CHIC2 - cysteine rich hydrophobic domain 2 Gene

Homo sapiens

Also known as BTL

Gene ID: 26511 | Gene type: protein coding

About CHIC2

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:54,009,789-54,091,879 (from NCBI)

This gene has 4 transcripts (splice variants), 200 orthologues, 1 paralogue and is associated with 41 phenotypes. Ubiquitous expression in testis (RPKM 2.4), gall bladder (RPKM 1.4) and 25 other tissues.

Summary

This gene encodes a member of the CHIC family of proteins. The encoded protein contains a cysteine-rich hydrophobic (CHIC) motif, and is localized to vesicular structures and the plasma membrane. This gene is associated with some cases of acute myeloid leukemia. [provided by RefSeq, Jul 2008]

CHIC2 Products(1)

mRNA	Protein	Name
NM_012110.4	NP_036242.1	cysteine-rich hydrophobic domain-containing protein 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHIC2 Protein Structure

Erf4

0
100
165 a.a.

Protein Preferred Names

Protein Names

cysteine-rich hydrophobic domain-containing protein 2

BRX-like translocated in leukemia

CHIC2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CHIC2	Q9UKJ5	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	CHIC2	Q9UKJ5	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	CHIC2	Q9UKJ5	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	25416956
Intra	CHIC2	Q9UKJ5	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	CHIC2	Q9UKJ5	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	FLJ13057	Homo sapiens	Q53SE7	Y2H Array	25416956
Intra	CHIC2	Q9UKJ5	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	CHIC2	Q9UKJ5	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Prey Pooling	25416956
Intra	CHIC2	Q9UKJ5	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	LCE3C	Homo sapiens	Q5T5A8	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	LCE3C	Homo sapiens	Q5T5A8	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	CDR2	Homo sapiens	Q01850	Y2H Array	30886144
Intra	CHIC2	Q9UKJ5	CDR2	Homo sapiens	Q01850	Y2H Prey Pooling	25416956
Intra	CHIC2	Q9UKJ5	CDR2	Homo sapiens	Q01850	Validated Y2H	25416956
Intra	CHIC2	Q9UKJ5	CDR2	Homo sapiens	Q01850	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	CDR2	Homo sapiens	Q01850	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	LCN2	Homo sapiens	P80188	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	LCN2	Homo sapiens	P80188	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	LCE5A	Homo sapiens	Q5TCM9	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	LCE5A	Homo sapiens	Q5TCM9	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	LCE1F	Homo sapiens	Q5T754	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	LCE1F	Homo sapiens	Q5T754	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	KRTAP1-1	Homo sapiens	Q07627	Validated Y2H	32296183
Intra	CHIC2	Q9UKJ5	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	ZNF837	Homo sapiens	Q96EG3	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	ZNF837	Homo sapiens	Q96EG3	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	LCE2C	Homo sapiens	Q5TA81	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	LCE2C	Homo sapiens	Q5TA81	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	LCE1C	Homo sapiens	Q5T751	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	LCE1C	Homo sapiens	Q5T751	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	NDUFB7	Homo sapiens	P17568	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	NDUFB7	Homo sapiens	P17568	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	KRTAP2-4	Homo sapiens	Q9BYR9	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	KRTAP2-4	Homo sapiens	Q9BYR9	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	MYF5	Homo sapiens	P13349	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	MYF5	Homo sapiens	P13349	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	GMCL1	Homo sapiens	Q96IK5	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	GMCL1	Homo sapiens	Q96IK5	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	C1QTNF2	Homo sapiens	Q9BXJ5	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	C1QTNF2	Homo sapiens	Q9BXJ5	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	PNMA1	Homo sapiens	Q8ND90	Validated Y2H	25416956
Intra	CHIC2	Q9UKJ5	PNMA1	Homo sapiens	Q8ND90	Y2H Array	25416956
Intra	CHIC2	Q9UKJ5	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	25416956
Intra	CHIC2	Q9UKJ5	ZNF330	Homo sapiens	Q9Y3S2	Validated Y2H	32296183
Intra	CHIC2	Q9UKJ5	CARD10	Homo sapiens	Q9BWT7	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	CARD10	Homo sapiens	Q9BWT7	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	KRTAP5-9	Homo sapiens	P26371	Validated Y2H	25416956
Intra	CHIC2	Q9UKJ5	KRTAP5-9	Homo sapiens	P26371	Y2H Array	25416956
Intra	CHIC2	Q9UKJ5	KRTAP5-9	Homo sapiens	P26371	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	25416956
Intra	CHIC2	Q9UKJ5	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	AXIN2	Homo sapiens	Q9Y2T1	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	AXIN2	Homo sapiens	Q9Y2T1	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	AXIN2	Homo sapiens	Q9Y2T1	Validated Y2H	32296183
Intra	CHIC2	Q9UKJ5	TCF4	Homo sapiens	P15884	Y2H Array	25416956
Intra	CHIC2	Q9UKJ5	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	HOXA1	Homo sapiens	P49639	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	HOXA1	Homo sapiens	P49639	Y2H Pooling	16189514
Intra	CHIC2	Q9UKJ5	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	CBY2	Homo sapiens	Q8NA61	Validated Y2H	25416956
Intra	CHIC2	Q9UKJ5	CBY2	Homo sapiens	Q8NA61	Y2H Array	25416956
Intra	CHIC2	Q9UKJ5	DNAL4	Homo sapiens	O96015	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	DNAL4	Homo sapiens	O96015	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	19060904
Intra	CHIC2	Q9UKJ5	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Pooling	19060904
Intra	CHIC2	Q9UKJ5	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Pooling	16189514
Intra	CHIC2	Q9UKJ5	CATSPER1	Homo sapiens	Q8NEC5	Y2H Pooling	16189514
Intra	CHIC2	Q9UKJ5	PLEKHF1	Homo sapiens	Q96S99	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	PLEKHF1	Homo sapiens	Q96S99	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
Intra	CHIC2	Q9UKJ5	MEOX2	Homo sapiens	P50222	Y2H Array	25416956
Intra	CHIC2	Q9UKJ5	LCE3A	Homo sapiens	Q5TA76	Y2H Array	32296183
Intra	CHIC2	Q9UKJ5	LCE3A	Homo sapiens	Q5TA76	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956
Intra	CHIC2	Q9UKJ5	PLEKHG4	Homo sapiens	Q58EX7	Y2H Prey Pooling	32296183
Intra	CHIC2	Q9UKJ5	PLEKHG4	Homo sapiens	Q58EX7	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

