2. Gene
  3. NAA60 - N-alpha-acetyltransferase 60, NatF catalytic subunit Gene

NAA60 - N-alpha-acetyltransferase 60, NatF catalytic subunit Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HAT4; NatF; NAT15; hNaa60

Gene ID: 79903 | Gene type: protein coding

About NAA60

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,443,611-3,486,963 (from NCBI)

This gene has 40 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in kidney (RPKM 15.2), duodenum (RPKM 14.4) and 25 other tissues.

Summary

This gene encodes an Enzyme that localizes to the Golgi apparatus, where it transfers an acetyl group to the N-terminus of free proteins. This Enzyme acts on histones, and its activity is important for chromatin assembly and chromosome integrity. Alternative splicing and the use of alternative promoters results in multiple transcript variants. The upstream promoter is located in a differentially methylated region (DMR) and undergoes imprinting; transcript variants originating from this position are expressed from the maternal allele. [provided by RefSeq, Nov 2015]

NAA60 Products(9)

mRNA Protein Name
NM_001083600.3 NP_001077069.1 N-alpha-acetyltransferase 60 isoform a
NM_001083601.3 NP_001077070.1 N-alpha-acetyltransferase 60 isoform a
NM_001317093.1 NP_001304022.1 N-alpha-acetyltransferase 60 isoform b
NM_001317094.2 NP_001304023.1 N-alpha-acetyltransferase 60 isoform c
NM_001317095.2 NP_001304024.1 N-alpha-acetyltransferase 60 isoform d
NM_001317096.2 NP_001304025.1 N-alpha-acetyltransferase 60 isoform e
NM_001317097.2 NP_001304026.1 N-alpha-acetyltransferase 60 isoform f
NM_001317098.2 NP_001304027.1 N-alpha-acetyltransferase 60 isoform f
NM_024845.4 NP_079121.1 N-alpha-acetyltransferase 60 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables histone H4 acetyltransferase activity IDA
IDA: Inferred from direct assay
21981917 GOA
enables peptide alpha-N-acetyltransferase activity IDA
IDA: Inferred from direct assay
21750686 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
27320834 GOA
Biological Process GO Annotation Evidence Reference Source
involved in N-terminal peptidyl-methionine acetylation IDA
IDA: Inferred from direct assay
21750686 GOA
involved in N-terminal protein amino acid acetylation IDA
IDA: Inferred from direct assay
25732826 GOA
involved in cell population proliferation IMP
IMP: Inferred from mutant phenotype
21981917 GOA
involved in nucleosome assembly IDA
IDA: Inferred from direct assay
21981917 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
21981917 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NAA60 Protein Structure

Acetyltransf_1

Acetyltransf_1: Acetyltransferase (GNAT) family (60 - 156)

  • 0
  • 100
  • 200
  • 242 a.a.
Protein Preferred Names Protein Names

N-alpha-acetyltransferase 60

N-acetyltransferase 15 (GCN5-related, putative)

Related Diseases

Diseases Alias
Scheuermann Disease

Scheuermann'S Disease

Spinal Osteochondrosis

Juvenile Osteochondrosis Of Spine

Familial Scheuermann Disease

Familial Scheuermann Juvenile Kyphosis

Familial Spinal Osteochondrosis

Scheuermann Juvenile Kyphosis

Juvenile Osteochondritis Of The Spine

Juvenile Osteochondrosis Of Scheurermann

Scheuermann'S Kyphosis

Sherman'S Disease

Juvenile Kyphosis

Scheuermann Kyphosis

[X]Spinal Osteochondrosis, Unspecified
Microphthalmia, Syndromic 1

MCOPS1

Lenz Microphthalmia Syndrome

Lenz Dysplasia

Mcops4

Syndromic Microphthalmia 1

Lenz Microphthalmia

Maa

Microphthalmia Or Anophthalmos With Associated Anomalies

Syndromic Microphthalmia Type 4

Microphthalmia, Syndromic 4

Microphthalmia, Syndromic 4, Formerly

Mcops4, Formerly

Anop1, Formerly

Maa, Formerly

Lenz Type Microphthalmia

Syndromic Microphthalmia 4

Microphthalmia Lenz Type

Microphthalmia Syndromic 1

Syndromic Microphthalmia Type 1

Microphthalmia Syndromic 4

Microphthalmia With Ankyloblepharon And Intellectual Disability

Microphthalmia, Lenz Type

Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome

Microphthalmia, Syndromic, 1

Anop1

Microphthalmia, Syndromic, Type 1
Temple Syndrome

Uniparental Disomy, Maternal, Chromosome 14

Temple Syndrome Due To Paternal 14q32.2 Microdeletion

Paternal Del(14)(Q32.2)

Temple Syndrome Due To Paternal 14q32.2 Hypomethylation

Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14

Upd(14)Mat
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08992 NAA60 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NAA60 VGNC VGNC:84247
Mus musculus NAA60 MGD MGI:1922013
Canis familiaris NAA60 VGNC VGNC:84246
Macaca mulatta NAA60 VGNC VGNC:96720
Rattus norvegicus NAA60 RGD RGD:1308915
Felis catus NAA60 VGNC VGNC:80603