LIN28A - lin-28 homolog A Gene

Homo sapiens

Also known as CSDD1; LIN28; LIN-28; ZCCHC1; lin-28A

Gene ID: 79727 | Gene type: protein coding

About LIN28A

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,410,817-26,429,728 (from NCBI)

This gene has 2 transcripts (splice variants), 303 orthologues and 4 paralogues. Restricted expression toward testis (RPKM 1.6).

Summary

This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of MicroRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with Cancer progression in multiple tissues. [provided by RefSeq, Sep 2015]

LIN28A Products(1)

mRNA	Protein	Name
NM_024674.6	NP_078950.1	protein lin-28 homolog A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	19703396	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	21247876	GOA
enables pre-miRNA binding	IDA IDA: Inferred from direct assay	21247876	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19703396	GOA
enables protein-RNA adaptor activity	IDA IDA: Inferred from direct assay	18951094	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in RNA 3'-end processing	IMP IMP: Inferred from mutant phenotype	19703396	GOA
involved in miRNA catabolic process	IMP IMP: Inferred from mutant phenotype	19703396	GOA
involved in negative regulation of pre-miRNA processing	IDA IDA: Inferred from direct assay	21247876	GOA
involved in positive regulation of cytoplasmic translation	IMP IMP: Inferred from mutant phenotype	21247876	GOA
involved in pre-miRNA processing	IMP IMP: Inferred from mutant phenotype	19703396	GOA
involved in stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	19703396	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in P-body	IDA IDA: Inferred from direct assay	17617744	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	18604195	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	17617744	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17617744	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LIN28A Protein Structure

CSD

zf-CCHC

0
100
209 a.a.

Protein Preferred Names

Protein Names

protein lin-28 homolog A

RNA-binding protein LIN-28

LIN28A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LIN28A	Q9H9Z2	ZNF275	Homo sapiens	Q9NSD4	Validated Y2H	32296183
Intra	LIN28A	Q9H9Z2	ZNF275	Homo sapiens	Q9NSD4	Y2H Array	32296183
Intra	LIN28A	Q9H9Z2	ZNF275	Homo sapiens	Q9NSD4	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

LIN28A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80744	LIN28A Antibody (YA711)	WB	Human, Mouse
HY-P81728	LIN28 Antibody (YA1473)	WB, IHC-P, ICC/IF, IP, FC	Human

Related Diseases

Diseases

Alias

Medulloepithelioma

Diktyoma, Malignant	Medulloepithelioma, Central Nervous System
Medulloepithelioma Of The Central Nervous System

Central Nervous System Primitive Neuroectodermal Neoplasm

Cpnet

Embryonal Tumor With Multilayered Rosettes, C19mc-Altered

Ependymoblastoma

Embryonal Carcinoma

Embryonal Neoplasm	Embryonal Cancer
Primary Extragonadal Embryonal Carcinoma	Embryo Neoplasm
Carcinoma Embryonal	Cancer Embryonal
Carcinoma, Embryonal	Extragonadal Embryonal Carcinoma
Cancer, Embryonal

Germ Cell And Embryonal Cancer

Germ Cell And Embryonal Neoplasm

Perlman Syndrome

Nephroblastomatosis, Fetal Ascites, Macrosomia And Wilms Tumor	PRLMNS
Renal Hamartomas, Nephroblastomatosis, And Fetal Gigantism	Nephroblastomatosis Fetal Ascites Macrosomia And Wilms Tumor
Nephroblastomatosis, Fetal Ascites, Macrosomia, And Wilms Tumor	Nephroblastomatosis - Fetal Ascites - Macrosomia - Wilms Tumor
Renal Hamartomas, Nephroblastomatosis And Fetal Gigantism	Nephroblastomatosis-Fetal Ascites-Macrosomia-Wilms Tumor Syndrome
Renal Hamartomas Nephroblastomatosis And Fetal Gigantism	Nephroblastoma
Fetal Macrosomia

Acrocephalopolysyndactyly Type Iii

Sakati Syndrome	Sakati-Nyhan Syndrome
Acps With Leg Hypoplasia	Acps Iii
Acrocephalopolysyndactyly Type 3	Sakati-Nyhan-Tisdale Syndrome

Inflammatory Bowel Disease 7

IBD7

Germ Cell Cancer

Malignant Germ Cell Tumor	Neoplasms, Germ Cell And Embryonal
Germ Cell Neoplasm	Germ Cell Tumour
Malignant Tumor Of The Germ Cell	Neoplasms Germ Cell
Malignant Germ Cell Neoplasm

Atypical Teratoid Rhabdoid Tumor

Rhabdoid Tumor Predisposition Syndrome	Rtps
Atypical Teratoid/Rhabdoid Tumor	Rhabdoid Predisposition Syndrome
Familial Posterior Fossa Brain Tumor Of Infancy	Familial Rhabdoid Tumor
At/Rt	Atypical Teratoid Rhabdoid Tumour
Atypical Teratoid/Rhabdoid Tumour	Rhabdoid Tumor Of The Cns
Rhabdoid Tumour Of The Cns	Familial Posterior Fossa Brain Tumor Syndrome
Hereditary Swi/Snf Deficiency Syndrome	Atrt

Mature Teratoma

Dermoid Cyst

Benign Teratoma

Supratentorial Cancer

Supratentorial Neoplasms	Brain Neoplasm, Supratentorial
Malignant Supratentorial Tumor	Cancer, Supratentorial

Malignant Teratoma

Immature Teratoma	Malignant Extragonadal Teratoma
Primary Malignant Extragonadal Teratoma	Teratoma, Malignant, Nos
Teratoma, Malignant	Immature Extragonadal Teratoma

Cerebrum Cancer

Cerebral Cancer	Neoplasm Of Cerebrum
Tumor Of Cerebrum	Malignant Neoplasm Of Cerebrum

Retinitis Pigmentosa 50

RP50	Retinitis Pigmentosa, Concentric
Retinitis Pigmentosa-50	Retinitis Pigmentosa Concentric

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100692	Lin28-let-7a antagonist 1	Antagonist	99.48%	Unkown
HY-112659	Lin28-let-7 antagonist 1	Antagonist	99.68%	Unkown
HY-168346	TS-002455		/	Unkown
HY-RS07671	LIN28A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	LIN28A	VGNC	VGNC:42683
Felis catus	LIN28A	VGNC	VGNC:63231
Mus musculus	LIN28A	MGD	MGI:1890546
Rattus norvegicus	LIN28A	RGD	RGD:1566408

Name
Email *

	Sorry, but the email address you supplied was invalid.