ZYG11B - zyg-11 family member B, cell cycle regulator Gene

Homo sapiens

Also known as ZYG11

Gene ID: 79699 | Gene type: protein coding

About ZYG11B

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:52,726,453-52,827,336 (from NCBI)

This gene has 2 transcripts (splice variants), 271 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 12.1), thyroid (RPKM 8.7) and 25 other tissues.

Summary

Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein quality control for misfolded or incompletely synthesized proteins. Part of Cul2-RING ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

ZYG11B Products(1)

mRNA	Protein	Name
NM_024646.3	NP_078922.1	protein zyg-11 homolog B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17304241	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	31273098	GOA
involved in protein quality control for misfolded or incompletely synthesized proteins	IMP IMP: Inferred from mutant phenotype	31273098	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul2-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	31273098	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein zyg-11 homolog B

zyg-11 homolog B

ZYG11B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZYG11B	Q9C0D3	CUL2	Homo sapiens	Q13617	Anti Tag CoIP	17304241

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Craniofacial Microsomia

Goldenhar Syndrome	Hemifacial Microsomia
Oculoauriculovertebral Spectrum	Oavs
Oculo-Auriculo-Vertebral Spectrum	CFM
Oav Dysplasia	Facioauriculovertebral Sequence
Fav Sequence	First And Second Branchial Arch Syndrome
Otomandibular Dysostosis	Hfm
Oculoauriculovertebral Dysplasia	Facio-Auriculo-Vertebral Spectrum
Facioauriculovertebral Dysplasia	Oculo-Auriculo-Vertebral Dysplasia
First Arch Syndrome	Oav Dysplasia
Goldenhar Disease	Expanded Spectrum Hemifacial Microsomia
Expanded Spectrum Of Hemifacial Microsomia	Oculoauriculovertebral Syndrome
Oavd	Asymmetric Hypoplasia Of Facial Structures
Auriculobranchiogenic Dysplasia	Fav
First And Second Pharyngeal Arch Syndromes	Goldenhar-Gorlin Syndrome
Lateral Facial Dysplasia	Oav Complex
Oral-Mandibular-Auricular Syndrome	Unilateral Intrauterine Facial Necrosis
Unilateral Mandibulofacial Dysostosis	Oav Spectrum
Oculoauricular Vertebral Dysplasia	Microsomia, Hemifacial
Goldenhar Syndrome With Ipsilateral Radial Defect

Cardiomyopathy, Familial Hypertrophic, 26

Hypertrophic Cardiomyopathy 26	CMH26
Cardiomyopathy, Familial Restrictive 5	Cardiomyopathy, Familial Restrictive, 5
Cardiomyopathy Familial Hypertrophic 26	Cardiomyopathy, Familial Hypertrophic 26
RCM5

Noonan Syndrome 12

NS12

Branchiootic Syndrome

Bo Syndrome	Branchiootic Dysplasia
Bor	Bo Syndrome 1
Bos1	Branchiootic Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16214	ZYG11B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ZYG11B	VGNC	VGNC:100197
Felis catus	ZYG11B	VGNC	VGNC:67393
Bos taurus	ZYG11B	VGNC	VGNC:37394
Mus musculus	ZYG11B	MGD	MGI:2685277
Canis familiaris	ZYG11B	VGNC	VGNC:48869
Rattus norvegicus	ZYG11B	RGD	RGD:1307814

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