ULBP3 - UL16 binding protein 3 Gene

Homo sapiens

Also known as N2DL-3; RAET1N; NKG2DL3

Gene ID: 79465 | Gene type: protein coding

About ULBP3

Cytogenetic location: 6q25.1 Genomic coordinates (GRCh38): 6:150,061,053-150,069,121 (from NCBI)

This gene has 2 transcripts (splice variants), 310 orthologues and 22 paralogues. Broad expression in testis (RPKM 3.9), thyroid (RPKM 2.5) and 17 other tissues.

Summary

The protein encoded by this gene is one of several related ligands of the KLRK1/NKG2D receptor, which is found in primary NK cells. Binding of these ligands to the receptor activates several signal transduction pathways, including the JAK2, STAT5, and ERK pathways. The encoded protein is expressed solubly and on the surface of many tumor cells, making it potentially an important target for therapeutics. [provided by RefSeq, Nov 2015]

ULBP3 Products(1)

mRNA	Protein	Name
NM_024518.3	NP_078794.1	UL16-binding protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables natural killer cell lectin-like receptor binding	IDA IDA: Inferred from direct assay	11239445	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11754823	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in natural killer cell activation	IDA IDA: Inferred from direct assay	11239445	GOA
involved in natural killer cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	11239445	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	11239445	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ULBP3 Protein Structure

MHC_I

0
100
200
244 a.a.

Protein Preferred Names

Protein Names

UL16-binding protein 3

ALCAN-gamma

ULBP3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ULBP3	Q9BZM4	UQCRC1	Homo sapiens	P31930	Validated Y2H	32814053
Intra	ULBP3	Q9BZM4	UQCRC1	Homo sapiens	P31930	Y2H Array	32814053
Intra	ULBP3	Q9BZM4	UQCRC1	Homo sapiens	P31930	Y2H Pooling	32814053
Intra	ULBP3	Q9BZM4	KLRK1	Homo sapiens	P26718	FACS	18544572
Intra	ULBP3	Q9BZM4	KLRK1	Homo sapiens	P26718	X-Ray Diffraction	11754823

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Alopecia Areata

Aa	Alopecia Celsi
Alopecia Circumscripta	Cazenave'S Vitiligo
Celsus' Vitiligo	Diffuse Alopecia
Jonston'S Alopecia	Marginal Alopecia
Pseudopelade	Circumscribed Alopecia
Alopecia Cicatrisata	Patchy Alopecia
Alopecia	Aa - [Alopecia Areata]
Pelade

Alopecia Universalis Congenita

Alopecia Universalis	ALUNC
Atrichia, Generalized	Au
Alopecia Areata Universalis	Atrichia Generalized

Polyomavirus-Associated Nephropathy

Polyomavirus Associated Nephropathy

Pvan

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15450	ULBP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ULBP3	MGD	MGI:3588256
Others	ULBP3	NCBI

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