PPP1R3B - protein phosphatase 1 regulatory subunit 3B Gene

Homo sapiens

Also known as GL; PTG; PPP1R4

Gene ID: 79660 | Gene type: protein coding

About PPP1R3B

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:9,136,255-9,151,539 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 210 orthologues and 6 paralogues. Broad expression in liver (RPKM 50.1), heart (RPKM 12.4) and 22 other tissues.

Summary

This gene encodes the catalytic subunit of the serine/theonine Phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Jan 2011]

PPP1R3B Products(2)

mRNA	Protein	Name
NM_001201329.2	NP_001188258.1	protein phosphatase 1 regulatory subunit 3B
NM_024607.4	NP_078883.2	protein phosphatase 1 regulatory subunit 3B

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15231748	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of glycogen catabolic process	IDA IDA: Inferred from direct assay	22225877	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1R3B Protein Structure

CBM_21

0
100
200
285 a.a.

Protein Preferred Names

Protein Names

protein phosphatase 1 regulatory subunit 3B

PP1 subunit R4

PPP1R3B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPP1R3B	Q86XI6	PPP1CC	Homo sapiens	P36873	Anti Tag CoIP	33961781
Intra	PPP1R3B	Q86XI6	PPP1CA	Homo sapiens	P62136	Y2H	15231748
Intra	PPP1R3B	Q86XI6	PPP1CA	Homo sapiens	P62136	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Glycogen Storage Disease Vi

Glycogen Storage Disease Type Vi	Hers Disease
GSD6	Gsd Vi
Hepatic Glycogen Phosphorylase Deficiency	Phosphorylase Deficiency Glycogen-Storage Disease Of Liver
Hers' Disease	Glycogen Storage Disease Type 6
Glycogen Storage Disease 6	Gsd Type Vi
Glycogenosis Type Vi	Glycogen Storage Disease, Type Vi
Hepatophosphorylase Deficiency Glycogenosis	Liver Phosphorylase Deficiency Syndrome
Glycogen Storage Disease Due To Liver Glycogen Phosphorylase Deficiency	Gsd Due To Liver Glycogen Phosphorylase Deficiency
Gsd Type 6	Glycogenosis Due To Liver Glycogen Phosphorylase Deficiency
Glycogenosis Type 6	Hepatic Phosphorylase Deficiency
Liver Glycogen Phosphorylase Deficiency	Her
Glycogen Storage Disease Vib	Gsd-Vi
Liver Phosphorylase Deficiency	Storage Disease, Glycogen, Type Vi

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10999	PPP1R3B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PPP1R3B	MGD	MGI:2177268
Rattus norvegicus	PPP1R3B	RGD	RGD:621600
Macaca mulatta	PPP1R3B	VGNC	VGNC:104472
Felis catus	PPP1R3B	VGNC	VGNC:107422
Canis familiaris	PPP1R3B	VGNC	VGNC:44897
Bos taurus	PPP1R3B	VGNC	VGNC:33243

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