; ZFYVE15

Gene ID: 79156 | Gene type: protein coding

About PLEKHF1

Cytogenetic location: 19q12 Genomic coordinates (GRCh38): 19:29,665,461-29,675,477 (from NCBI)

This gene has 4 transcripts (splice variants), 234 orthologues and 13 paralogues. Ubiquitous expression in fat (RPKM 4.0), spleen (RPKM 2.2) and 24 other tissues.

Summary

Enables phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. Involved in endosome organization; positive regulation of autophagy; and protein localization to plasma membrane. Located in lysosome. Colocalizes with endosome. [provided by Alliance of Genome Resources, Apr 2022]

PLEKHF1 Products(1)

mRNA	Protein	Name
NM_024310.5	NP_077286.3	pleckstrin homology domain-containing family F member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatidylinositol-3-phosphate binding	IDA IDA: Inferred from direct assay	22115783	GOA
enables phosphatidylinositol-4-phosphate binding	IDA IDA: Inferred from direct assay	22115783	GOA
enables phosphatidylinositol-5-phosphate binding	IDA IDA: Inferred from direct assay	22115783	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in endosome organization	IMP IMP: Inferred from mutant phenotype	22115783	GOA
involved in positive regulation of autophagy	IDA IDA: Inferred from direct assay	22115783	GOA
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	22115783	GOA
involved in vesicle organization	IMP IMP: Inferred from mutant phenotype	22115783	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
colocalizes with endosome	IDA IDA: Inferred from direct assay	22115783	GOA
located in lysosome	IDA IDA: Inferred from direct assay	22115783	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLEKHF1 Protein Structure

FYVE

0
100
200
279 a.a.

Protein Preferred Names

Protein Names

pleckstrin homology domain-containing family F member 1

PH and FYVE domain-containing protein 1

PLEKHF1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PLEKHF1	Q96S99	L3MBTL3	Homo sapiens	Q96JM7-2	Y2H Prey Pooling	32296183
Intra	PLEKHF1	Q96S99	L3MBTL3	Homo sapiens	Q96JM7-2	Y2H Array	32296183
Intra	PLEKHF1	Q96S99	NPM2	Homo sapiens	Q86SE8-2	Y2H Array	32296183
Intra	PLEKHF1	Q96S99	NPM2	Homo sapiens	Q86SE8-2	Y2H Prey Pooling	32296183
Intra	PLEKHF1	Q96S99	L3MBTL3	Homo sapiens	Q96JM7	Y2H Prey Pooling	25416956
Intra	PLEKHF1	Q96S99	L3MBTL3	Homo sapiens	Q96JM7	Validated Y2H	25416956
Intra	PLEKHF1	Q96S99	L3MBTL3	Homo sapiens	Q96JM7	Y2H Array	25416956
Intra	PLEKHF1	Q96S99	CHIC2	Homo sapiens	Q9UKJ5	Validated Y2H	32296183
Intra	PLEKHF1	Q96S99	CAVIN2	Homo sapiens	O95810	Y2H Array	32296183
Intra	PLEKHF1	Q96S99	CAVIN2	Homo sapiens	O95810	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10687	PLEKHF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PLEKHF1	MGD	MGI:1919537
Macaca mulatta	PLEKHF1	VGNC	VGNC:76085
Felis catus	PLEKHF1	VGNC	VGNC:64224
Bos taurus	PLEKHF1	VGNC	VGNC:33012
Canis familiaris	PLEKHF1	VGNC	VGNC:44675
Rattus norvegicus	PLEKHF1	RGD	RGD:1310544

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