PHB1 - prohibitin 1 Gene

Homo sapiens

Also known as PHB; HEL-215; HEL-S-54e

Gene ID: 5245 | Gene type: protein coding

About PHB1

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:49,404,052-49,414,882 (from NCBI)

This gene has 16 transcripts (splice variants), 245 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in kidney (RPKM 68.3), colon (RPKM 44.2) and 25 other tissues.

Summary

This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

PHB1 Products(4)

mRNA	Protein	Name
NM_001281496.2	NP_001268425.1	prohibitin 1 isoform 1
NM_001281497.2	NP_001268426.1	prohibitin 1 isoform 2
NM_001281715.2	NP_001268644.1	prohibitin 1 isoform 1
NM_002634.4	NP_002625.1	prohibitin 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables complement component C3a binding	IDA IDA: Inferred from direct assay	17070910	GOA
enables complement component C3b binding	IDA IDA: Inferred from direct assay	17070910	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	23921388	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	16964284	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11302691	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	28017329	GOA
enables proteinase activated receptor binding	IPI IPI: Inferred from physical interaction	24732013	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	18487222	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in RIG-I signaling pathway	IDA IDA: Inferred from direct assay	31522117	GOA
involved in T-helper 17 type immune response	IDA IDA: Inferred from direct assay	31899195	GOA
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	31522117	GOA
involved in cellular response to interleukin-6	IDA IDA: Inferred from direct assay	17324931	GOA
involved in epigenetic regulation of gene expression	IDA IDA: Inferred from direct assay	12466959	GOA
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	17008324	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12065415	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	18487222	GOA
involved in negative regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	24732013	GOA
involved in negative regulation of androgen receptor signaling pathway	IDA IDA: Inferred from direct assay	16964284	GOA
involved in negative regulation of androgen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18487222	GOA
involved in negative regulation of cell growth	IMP IMP: Inferred from mutant phenotype	12065415	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18487222	GOA
involved in negative regulation of glucocorticoid receptor signaling pathway	IDA IDA: Inferred from direct assay	16964284	GOA
involved in negative regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	24732013	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16964284	GOA
involved in negative regulation of transcription by competitive promoter binding	IDA IDA: Inferred from direct assay	18487222	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14500729	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	22417827	GOA
involved in positive regulation of G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24732013	GOA
involved in positive regulation of complement activation	IDA IDA: Inferred from direct assay	17070910	GOA
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	26310625	GOA
involved in positive regulation of interleukin-17 production	IMP IMP: Inferred from mutant phenotype	31899195	GOA
acts upstream of positive regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	26310625	GOA
involved in progesterone receptor signaling pathway	IDA IDA: Inferred from direct assay	16964284	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	18339324	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	17008324	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14500729	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	22417827	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16964284	GOA
located in early endosome	IDA IDA: Inferred from direct assay	24732013	GOA
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	17008324	GOA
part of mitochondrial prohibitin complex	IDA IDA: Inferred from direct assay	31522117	GOA
part of mitochondrial prohibitin complex	IPI IPI: Inferred from physical interaction	20959514	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	24732013	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	12466959	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16964284	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15274632	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHB1 Protein Structure

Band_7

0
100
200
272 a.a.

Protein Preferred Names

Protein Names

prohibitin 1

epididymis luminal protein 215

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Chikungunya

Chikungunya Fever	Arbovirus A Chikungunya Type
Chik	Chikv Infection
Ck	Chikungunya Virus Infection
Chikungunya Haemorrhagic Fever	Chikungunya Viral Disease
Chikungunya Mosquito-Borne Viral Fever

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

3-Methylglutaconic Aciduria, Type V

3-Methylglutaconic Aciduria Type 5	Mga5
MGCA5	Dcma
Dcma Syndrome	Dilated Cardiomyopathy With Ataxia
3-Methylglutaconic Aciduria Type V	Mga Type V
Cardiomyopathy, Dilated, With Ataxia	Mga, Type V
Dilated Cardiomyopathy With Ataxia Syndrome	Dnajc19 Defect
3-Methylglutaconic Aciduria 5	3-Alpha-Methylglutaconic Aciduria Type 5
3-@Methylglutaconic Aciduria, Type V

Parkinson Disease 4, Autosomal Dominant

Autosomal Dominant Parkinson Disease 4	PARK4
Parkinson Disease 4, Autosomal Dominant Lewy Body	Parkinson Disease 4
Parkinson'S Disease 4	Autosomal Dominant Lewy Body Parkinson Disease 4
Autosomal Dominant Parkinson'S Disease 4	Parkinson Disease 4 Autosomal Dominant Lewy Body
Parkinson Disease Autosomal Dominant 4	Parkinson Disease Familial Type 4
Parkinson Disease, Type 4

3-Methylglutaconic Aciduria, Type Iii

Optic Atrophy	3-Methylglutaconic Aciduria Type 3
Costeff Syndrome	Mga3
Costeff Optic Atrophy Syndrome	Optic Atrophy Plus Syndrome
Infantile Optic Atrophy With Chorea And Spastic Paraplegia	3-Methylglutaconic Aciduria Type Iii
Autosomal Recessive Optic Atrophy Plus Syndrome	Autosomal Recessive Optic Atrophy Type 3
Opa3 Defect	MGCA3
Mga, Type Iii	Iraqi Jewish Optic Atrophy Plus
Mga Type Iii	Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia
Iraqi-Jewish 'Optic Atrophy Plus'	Optic Atrophy 3, Autosomal Recessive
Opa3, Autosomal Recessive	Opa3-Related 3-Methylglutaconic Aciduria
Iraqi-Jewish Optic Atrophy Plus	Atrophy Of Optic Disc
3-Alpha Methylglutaconic Aciduria Type Iii	Optic Atrophy 3
Optic Atrophy Infantile With Chorea And Spastic Paraplegia	Autosomal Recessive Opa3
Autosomal Recessive Optic Atrophy 3	3-Methylglutaconic Aciduria 3
3-Alpha-Methylglutaconic Aciduria Type 3	Optic Atrophy 3 Autosomal Recessive
Atrophy, Optic	Atrophy, Optic, Plus Syndrome
Optic Nerve Atrophy	Primary Optic Atrophy
Oa - [Optic Atrophy]	Second Cranial Nerve Atrophy
Second Cranium Nerve Atrophy

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114989	Fluorizoline	Inducer	99.77%	Unkown
HY-141475	Acetoacetyl coenzyme A sodium		/	Unkown
HY-162904	BPU17		/	Unkown
HY-RS10407	PHB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PHB1	VGNC	VGNC:55714
Mus musculus	PHB1	MGD	MGI:97572
Macaca mulatta	PHB1	VGNC	VGNC:99194
Rattus norvegicus	PHB1	RGD	RGD:3322
Bos taurus	PHB1	VGNC	VGNC:32808
Others	PHB1	NCBI

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