TRAF3IP3 - TRAF3 interacting protein 3 Gene

Homo sapiens

Also known as T3JAM

Gene ID: 80342 | Gene type: protein coding

About TRAF3IP3

Cytogenetic location: 1q32.2 Genomic coordinates (GRCh38): 1:209,756,053-209,782,310 (from NCBI)

This gene has 16 transcripts (splice variants), 189 orthologues and 2 paralogues. Biased expression in lymph node (RPKM 18.7), spleen (RPKM 13.0) and 9 other tissues.

Summary

The gene encodes a protein that mediates cell growth by modulating the c-Jun N-terminal kinase signal transduction pathway. The encoded protein may also interact with a large multi-protein assembly containing the Phosphatase 2A catalytic subunit. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

TRAF3IP3 Products(4)

mRNA	Protein	Name
NM_001287754.2	NP_001274683.1	TRAF3-interacting JNK-activating modulator isoform 2
NM_001320143.2	NP_001307072.1	TRAF3-interacting JNK-activating modulator isoform 1
NM_001320144.2	NP_001307073.1	TRAF3-interacting JNK-activating modulator isoform 4
NM_025228.4	NP_079504.2	TRAF3-interacting JNK-activating modulator isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	31390091	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18782753	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	31390091	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytoplasmic pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	31390091	GOA
involved in positive regulation of type I interferon production	IDA IDA: Inferred from direct assay	31390091	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in mitochondrion	IDA IDA: Inferred from direct assay	31390091	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

