2. Gene
  3. TNFAIP8L2 - TNF alpha induced protein 8 like 2 Gene

TNFAIP8L2 - TNF alpha induced protein 8 like 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as TIPE2

Gene ID: 79626 | Gene type: protein coding

About TNFAIP8L2

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,156,649-151,159,749 (from NCBI)

This gene has 1 transcript (splice variant), 211 orthologues and 3 paralogues. Broad expression in spleen (RPKM 30.0), lymph node (RPKM 26.2) and 14 other tissues.

Summary

Predicted to be involved in negative regulation of T cell activation and negative regulation of inflammatory response. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TNFAIP8L2 Products(1)

mRNA Protein Name
NM_024575.5 NP_078851.2 tumor necrosis factor alpha-induced protein 8-like protein 2
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22949657 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFAIP8L2 Protein Structure

DUF758

DUF758: Domain of unknown function (DUF758) (1 - 184)

  • 0
  • 100
  • 184 a.a.
Protein Preferred Names Protein Names

tumor necrosis factor alpha-induced protein 8-like protein 2

TNF alpha-induced protein 8-like protein 2

TNFAIP8L2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TNFAIP8L2 Q6P589 RAC1 Homo sapiens P63000
Anti Bait CoIP
24274578
Intra
TNFAIP8L2 Q6P589 RAC2 Homo sapiens P15153
Anti Tag CoIP
22949657
Intra
TNFAIP8L2 Q6P589 RAC1 Homo sapiens P63000-1
Anti Tag CoIP
22949657
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14793 TNFAIP8L2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TNFAIP8L2 VGNC VGNC:36159
Macaca mulatta TNFAIP8L2 VGNC VGNC:79599
Rattus norvegicus TNFAIP8L2 RGD RGD:1310519
Mus musculus TNFAIP8L2 MGD MGI:1917019
Canis familiaris TNFAIP8L2 VGNC VGNC:47653
Felis catus TNFAIP8L2 VGNC VGNC:66401