RABEP2 - rabaptin, RAB GTPase binding effector protein 2 Gene

Homo sapiens

Also known as FRA

Gene ID: 79874 | Gene type: protein coding

About RABEP2

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:28,904,421-28,925,238 (from NCBI)

This gene has 14 transcripts (splice variants), 182 orthologues and 1 paralogue. Ubiquitous expression in prostate (RPKM 13.2), spleen (RPKM 11.9) and 25 other tissues.

Summary

Predicted to enable GTPase activator activity and growth factor activity. Involved in regulation of cilium assembly. Located in cytosol; intracellular membrane-bounded organelle; and microtubule organizing center. [provided by Alliance of Genome Resources, Apr 2022]

RABEP2 Products(1)

mRNA	Protein	Name
NM_024816.3	NP_079092.2	rab GTPase-binding effector protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	27224062	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	27224062	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	27224062	GOA
located in ciliary basal body	IDA IDA: Inferred from direct assay	27224062	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RABEP2 Protein Structure

Rabaptin

Rab5-bind

0
100
200
300
400
500
569 a.a.

Protein Preferred Names

Protein Names

rab GTPase-binding effector protein 2

Rabaptin-5 beta

RABEP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RABEP2	Q9H5N1	SDCCAG8	Homo sapiens	Q86SQ7	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11583	RABEP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RABEP2	VGNC	VGNC:45301
Mus musculus	RABEP2	MGD	MGI:1917564
Bos taurus	RABEP2	VGNC	VGNC:33668
Felis catus	RABEP2	VGNC	VGNC:64474
Rattus norvegicus	RABEP2	RGD	RGD:621416
Macaca mulatta	RABEP2	VGNC	VGNC:76531

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