TRAF3-interacting JNK-activating modulator

TRAF3 interacting Jun N terminal kinase (JNK) activating modulator

TRAF3IP3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TRAF3IP3	Q9Y228	STRN	Homo sapiens	O43815	Anti Tag CoIP	33961781
Intra	TRAF3IP3	Q9Y228	STRN	Homo sapiens	O43815	Anti Tag CoIP	18782753
Intra	TRAF3IP3	Q9Y228	OSBPL3	Homo sapiens	Q9H4L5	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	OSBPL3	Homo sapiens	Q9H4L5	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	STRN3	Homo sapiens	Q13033	Anti Tag CoIP	33961781
Intra	TRAF3IP3	Q9Y228	STRN3	Homo sapiens	Q13033	Anti Tag CoIP	18782753
Intra	TRAF3IP3	Q9Y228	CCDC138	Homo sapiens	Q96M89-2	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	CCDC138	Homo sapiens	Q96M89-2	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	31515488
Intra	TRAF3IP3	Q9Y228	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	25416956
Intra	TRAF3IP3	Q9Y228	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	25416956
Intra	TRAF3IP3	Q9Y228	LRRC25	Homo sapiens	Q8N386	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	LRRC25	Homo sapiens	Q8N386	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	CEP68	Homo sapiens	Q76N32-2	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	CEP68	Homo sapiens	Q76N32-2	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	MINAR1	Homo sapiens	Q9UPX6	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	MINAR1	Homo sapiens	Q9UPX6	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	GRAMD2A	Homo sapiens	Q8IUY3	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	GRAMD2A	Homo sapiens	Q8IUY3	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	L3MBTL3	Homo sapiens	Q96JM7-2	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	L3MBTL3	Homo sapiens	Q96JM7-2	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	RILPL1	Homo sapiens	Q5EBL4-3	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	RILPL1	Homo sapiens	Q5EBL4-3	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	RIC3	Homo sapiens	Q7Z5B4-5	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	RIC3	Homo sapiens	Q7Z5B4-5	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	EVI2B	Homo sapiens	P34910-2	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	EVI2B	Homo sapiens	P34910-2	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	STRIP1	Homo sapiens	Q5VSL9	Anti Tag CoIP	18782753
Intra	TRAF3IP3	Q9Y228	STRIP1	Homo sapiens	Q5VSL9	Anti Tag CoIP	33961781
Intra	TRAF3IP3	Q9Y228	SIKE1	Homo sapiens	Q9BRV8	Anti Tag CoIP	18782753
Intra	TRAF3IP3	Q9Y228	SIKE1	Homo sapiens	Q9BRV8	Anti Tag CoIP	33961781
Intra	TRAF3IP3	Q9Y228	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	CBARP	Homo sapiens	Q8N350-4	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	CBARP	Homo sapiens	Q8N350-4	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	STMN4	Homo sapiens	Q9H169-2	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	STMN4	Homo sapiens	Q9H169-2	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	LIME1	Homo sapiens	Q9H400	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	LIME1	Homo sapiens	Q9H400	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	TGFBR2	Homo sapiens	P37173	Validated Y2H	32814053
Intra	TRAF3IP3	Q9Y228	TGFBR2	Homo sapiens	P37173	Y2H Array	32814053
Intra	TRAF3IP3	Q9Y228	TGFBR2	Homo sapiens	P37173	Y2H Pooling	32814053
Intra	TRAF3IP3	Q9Y228	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	CCDC88B	Homo sapiens	A6NC98	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	CCDC88B	Homo sapiens	A6NC98	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	GORAB	Homo sapiens	Q5T7V8	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	GORAB	Homo sapiens	Q5T7V8	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	CCNC	Homo sapiens	P24863	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	CCNC	Homo sapiens	P24863	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	PRKACA	Homo sapiens	P17612	Y2H Array	32814053
Intra	TRAF3IP3	Q9Y228	PRKACA	Homo sapiens	P17612	Y2H Pooling	32814053
Intra	TRAF3IP3	Q9Y228	PRKACA	Homo sapiens	P17612	Validated Y2H	32814053
Intra	TRAF3IP3	Q9Y228	EMD	Homo sapiens	P50402	Validated Y2H	32296183
Intra	TRAF3IP3	Q9Y228	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	CDCA7L	Homo sapiens	Q96GN5	Y2H Prey Pooling	25416956
Intra	TRAF3IP3	Q9Y228	CDCA7L	Homo sapiens	Q96GN5	Y2H Array	25416956
Intra	TRAF3IP3	Q9Y228	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	SP100	Homo sapiens	P23497-2	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	SP100	Homo sapiens	P23497-2	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	MOB4	Homo sapiens	Q9Y3A3	Anti Tag CoIP	33961781
Intra	TRAF3IP3	Q9Y228	MOB4	Homo sapiens	Q9Y3A3	Anti Tag CoIP	18782753
Intra	TRAF3IP3	Q9Y228	RACGAP1	Homo sapiens	Q9H0H5	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	RACGAP1	Homo sapiens	Q9H0H5	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	TMEM139	Homo sapiens	Q8IV31	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	TMEM139	Homo sapiens	Q8IV31	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	COQ9	Homo sapiens	O75208	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	COQ9	Homo sapiens	O75208	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	STK24	Homo sapiens	Q9Y6E0	Anti Tag CoIP	18782753
Intra	TRAF3IP3	Q9Y228	ZNRD2	Homo sapiens	O60232	Y2H Prey Pooling	25416956
Intra	TRAF3IP3	Q9Y228	ZNRD2	Homo sapiens	O60232	Y2H Array	25416956
Intra	TRAF3IP3	Q9Y228	FATE1	Homo sapiens	Q969F0	Validated Y2H	25416956
Intra	TRAF3IP3	Q9Y228	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	STX4	Homo sapiens	Q12846	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	STX4	Homo sapiens	Q12846	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	RAD23A	Homo sapiens	P54725	Validated Y2H	32814053
Intra	TRAF3IP3	Q9Y228	RAD23A	Homo sapiens	P54725	Y2H Array	32814053
Intra	TRAF3IP3	Q9Y228	RAD23A	Homo sapiens	P54725	Y2H Pooling	32814053
Intra	TRAF3IP3	Q9Y228	WAC	Homo sapiens	Q9BTA9	Y2H Array	25416956
Intra	TRAF3IP3	Q9Y228	KASH5	Homo sapiens	Q8N6L0	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	SP100	Homo sapiens	P23497	Y2H Array	31515488
Intra	TRAF3IP3	Q9Y228	SP100	Homo sapiens	P23497	Y2H Prey Pooling	25416956
Intra	TRAF3IP3	Q9Y228	CREB3L3	Homo sapiens	Q68CJ9	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	CREB3L3	Homo sapiens	Q68CJ9	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	KIR2DL3	Homo sapiens	P43628	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	KIR2DL3	Homo sapiens	P43628	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	EBAG9	Homo sapiens	O00559	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	EBAG9	Homo sapiens	O00559	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	NDEL1	Homo sapiens	Q9GZM8	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	NDEL1	Homo sapiens	Q9GZM8	Y2H Prey Pooling	25416956
Intra	TRAF3IP3	Q9Y228	NDEL1	Homo sapiens	Q9GZM8	Y2H Prey Pooling	32296183
Intra	TRAF3IP3	Q9Y228	PLEKHO1	Homo sapiens	Q53GL0	Y2H Array	32296183
Intra	TRAF3IP3	Q9Y228	PLEKHO1	Homo sapiens	Q53GL0	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14972	TRAF3IP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TRAF3IP3	VGNC	VGNC:36275
Mus musculus	TRAF3IP3	MGD	MGI:2441706
Rattus norvegicus	TRAF3IP3	RGD	RGD:1304848
Felis catus	TRAF3IP3	VGNC	VGNC:66499
Canis familiaris	TRAF3IP3	VGNC	VGNC:47767
Macaca mulatta	TRAF3IP3	VGNC	VGNC:79877

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