2. Gene
  3. RNF128 - ring finger protein 128 Gene

RNF128 - ring finger protein 128 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as GRAIL

Gene ID: 79589 | Gene type: protein coding

About RNF128

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:106,693,838-106,797,016 (from NCBI)

This gene has 3 transcripts (splice variants), 227 orthologues and 9 paralogues. Broad expression in small intestine (RPKM 27.8), liver (RPKM 27.8) and 15 other tissues.

Summary

The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin Ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

RNF128 Products(2)

mRNA Protein Name
NM_024539.3 NP_078815.3 E3 ubiquitin-protein ligase RNF128 isoform 2 precursor
NM_194463.2 NP_919445.1 E3 ubiquitin-protein ligase RNF128 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in regulation of protein stability IMP
IMP: Inferred from mutant phenotype
25635054 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF128 Protein Structure

PA

PA: PA domain (118 - 182)

zf-RING_2

zf-RING_2: Ring finger domain (275 - 318)

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  • 400
  • 428 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF128

RING-type E3 ubiquitin transferase RNF128

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12046 RNF128 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RNF128 VGNC VGNC:64668
Macaca mulatta RNF128 VGNC VGNC:76792
Rattus norvegicus RNF128 RGD RGD:1566282
Mus musculus RNF128 MGD MGI:1914139
Bos taurus RNF128 VGNC VGNC:34019
Canis familiaris RNF128 VGNC VGNC:45628