Disseminated Eosinophilic Collagen Disease

Myeloid Leukemia

Myeloid Leukaemia	Leukaemia Myelogenous
Leukemia Myelogenous	Myeloid Granulocytic Leukaemia
Myeloid Granulocytic Leukemia	Non-Lymphocytic Leukemia
Leukemia, Myeloid	Granulocytic Leukaemia
Myelogenous Leukaemia	Myeloid Leukaemia, Unspecified, Without Mention Of Remission

Myeloid And Lymphoid Neoplasms Associated With Pdgfra Rearrangement

Myeloid/Lymphoid Neoplasm Associated With Pdgfra Rearrangement

Myeloid And Lymphoid Neoplasms With Pdgfra Rearrangement

Splenic Flexure Cancer

Ca Splenic Flexure - Colon	Malignant Neoplasm Of Splenic Flexure
Malignant Tumor Of Splenic Flexure	Malignant Neoplasm Of Splenic Flexure Of Colon

Chronic Eosinophilic Leukemia

Pdgfra-Associated Chronic Eosinophilic Leukemia

Endomyocardial Fibrosis

Becker'S Disease	Obscure African Cardiomyopathy
African Endomyocardial Fibrosis	Endomyocardial Sclerosis
EMF	Becker Muscular Dystrophy

Extracutaneous Mastocytoma

Mastocytoma	Mast Cell Neoplasm
Benign Mastocytoma

Sm-Ahnmd

Systemic Mastocytosis With Associated Clonal, Hematologic Non-Mast-Cell Lineage Disease	Systemic Mastocytosis With Associated Clonal Haematological Non-Mast Cell Lineage Disease
Systemic Mastocytosis With Associated Clonal Hematological Non-Mast-Cell Lineage Disease

Restrictive Cardiomyopathy

Familial Restrictive Cardiomyopathy	Cardiomyopathy, Restrictive
Cardiomyopathy, Constrictive	Primary Restrictive Cardiomyopathy
Rcm	Cardiomyopathy Restrictive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02630	CHIC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CHIC2	VGNC	VGNC:27293
Canis familiaris	CHIC2	VGNC	VGNC:39216
Felis catus	CHIC2	VGNC	VGNC:107319
Mus musculus	CHIC2	MGD	MGI:1921527
Rattus norvegicus	CHIC2	RGD	RGD:1309278

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