2. Gene
  3. CUL2 - cullin 2 Gene

CUL2 - cullin 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 8453 | Gene type: protein coding

About CUL2

Cytogenetic location: 10p11.21 Genomic coordinates (GRCh38): 10:35,008,551-35,127,006 (from NCBI)

This gene has 49 transcripts (splice variants), 226 orthologues and 7 paralogues. Ubiquitous expression in testis (RPKM 12.7), brain (RPKM 7.3) and 25 other tissues.

Summary

Enables ubiquitin protein Ligase binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to act upstream of or within protein catabolic process. Located in nucleoplasm. Part of Cul2-RING ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

CUL2 Products(6)

mRNA Protein Name
NM_001198777.2 NP_001185706.1 cullin-2 isoform c
NM_001198778.2 NP_001185707.1 cullin-2 isoform a
NM_001198779.1 NP_001185708.1 cullin-2 isoform b
NM_001324375.2 NP_001311304.1 cullin-2 isoform d
NM_001324376.2 NP_001311305.1 cullin-2 isoform e
NM_003591.4 NP_003582.2 cullin-2 isoform c
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
12504026 GOA
enables ubiquitin ligase complex scaffold activity IDA
IDA: Inferred from direct assay
29779948 GOA
enables ubiquitin protein ligase binding IDA
IDA: Inferred from direct assay
17636018 GOA
Biological Process GO Annotation Evidence Reference Source
involved in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway IDA
IDA: Inferred from direct assay
29779948 GOA
Cellular Component GO Annotation Evidence Reference Source
part of Cul2-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
17636018 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CUL2 Protein Structure

Cullin

Cullin: Cullin family (14 - 645)

Cullin_Nedd8

Cullin_Nedd8: Cullin protein neddylation domain (672 - 736)

  • 0
  • 200
  • 400
  • 600
  • 745 a.a.
Protein Preferred Names Protein Names

cullin-2

CUL-2

Related Diseases

Diseases Alias
Moyamoya Angiopathy
External Ear Squamous Cell Carcinoma

Epidermoid Carcinoma Of The External Ear

Squamous Cell Carcinoma Of External Ear
Von Hippel-Lindau Syndrome

Von Hippel-Lindau Disease

Vhl

Vhl Syndrome

VHLS

Von Hippel-Lindau Syndrome, Modifier Of

Hippel Lindau Syndrome

Angiomatosis Retinae

Cerebelloretinal Angiomatosis, Familial

Hippel-Lindau Disease

Familial Cerebelloretinal Angiomatosis

Lindau Disease

VHLD
External Ear Carcinoma

Carcinoma Of External Ear

Carcinoma Of The External Ear
Retinal Hemangioblastoma

Capillary Hemangioma Of Retina
Familial Renal Papillary Carcinoma

Hereditary Papillary Renal Carcinoma

Papillary Renal Cancer Hereditary
Leiomyoma Cutis

Cutaneous Leiomyoma

Leiomyoma Of The Skin
Dermis Tumor

Dermis Tumour

Neoplasm Of Dermis

Tumor Of Dermis

Tumour Of Dermis
Hereditary Renal Cell Carcinoma
Kidney Cancer

Renal Cancer

Renal Carcinoma

Kidney Neoplasm

Malignant Neoplasm Of Kidney Except Pelvis

Malignant Tumour Of Kidney

Kidney Neoplasms

Cancer, Kidney

Cancer, Renal

Malignant Neoplasm Of Kidney

Renal Cell Carcinoma
Pheochromocytoma

Pheochromocytoma, Susceptibility To

Phaeochromocytoma

Adrenal Gland Chromaffin Paraganglioma

Adrenal Gland Chromaffinoma

Adrenal Gland Paraganglioma

Adrenal Gland Pheochromocytoma

Chromaffin Paraganglioma Of The Adrenal Gland

Intraadrenal Paraganglioma

PCC

Chromaffin Cell Tumor

Medullary Chromaffinoma

Medullary Paraganglioma

Pheochromoblastoma

Pheochromocytomas

Chromaffin Cell Neoplasm

Pheochromocytoma, Malignant
Erythrocytosis, Familial, 2

Chuvash Polycythemia

ECYT2

Familial Erythrocytosis 2

Autosomal Recessive Benign Erythrocytosis

Polycythemia, Vhl-Dependent

Chuvash Erythromatosis

Chuvash Type Polycythemia

Chuvash Erythrocytosis

Von Hippel-Lindau-Dependent Polycythemia

Polycythemia Chuvash Type

Vhl-Dependent Polycythemia

Erythrocytosis, Familial, Type 2
Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary
Cardiovascular Organ Benign Neoplasm
Three M Syndrome 1

3-M Syndrome

Yakut Short Stature Syndrome

3m Syndrome

Le Merrer Syndrome

Dolichospondylic Dysplasia

Gloomy Face Syndrome

Three M Syndrome

3M1

3m Syndrome 1

Miller-Mckusick-Malvaux Syndrome

3-Msbn

Three-M Slender-Boned Nanism

Miller-Mckusick-Malvaux-Syndrome

3-M Syndrome 1

3m Syndrome-1

3m Syndrome, Type 1

Dwarfism

Dwarfism Tall Vertebrae
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03360 CUL2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CUL2 VGNC VGNC:71566
Rattus norvegicus CUL2 RGD RGD:1310644
Canis familiaris CUL2 VGNC VGNC:39729
Mus musculus CUL2 MGD MGI:1918995
Bos taurus CUL2 VGNC VGNC:27830
Felis catus CUL2 VGNC VGNC:61283
Others CUL2 NCBI