Hsf1 - heat shock transcription factor 1 Gene

Rattus norvegicus

Gene ID: 79245 | Gene type: protein coding

About Hsf1

Primary_assembly 7: 108,196,056-108,223,011 forward strand.mRatBN7.2:CM026980.1

This gene has 4 transcripts (splice variants), 178 orthologues, 5 paralogues and is associated with 22 phenotypes. Biased expression in Muscle (RPKM 82.5), Heart (RPKM 65.9) and 9 other tissues.

Summary

Enables several functions, including STAT family protein binding activity; promoter-specific chromatin binding activity; and sequence-specific single stranded DNA binding activity. Involved in several processes, including cellular response to lipid; positive regulation of macromolecule metabolic process; and regulation of inclusion body assembly. Located in chromatin; cytoplasm; and nucleus. Used to study Parkinson's disease; muscular atrophy; and transient cerebral ischemia. Biomarker of Alzheimer's disease; Parkinson's disease; congestive heart failure; cryptorchidism; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human HSF1 (heat shock transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Hsf1 Products(1)

mRNA	Protein	Name
NM_024393.1	NP_077369.1	heat shock factor protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables STAT family protein binding	IPI IPI: Inferred from physical interaction	22426029	RGD
enables heat shock protein binding	IDA IDA: Inferred from direct assay	24285117	RGD
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	26053851	RGD
enables sequence-specific single stranded DNA binding	IDA IDA: Inferred from direct assay	21512157	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to L-glutamine	IEP IEP: Inferred from expression pattern	23055521	RGD
involved in cellular response to amino acid stimulus	IDA IDA: Inferred from direct assay	21512157	RGD
involved in cellular response to amino acid stimulus	IEP IEP: Inferred from expression pattern	24478344	RGD
involved in cellular response to angiotensin	IDA IDA: Inferred from direct assay	24786827	RGD
involved in cellular response to estradiol stimulus	IDA IDA: Inferred from direct assay	21303943	RGD
involved in cellular response to heat	IMP IMP: Inferred from mutant phenotype	21779805	RGD
involved in cellular response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	22426029	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	21540803	RGD
involved in cellular response to nitroglycerin	IEP IEP: Inferred from expression pattern	25626975	RGD
involved in cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	26212861	RGD
involved in cellular response to potassium ion	IEP IEP: Inferred from expression pattern	24478344	RGD
involved in cellular response to radiation	IDA IDA: Inferred from direct assay	21241601	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	21988238	RGD
involved in defense response	IDA IDA: Inferred from direct assay	10959483	RGD
involved in negative regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	22426029	RGD
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24786827	RGD
involved in negative regulation of inclusion body assembly	IMP IMP: Inferred from mutant phenotype	22216146	RGD
involved in positive regulation of apoptotic DNA fragmentation	IMP IMP: Inferred from mutant phenotype	21192280	RGD
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	21192280	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24523537	RGD
involved in positive regulation of inclusion body assembly	IMP IMP: Inferred from mutant phenotype	22216146	RGD
involved in positive regulation of protein modification process	IMP IMP: Inferred from mutant phenotype	22426029	RGD
involved in positive regulation of stress granule assembly	IMP IMP: Inferred from mutant phenotype	30404558	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	25202991	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	25202991	RGD
involved in response to estradiol	IDA IDA: Inferred from direct assay	18997291	RGD
involved in response to hypobaric hypoxia	IEP IEP: Inferred from expression pattern	24590457	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	24465380	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	25903958	RGD
involved in response to peptide	IEP IEP: Inferred from expression pattern	25202991	RGD
involved in response to psychosocial stress	IEP IEP: Inferred from expression pattern	22922217	RGD
involved in response to testosterone	IDA IDA: Inferred from direct assay	18997291	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in euchromatin	IDA IDA: Inferred from direct assay	18997291	RGD
located in heterochromatin	IDA IDA: Inferred from direct assay	18997291	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hsf1 Protein Structure

HSF

Vert_HS_TF

0
100
200
300
400
500
553 a.a.

Protein Preferred Names

Protein Names

heat shock factor protein 1

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145927	NXP800	Inhibitor	99.86%	Phase 1

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19356	Rocaglamide	Inhibitor	99.34%	Unkown
HY-103000	HSF1A	Activator	99.94%	Unkown
HY-100872	KRIBB11	Inhibitor	99.54%	Unkown
HY-N0754	Eupalinolide A	Activator	99.92%	Unkown
HY-149127	Rosolutamide	Activator	99.03%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hsf1	NCBI	NCBI:3297

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