ICE2 - interactor of little elongation complex ELL subunit 2 Gene

Homo sapiens

Also known as BRCC1; NARG2

Gene ID: 79664 | Gene type: protein coding

About ICE2

Cytogenetic location: 15q22.2 Genomic coordinates (GRCh38): 15:60,419,609-60,479,142 (from NCBI)

This gene has 17 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in thyroid (RPKM 5.8), ovary (RPKM 4.5) and 25 other tissues.

Summary

This gene encodes a protein component of the little elongation complex (LEC), which plays a role in small nuclear RNA (snRNA) transcription. The LEC regulates snRNA transcription by enhancing both RNA Polymerase II occupancy and transcriptional elongation. The encoded protein and other LEC components have been shown to localize to Cajal bodies, which are sites of ribonucleoprotein (RNP) complex assembly. Pseudogenes of this gene have been identified on chromosomes 3 and 4. [provided by RefSeq, May 2017]

ICE2 Products(3)

mRNA	Protein	Name
NM_001018089.3	NP_001018099.1	little elongation complex subunit 2 isoform b
NM_001276385.2	NP_001263314.1	little elongation complex subunit 2 isoform c
NM_024611.6	NP_078887.2	little elongation complex subunit 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21729782	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase III	IMP IMP: Inferred from mutant phenotype	23932780	GOA
involved in snRNA transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23932780	GOA
involved in snRNA transcription by RNA polymerase III	IMP IMP: Inferred from mutant phenotype	23932780	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Cajal body	IDA IDA: Inferred from direct assay	23932780	GOA
located in euchromatin	IDA IDA: Inferred from direct assay	22195968	GOA
located in histone locus body	IDA IDA: Inferred from direct assay	23932780	GOA
part of transcription elongation factor complex	IDA IDA: Inferred from direct assay	23932780	GOA
part of transcription elongation factor complex	IMP IMP: Inferred from mutant phenotype	22195968	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ICE2 Protein Structure

NARG2_C

0
200
400
600
800
982 a.a.

Protein Preferred Names

Protein Names

little elongation complex subunit 2

NMDA receptor regulated 2

Related Diseases

Diseases

Alias

Monocular Exotropia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-151871	ICeD-2	Inhibitor	/	Unkown
HY-RS06518	ICE2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ICE2	VGNC	VGNC:62868
Macaca mulatta	ICE2	VGNC	VGNC:73459
Mus musculus	ICE2	MGD	MGI:2135947
Rattus norvegicus	ICE2	RGD	RGD:1585038
Canis familiaris	ICE2	VGNC	VGNC:41859
Bos taurus	ICE2	VGNC	VGNC:30027

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