SIKE1 - suppressor of IKBKE 1 Gene

Homo sapiens

Also known as SIKE

Gene ID: 80143 | Gene type: protein coding

About SIKE1

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:114,769,479-114,780,685 (from NCBI)

This gene has 10 transcripts (splice variants), 201 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 7.5), lymph node (RPKM 7.0) and 25 other tissues.

Summary

SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008]

SIKE1 Products(2)

mRNA	Protein	Name
NM_001102396.2	NP_001095866.1	suppressor of IKBKE 1 isoform 1
NM_025073.3	NP_079349.2	suppressor of IKBKE 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18782753	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	25743393	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	30622739	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	25743393	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of hippo signaling	IDA IDA: Inferred from direct assay	30622739	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of FAR/SIN/STRIPAK complex	IDA IDA: Inferred from direct assay	30622739	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIKE1 Protein Structure

SIKE

0
100
207 a.a.

Protein Preferred Names

Protein Names

suppressor of IKBKE 1

suppressor of IKK epsilon

Related Diseases

Diseases

Alias

Cerebral Cavernous Malformations 3

Cerebral Cavernous Malformation 3	CCM3
Cerebral Cavernous Malformations-3	Cavernous Angiomatous Malformations
Cavernous Hemangioma Of The Brain	Cerebral Capillary Malformations
Cerebral Cavernoma	Familial Cavernous Angioma
Cerebral Cavernous Malformations, Type 3

Cerebral Cavernous Malformations

Cerebral Cavernous Malformation	Cavernous Malformations Of Cns And Retina
Cerebral Cavernous Malformation 1	Cavernous Angiomatous Malformations
Cerebral Capillary Malformations	CCM
Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations	Familial Cavernous Angioma
Cavernous Angioma	Familial Cerebral Cavernous Malformation
Cerebral Cavernous Malformations 1	Cavernous Angioma, Familial
Cam	Cerebral Cavernous Malformations-1
Cavernoma	Central Nervous System Cavernous Hemangioma
Cerebral Cavernous Hemangioma	Familial Cavernous Hemangioma
Familial Cavernous Malformation	Familial Cerebral Cavernous Angioma
Intracerebral Cavernous Hemangioma	CCM1
Cavernous Hemangioma Of The Brain	Cerebral Cavernoma
Cerebral Cavernous Malformations, Type 1	Hemangioma, Cavernous, Central Nervous System
Hemangioma, Cavernous	Angioma, Cavernous

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12920	SIKE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SIKE1	VGNC	VGNC:46172
Mus musculus	SIKE1	MGD	MGI:1913891
Macaca mulatta	SIKE1	VGNC	VGNC:77314
Bos taurus	SIKE1	VGNC	VGNC:34621
Rattus norvegicus	SIKE1	RGD	RGD:1311316
Felis catus	SIKE1	VGNC	VGNC:65145

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