2. Gene
  3. RNF128 - ring finger protein 128 Gene

RNF128 - ring finger protein 128 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as GRAIL

Gene ID: 79589 | Gene type: protein coding

About RNF128

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:106,693,838-106,797,016 (from NCBI)

This gene has 3 transcripts (splice variants), 227 orthologues and 9 paralogues. Broad expression in small intestine (RPKM 27.8), liver (RPKM 27.8) and 15 other tissues.

Summary

The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin Ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

RNF128 Products(2)

mRNA Protein Name
NM_024539.3 NP_078815.3 E3 ubiquitin-protein ligase RNF128 isoform 2 precursor
NM_194463.2 NP_919445.1 E3 ubiquitin-protein ligase RNF128 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in regulation of protein stability IMP
IMP: Inferred from mutant phenotype
25635054 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF128 Protein Structure

PA

PA: PA domain (118 - 182)

zf-RING_2

zf-RING_2: Ring finger domain (275 - 318)

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  • 400
  • 428 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF128

RING-type E3 ubiquitin transferase RNF128

RNF128 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RNF128 Q8TEB7 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
25416956
Intra
RNF128 Q8TEB7 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
32296183
Intra
RNF128 Q8TEB7 CEP76 Homo sapiens Q8TAP6
Y2H Array
32296183
Intra
RNF128 Q8TEB7 APPBP2 Homo sapiens Q92624
Validated Y2H
25416956
Intra
RNF128 Q8TEB7 APPBP2 Homo sapiens Q92624
Y2H Array
25416956
Intra
RNF128 Q8TEB7 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
RNF128 Q8TEB7 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
RNF128 Q8TEB7 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12046 RNF128 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RNF128 VGNC VGNC:64668
Macaca mulatta RNF128 VGNC VGNC:76792
Rattus norvegicus RNF128 RGD RGD:1566282
Mus musculus RNF128 MGD MGI:1914139
Bos taurus RNF128 VGNC VGNC:34019
Canis familiaris RNF128 VGNC VGNC:45628