HSF1 - heat shock transcription factor 1 Gene

Homo sapiens

Also known as HSTF1

Gene ID: 3297 | Gene type: protein coding

About HSF1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,291,604-144,314,720 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 178 orthologues and 9 paralogues. Ubiquitous expression in testis (RPKM 49.6), heart (RPKM 24.2) and 25 other tissues.

Summary

The product of this gene is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE). This protein plays a role in the regulation of lifespan. Expression of this gene is repressed by phosphorylation, which promotes binding by heat shock protein 90. [provided by RefSeq, Jul 2017]

HSF1 Products(10)

mRNA	Protein	Name
XM_047421740.1	XP_047277696.1	heat shock factor protein 1 isoform X4
NM_005526.4	NP_005517.1	heat shock factor protein 1
XM_005272317.3	XP_005272374.1	heat shock factor protein 1 isoform X5
XM_011517006.3	XP_011515308.1	heat shock factor protein 1 isoform X7
XM_005272316.4	XP_005272373.1	heat shock factor protein 1 isoform X2
XM_047421741.1	XP_047277697.1	heat shock factor protein 1 isoform X4
XM_047421742.1	XP_047277698.1	heat shock factor protein 1 isoform X5
XM_017013377.3	XP_016868866.1	heat shock factor protein 1 isoform X3
XM_047421743.1	XP_047277699.1	heat shock factor protein 1 isoform X6
XM_005272315.4	XP_005272372.1	heat shock factor protein 1 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	7935471	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	7760831	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	24504023	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8926278	GOA
enables Hsp90 protein binding	IDA IDA: Inferred from direct assay	11583998	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8926278	GOA
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10561509	GOA
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	21085490	GOA
enables general transcription initiation factor binding	IPI IPI: Inferred from physical interaction	11005381	GOA
enables heat shock protein binding	IDA IDA: Inferred from direct assay	9727490	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	7935471	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	26727490	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9222587	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	9222587	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	16278218	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	25963659	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	24504023	GOA
enables translation elongation factor binding	IDA IDA: Inferred from direct assay	16554823	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in MAPK cascade	IDA IDA: Inferred from direct assay	12917326	GOA
involved in cellular response to cadmium ion	IDA IDA: Inferred from direct assay	10359787	GOA
involved in cellular response to copper ion	IDA IDA: Inferred from direct assay	15016915	GOA
involved in cellular response to diamide	IDA IDA: Inferred from direct assay	15016915	GOA
involved in cellular response to gamma radiation	IDA IDA: Inferred from direct assay	26359349	GOA
involved in cellular response to heat	IDA IDA: Inferred from direct assay	7760831	GOA
involved in cellular response to heat	IMP IMP: Inferred from mutant phenotype	8455624	GOA
involved in cellular response to sodium arsenite	IDA IDA: Inferred from direct assay	15016915	GOA
involved in cellular response to unfolded protein	IDA IDA: Inferred from direct assay	15016915	GOA
involved in negative regulation of double-strand break repair via nonhomologous end joining	IMP IMP: Inferred from mutant phenotype	26359349	GOA
involved in negative regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	26359349	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8926278	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	24504023	GOA
involved in positive regulation of macrophage differentiation	IMP IMP: Inferred from mutant phenotype	24504023	GOA
involved in positive regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	18794143	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10561509	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9341107	GOA
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	11583998	GOA
involved in regulation of cellular response to heat	IDA IDA: Inferred from direct assay	11583998	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7760831	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in PML body	IDA IDA: Inferred from direct assay	11514557	GOA
located in centrosome	IDA IDA: Inferred from direct assay	18794143	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	8455624	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	18794143	GOA
located in mitotic spindle pole	IDA IDA: Inferred from direct assay	18794143	GOA
located in nuclear stress granule	IDA IDA: Inferred from direct assay	10359787	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	10359787	GOA
located in nucleus	IDA IDA: Inferred from direct assay	8455624	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	26359349	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	21085490	GOA
part of protein folding chaperone complex	IDA IDA: Inferred from direct assay	8455624	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	16554823	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSF1 Protein Structure

HSF_DNA-bind

Vert_HS_TF

0
100
200
300
400
500
529 a.a.

Protein Preferred Names

Protein Names

heat shock factor protein 1

Recombinant HSF1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73918	HSF1 Protein, Human (His)	Q00613-1 (D2-S529)	≥95%

Related Diseases

Diseases

Alias

Hermansky-Pudlak Syndrome 5

HPS5	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial
Delta Storage Pool Disease	Hermansky-Pudlak Syndrome, Type 5
Platelet Storage Pool Deficiency	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Heat-Shock Rna 1

Hsr1

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Protection Against	Lung Cancer, Susceptibility To
Adenocarcinoma Of Lung, Somatic	Nonsmall Cell Lung Cancer
Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145927	NXP800	Inhibitor	99.79%	Phase 1

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19356	Rocaglamide	Inhibitor	99.34%	Unkown
HY-100872	KRIBB11	Inhibitor	99.54%	Unkown
HY-103000	HSF1A	Activator	99.46%	Unkown
HY-N0754	Eupalinolide A	Activator	99.92%	Unkown
HY-149127	Rosolutamide	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HSF1	VGNC	VGNC:41814
Rattus norvegicus	HSF1	RGD	RGD:620913
Bos taurus	HSF1	VGNC	VGNC:29981
Felis catus	HSF1	VGNC	VGNC:67661
Mus musculus	HSF1	MGD	MGI:96238
Macaca mulatta	HSF1	VGNC	VGNC:73531
Others	HSF1	NCBI

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