CUL2 - cullin 2 Gene

Homo sapiens

Gene ID: 8453 | Gene type: protein coding

About CUL2

Cytogenetic location: 10p11.21 Genomic coordinates (GRCh38): 10:35,008,551-35,127,006 (from NCBI)

This gene has 49 transcripts (splice variants), 226 orthologues and 7 paralogues. Ubiquitous expression in testis (RPKM 12.7), brain (RPKM 7.3) and 25 other tissues.

Summary

Enables ubiquitin protein Ligase binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to act upstream of or within protein catabolic process. Located in nucleoplasm. Part of Cul2-RING ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

CUL2 Products(6)

mRNA	Protein	Name
NM_001198777.2	NP_001185706.1	cullin-2 isoform c
NM_001198778.2	NP_001185707.1	cullin-2 isoform a
NM_001198779.1	NP_001185708.1	cullin-2 isoform b
NM_001324375.2	NP_001311304.1	cullin-2 isoform d
NM_001324376.2	NP_001311305.1	cullin-2 isoform e
NM_003591.4	NP_003582.2	cullin-2 isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12504026	GOA
enables ubiquitin ligase complex scaffold activity	IDA IDA: Inferred from direct assay	29779948	GOA
enables ubiquitin protein ligase binding	IDA IDA: Inferred from direct assay	17636018	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	IDA IDA: Inferred from direct assay	29779948	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Cul2-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	17636018	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CUL2 Protein Structure

Cullin

Cullin_Nedd8

0
200
400
600
745 a.a.

Protein Preferred Names

Protein Names

cullin-2

CUL-2

CUL2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CUL2	Q13617	KLHDC3	Homo sapiens	Q9BQ90	TAP	21145461
Intra	CUL2	Q13617	KLHDC3	Homo sapiens	Q9BQ90	Anti Tag CoIP	33961781
Intra	CUL2	Q13617	COMMD1	Homo sapiens	Q8N668	Pull Down	23563313
Intra	CUL2	Q13617	COMMD1	Homo sapiens	Q8N668	Anti Bait CoIP	17183367
Intra	CUL2	Q13617	ZYG11B	Homo sapiens	Q9C0D3	TAP	21145461
Intra	CUL2	Q13617	ZYG11B	Homo sapiens	Q9C0D3	Anti Tag CoIP	33961781
Intra	CUL2	Q13617	UBXN7	Homo sapiens	O94888	TAP	21145461
Intra	CUL2	Q13617	UBXN7	Homo sapiens	O94888	Anti Tag CoIP	22466964
Intra	CUL2	Q13617	LRRC14	Homo sapiens	Q15048	TAP	21145461
Intra	CUL2	Q13617	LRRC14	Homo sapiens	Q15048	Anti Tag CoIP	33961781
Intra	CUL2	Q13617	ELOC	Homo sapiens	Q15369	Anti Tag CoIP	15601820
Intra	CUL2	Q13617	ELOC	Homo sapiens	Q15369	Pull Down	23563313
Intra	CUL2	Q13617	ELOC	Homo sapiens	Q15369	Pull Down	19327355
Intra	CUL2	Q13617	ELOC	Homo sapiens	Q15369	TAP	21145461
Intra	CUL2	Q13617	VHL	Homo sapiens	P40337	GMS	25661653
Intra	CUL2	Q13617	VHL	Homo sapiens	P40337	TAP	21145461
Intra	CUL2	Q13617	VHL	Homo sapiens	P40337	Anti Tag CoIP	33961781
Intra	CUL2	Q13617	VHL	Homo sapiens	P40337	Anti Tag CoIP	18323857
Intra	CUL2	Q13617	VHL	Homo sapiens	P40337	Anti Tag CoIP	15601820
Intra	CUL2	Q13617	VHL	Homo sapiens	P40337	Ion Exchange Chrom	25661653
Intra	CUL2	Q13617	VHL	Homo sapiens	P40337	X-Ray Diffraction	25661653
Intra	CUL2	Q13617	HSP90AB1	Homo sapiens	P08238	TAP	21145461
Intra	CUL2	Q13617	RBX1	Homo sapiens	P62877	Pull Down	19327355
Intra	CUL2	Q13617	RBX1	Homo sapiens	P62877	Anti Tag CoIP	15601820
Intra	CUL2	Q13617	CAND1	Homo sapiens	Q86VP6	Anti Bait CoIP	12504026
Cross	CUL2	Q13617	vif	Human immunodeficiency virus	P12504	Pull Down	22190034

