LONRF3 - LON peptidase N-terminal domain and ring finger 3 Gene

Homo sapiens

Also known as RNF127

Gene ID: 79836 | Gene type: protein coding

About LONRF3

This gene has 6 transcripts (splice variants), 191 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 3.2), liver (RPKM 3.1) and 25 other tissues.

Summary

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Multiple alternatively spliced transcript variants have been suggested, but their full length natures are not clear. [provided by RefSeq, Jul 2008]

LONRF3 Products(3)

mRNA	Protein	Name
NM_001031855.3	NP_001027026.1	LON peptidase N-terminal domain and RING finger protein 3 isoform 1
NM_001289109.1	NP_001276038.1	LON peptidase N-terminal domain and RING finger protein 3 isoform 3
NM_024778.5	NP_079054.3	LON peptidase N-terminal domain and RING finger protein 3 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20195357	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LONRF3 Protein Structure

zf-C3HC4_2

TPR_11

TPR_2

zf-C3HC4_2

LON_substr_bdg

0
200
400
600
759 a.a.

Protein Preferred Names

Protein Names

LON peptidase N-terminal domain and RING finger protein 3

ring finger protein 127

LONRF3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LONRF3	Q496Y0	DES	Homo sapiens	P17661	Y2H Array	32296183
Intra	LONRF3	Q496Y0	DES	Homo sapiens	P17661	Y2H Prey Pooling	32296183
Intra	LONRF3	Q496Y0	CTAG1A	Homo sapiens	P78358	Y2H Array	32296183
Intra	LONRF3	Q496Y0	CTAG1A	Homo sapiens	P78358	Y2H Prey Pooling	32296183
Intra	LONRF3	Q496Y0	PHB1	Homo sapiens	P35232	TAP	20195357
Intra	LONRF3	Q496Y0	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	LONRF3	Q496Y0	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	LONRF3	Q496Y0	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	LONRF3	Q496Y0	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	LONRF3	Q496Y0	APPBP2	Homo sapiens	Q92624	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cleft Palate With Or Without Ankyloglossia, X-Linked

Cleft Palate With Ankyloglossia	CPX
X-Linked Cleft Palate And Ankyloglossia	X-Linked Cleft Palate With Or Without Ankyloglossia
X-Linked Cleft Palate	X-Linked Cleft Palate With Ankyloglossia
Cleft Palate, With/Without Ankyloglossia, X-Linked

Ankyloglossia With Or Without Tooth Anomalies

Ankyloglossia	ANKG
'Tongue-Tie'	Tongue-Tie
Tongue Tie	Aberrant Insertion Of Labial Frenulum
Aberrant Insertion Of Frenum Of Tongue	Short Frenulum Linguae
Short Frenulum Of Tongue

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07737	LONRF3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LONRF3	VGNC	VGNC:74327
Canis familiaris	LONRF3	VGNC	VGNC:42736
Bos taurus	LONRF3	VGNC	VGNC:30950
Rattus norvegicus	LONRF3	RGD	RGD:1565451
Mus musculus	LONRF3	MGD	MGI:1921615

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