RPP21 - ribonuclease P/MRP subunit p21 Gene

Homo sapiens

Also known as CAT60; C6orf135

Gene ID: 79897 | Gene type: protein coding

About RPP21

Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38): 6:30,345,156-30,346,857 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele and 162 orthologues. Ubiquitous expression in endometrium (RPKM 10.7), ovary (RPKM 10.6) and 25 other tissues.

Summary

RPP21 is a protein subunit of nuclear ribonuclease P, which processes the 5-prime leader sequence of precursor tRNAs (Jarrous et al., 2001 [PubMed 11497433]).[supplied by OMIM, Jan 2009]

RPP21 Products(3)

mRNA	Protein	Name
NM_001199120.3	NP_001186049.1	ribonuclease P protein subunit p21 isoform 1
NM_001199121.3	NP_001186050.1	ribonuclease P protein subunit p21 isoform 3
NM_024839.4	NP_079115.1	ribonuclease P protein subunit p21 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15096576	GOA
enables ribonuclease P RNA binding	IDA IDA: Inferred from direct assay	16723659	GOA
contributes to ribonuclease P activity	IDA IDA: Inferred from direct assay	30454648	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18291362	GOA
involved in tRNA 5'-leader removal	IDA IDA: Inferred from direct assay	16723659	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of multimeric ribonuclease P complex	IDA IDA: Inferred from direct assay	16723659	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPP21 Protein Structure

Rpr2

0
100
154 a.a.

Protein Preferred Names

Protein Names

ribonuclease P protein subunit p21

RNaseP protein p21

RPP21 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RPP21	Q9H633	RPP40	Homo sapiens	O75818	Anti Tag CoIP	33961781
Intra	RPP21	Q9H633	RPP40	Homo sapiens	O75818	Anti Tag CoIP	30454648

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Anauxetic Dysplasia 2

ANXD2

Anauxetic Dysplasia 1

Anauxetic Dysplasia	Spondylometaepiphyseal Dysplasia, Menger Type
Spondylometaepiphyseal Dysplasia, Anauxetic Type	Spondyloepimetaphyseal Dysplasia, Anauxetic Type
ANXD1	Anxd
Spondylometaepiphyseal Dysplasia Anauxetic Type	Spondylometaepiphyseal Dysplasia Menger Type
Ad	Spondyloepimetaphyseal Dysplasia, Menger Type
Dysplasia, Anauxetic, Type 1

Cartilage-Hair Hypoplasia

Metaphyseal Chondrodysplasia, Mckusick Type	CHH
Mckusick Type Metaphyseal Chondrodysplasia	Metaphyseal Dysplasia Without Hypotrichosis
Cartilage Hair Hypoplasia Like Syndrome	Metaphyseal Chondrodysplasia Mckusick Type
Chhv	Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only
Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency	Cartilage-Hair Syndrome
Mckusick'S Metaphyseal Chondrodysplasia Syndrome	Metaphyseal Chondrodysplasia, Recessive Type
Autosomal Recessive Metaphyseal Chondrodysplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12213	RPP21 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RPP21	VGNC	VGNC:102509
Bos taurus	RPP21	VGNC	VGNC:106902
Canis familiaris	RPP21	VGNC	VGNC:54354
Rattus norvegicus	RPP21	RGD	RGD:1303090
Mus musculus	RPP21	MGD	MGI:1914926

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