2. Gene
  3. CENPO - centromere protein O Gene

CENPO - centromere protein O Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CENP-O; MCM21R; ICEN-36

Gene ID: 79172 | Gene type: protein coding

About CENPO

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:24,793,425-24,822,376 (from NCBI)

This gene has 9 transcripts (splice variants) and 187 orthologues. Ubiquitous expression in placenta (RPKM 11.4), testis (RPKM 8.5) and 24 other tissues.

Summary

This gene encodes a component of the interphase centromere complex. The encoded protein is localized to the centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and checkpoint signaling during mitosis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

CENPO Products(3)

mRNA Protein Name
NM_001199803.3 NP_001186732.1 centromere protein O isoform 2
NM_001322101.2 NP_001309030.1 centromere protein O isoform 1
NM_024322.4 NP_077298.1 centromere protein O isoform 1

CENPO Protein Structure

CENP-O

CENP-O: Cenp-O kinetochore centromere component (121 - 197)

  • 0
  • 100
  • 200
  • 300 a.a.
Protein Preferred Names Protein Names

centromere protein O

centromeric protein O

CENPO Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CENPO Q9BU64 NECAB2 Homo sapiens Q7Z6G3-2
Validated Y2H
25416956
Intra
CENPO Q9BU64 NECAB2 Homo sapiens Q7Z6G3-2
Y2H Array
25416956
Intra
CENPO Q9BU64 FOS Homo sapiens Q6FG41
Y2H Prey Pooling
25416956
Intra
CENPO Q9BU64 CENPP Homo sapiens Q6IPU0
Y2H Array
25416956
Intra
CENPO Q9BU64 CENPP Homo sapiens Q6IPU0
Y2H Array
32296183
Intra
CENPO Q9BU64 CENPP Homo sapiens Q6IPU0
Y2H Prey Pooling
25416956
Intra
CENPO Q9BU64 CENPP Homo sapiens Q6IPU0
Validated Y2H
25416956
Intra
CENPO Q9BU64 CENPP Homo sapiens Q6IPU0
Y2H Prey Pooling
32296183
Intra
CENPO Q9BU64 CENPP Homo sapiens Q6IPU0
Anti Tag CoIP
26496610
Intra
CENPO Q9BU64 CENPP Homo sapiens Q6IPU0
Anti Tag CoIP
33961781
Intra
CENPO Q9BU64 DCDC2 Homo sapiens Q9UHG0
Validated Y2H
32296183
Intra
CENPO Q9BU64 DCDC2 Homo sapiens Q9UHG0
Y2H Array
32296183
Intra
CENPO Q9BU64 DCDC2 Homo sapiens Q9UHG0
Y2H Prey Pooling
32296183
Intra
CENPO Q9BU64 FOSB Homo sapiens P53539
Y2H Array
32296183
Intra
CENPO Q9BU64 FOSB Homo sapiens P53539
Y2H Prey Pooling
32296183
Intra
CENPO Q9BU64 CEP170P1 Homo sapiens Q96L14
Validated Y2H
25416956
Intra
CENPO Q9BU64 CEP170P1 Homo sapiens Q96L14
Y2H Prey Pooling
25416956
Intra
CENPO Q9BU64 CEP170P1 Homo sapiens Q96L14
Y2H Pooling
16189514
Intra
CENPO Q9BU64 CEP170P1 Homo sapiens Q96L14
Y2H Pooling
19447967
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Body Mass Index Quantitative Trait Locus 19

Obesity

BMIQ19

Obesity, Susceptibility To

Obesity, Susceptibility To, Bmiq19

Obesity Bmiq19

{Obesity, Susceptibility To, Bmiq19}
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
3-Methylglutaconic Aciduria With Cataracts, Neurologic Involvement And Neutropenia

3-Methylglutaconic Aciduria Type 7

Mga7

3-Methylglutaconic Aciduria Type Vii

Megcann

Mgca7

3-Methylglutaconic Aciduria-Cataract-Neurologic Involvement-Neutropenia Syndrome

3-Methylglutaconic Aciduria With Cataracts, Neurologic Involvement, And Neutropenia
3-Methylglutaconic Aciduria, Type Iv

3-Methylglutaconic Aciduria Type 4

Mga4

MGCA4

3-Methylglutaconic Aciduria Type Iv

Mga, Type Iv

Mga Type Iv

Not Otherwise Specified 3-Mga-Uria Type

3 Alpha Methylglutaconic Aciduria Type Iv

3 Methylglutaconic Aciduria Type Iv
Type 1 Diabetes Mellitus 2

Diabetes Mellitus, Noninsulin-Dependent, 1

Diabetes Mellitus, Insulin-Dependent, 2

IDDM2

Insulin-Dependent Diabetes Mellitus 2

NIDDM1

Diabetes Mellitus, Noninsulin-Dependent 1

T1D2

Type 2 Diabetes Mellitus 1

T2D1

Noninsulin-Dependent Diabetes Mellitus 1

Diabetes Mellitus, Non-Insulin-Dependent, 1

Type 2 Diabetes Mellitus 1, Susceptibility To

Diabetes Mellitus, Insulin-Dependent, Type 2

Diabetes Mellitus, Non-Insulin-Dependent
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02487 CENPO Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CENPO RGD RGD:1590328
Felis catus CENPO VGNC VGNC:60759
Mus musculus CENPO MGD MGI:1923800
Canis familiaris CENPO VGNC VGNC:39110
Bos taurus CENPO VGNC VGNC:27183
Macaca mulatta CENPO VGNC VGNC:71118