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Moyamoya Angiopathy

External Ear Squamous Cell Carcinoma

Epidermoid Carcinoma Of The External Ear

Squamous Cell Carcinoma Of External Ear

Von Hippel-Lindau Syndrome

Von Hippel-Lindau Disease	Vhl
Vhl Syndrome	VHLS
Von Hippel-Lindau Syndrome, Modifier Of	Hippel Lindau Syndrome
Angiomatosis Retinae	Cerebelloretinal Angiomatosis, Familial
Hippel-Lindau Disease	Familial Cerebelloretinal Angiomatosis
Lindau Disease	VHLD

External Ear Carcinoma

Carcinoma Of External Ear

Carcinoma Of The External Ear

Retinal Hemangioblastoma

Capillary Hemangioma Of Retina

Familial Renal Papillary Carcinoma

Hereditary Papillary Renal Carcinoma

Papillary Renal Cancer Hereditary

Leiomyoma Cutis

Cutaneous Leiomyoma

Leiomyoma Of The Skin

Dermis Tumor

Dermis Tumour	Neoplasm Of Dermis
Tumor Of Dermis	Tumour Of Dermis

Hereditary Renal Cell Carcinoma

Kidney Cancer

Renal Cancer	Renal Carcinoma
Kidney Neoplasm	Malignant Neoplasm Of Kidney Except Pelvis
Malignant Tumour Of Kidney	Kidney Neoplasms
Cancer, Kidney	Cancer, Renal
Malignant Neoplasm Of Kidney	Renal Cell Carcinoma

Pheochromocytoma

Pheochromocytoma, Susceptibility To	Phaeochromocytoma
Adrenal Gland Chromaffin Paraganglioma	Adrenal Gland Chromaffinoma
Adrenal Gland Paraganglioma	Adrenal Gland Pheochromocytoma
Chromaffin Paraganglioma Of The Adrenal Gland	Intraadrenal Paraganglioma
PCC	Chromaffin Cell Tumor
Medullary Chromaffinoma	Medullary Paraganglioma
Pheochromoblastoma	Pheochromocytomas
Chromaffin Cell Neoplasm	Pheochromocytoma, Malignant

Erythrocytosis, Familial, 2

Chuvash Polycythemia	ECYT2
Familial Erythrocytosis 2	Autosomal Recessive Benign Erythrocytosis
Polycythemia, Vhl-Dependent	Chuvash Erythromatosis
Chuvash Type Polycythemia	Chuvash Erythrocytosis
Von Hippel-Lindau-Dependent Polycythemia	Polycythemia Chuvash Type
Vhl-Dependent Polycythemia	Erythrocytosis, Familial, Type 2

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Cardiovascular Organ Benign Neoplasm

Three M Syndrome 1

3-M Syndrome	Yakut Short Stature Syndrome
3m Syndrome	Le Merrer Syndrome
Dolichospondylic Dysplasia	Gloomy Face Syndrome
Three M Syndrome	3M1
3m Syndrome 1	Miller-Mckusick-Malvaux Syndrome
3-Msbn	Three-M Slender-Boned Nanism
Miller-Mckusick-Malvaux-Syndrome	3-M Syndrome 1
3m Syndrome-1	3m Syndrome, Type 1
Dwarfism	Dwarfism Tall Vertebrae

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03360	CUL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CUL2	VGNC	VGNC:71566
Rattus norvegicus	CUL2	RGD	RGD:1310644
Canis familiaris	CUL2	VGNC	VGNC:39729
Mus musculus	CUL2	MGD	MGI:1918995
Bos taurus	CUL2	VGNC	VGNC:27830
Felis catus	CUL2	VGNC	VGNC:61283
Others	CUL2	NCBI

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