2. Gene
  3. TRAF3IP3 - TRAF3 interacting protein 3 Gene

TRAF3IP3 - TRAF3 interacting protein 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as T3JAM

Gene ID: 80342 | Gene type: protein coding

About TRAF3IP3

Cytogenetic location: 1q32.2 Genomic coordinates (GRCh38): 1:209,756,053-209,782,310 (from NCBI)

This gene has 16 transcripts (splice variants), 189 orthologues and 2 paralogues. Biased expression in lymph node (RPKM 18.7), spleen (RPKM 13.0) and 9 other tissues.

Summary

The gene encodes a protein that mediates cell growth by modulating the c-Jun N-terminal kinase signal transduction pathway. The encoded protein may also interact with a large multi-protein assembly containing the Phosphatase 2A catalytic subunit. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

TRAF3IP3 Products(4)

mRNA Protein Name
NM_001287754.2 NP_001274683.1 TRAF3-interacting JNK-activating modulator isoform 2
NM_001320143.2 NP_001307072.1 TRAF3-interacting JNK-activating modulator isoform 1
NM_001320144.2 NP_001307073.1 TRAF3-interacting JNK-activating modulator isoform 4
NM_025228.4 NP_079504.2 TRAF3-interacting JNK-activating modulator isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
31390091 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18782753 GOA
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
31390091 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cytoplasmic pattern recognition receptor signaling pathway IDA
IDA: Inferred from direct assay
31390091 GOA
involved in positive regulation of type I interferon production IDA
IDA: Inferred from direct assay
31390091 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in mitochondrion IDA
IDA: Inferred from direct assay
31390091 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

TRAF3-interacting JNK-activating modulator

TRAF3 interacting Jun N terminal kinase (JNK) activating modulator

TRAF3IP3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra TRAF3IP3 Q9Y228 STRN Homo sapiens O43815
Anti Tag CoIP
33961781
Intra TRAF3IP3 Q9Y228 STRN Homo sapiens O43815
Anti Tag CoIP
18782753
Intra TRAF3IP3 Q9Y228 OSBPL3 Homo sapiens Q9H4L5
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 OSBPL3 Homo sapiens Q9H4L5
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 STRN3 Homo sapiens Q13033
Anti Tag CoIP
33961781
Intra TRAF3IP3 Q9Y228 STRN3 Homo sapiens Q13033
Anti Tag CoIP
18782753
Intra TRAF3IP3 Q9Y228 CCDC138 Homo sapiens Q96M89-2
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 CCDC138 Homo sapiens Q96M89-2
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 TFIP11 Homo sapiens Q9UBB9
Y2H Array
31515488
Intra TRAF3IP3 Q9Y228 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
25416956
Intra TRAF3IP3 Q9Y228 TFIP11 Homo sapiens Q9UBB9
Y2H Array
25416956
Intra TRAF3IP3 Q9Y228 LRRC25 Homo sapiens Q8N386
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 LRRC25 Homo sapiens Q8N386
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 CEP68 Homo sapiens Q76N32-2
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 CEP68 Homo sapiens Q76N32-2
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 MINAR1 Homo sapiens Q9UPX6
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 MINAR1 Homo sapiens Q9UPX6
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 GRAMD2A Homo sapiens Q8IUY3
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 GRAMD2A Homo sapiens Q8IUY3
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 L3MBTL3 Homo sapiens Q96JM7-2
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 L3MBTL3 Homo sapiens Q96JM7-2
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 RILPL1 Homo sapiens Q5EBL4-3
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 RILPL1 Homo sapiens Q5EBL4-3
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 RIC3 Homo sapiens Q7Z5B4-5
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 RIC3 Homo sapiens Q7Z5B4-5
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 EVI2B Homo sapiens P34910-2
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 EVI2B Homo sapiens P34910-2
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 STRIP1 Homo sapiens Q5VSL9
Anti Tag CoIP
18782753
Intra TRAF3IP3 Q9Y228 STRIP1 Homo sapiens Q5VSL9
Anti Tag CoIP
33961781
Intra TRAF3IP3 Q9Y228 SIKE1 Homo sapiens Q9BRV8
Anti Tag CoIP
18782753
Intra TRAF3IP3 Q9Y228 SIKE1 Homo sapiens Q9BRV8
Anti Tag CoIP
33961781
Intra TRAF3IP3 Q9Y228 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 CBARP Homo sapiens Q8N350-4
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 CBARP Homo sapiens Q8N350-4
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 STMN4 Homo sapiens Q9H169-2
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 STMN4 Homo sapiens Q9H169-2
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 LIME1 Homo sapiens Q9H400
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 LIME1 Homo sapiens Q9H400
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 TGFBR2 Homo sapiens P37173
Validated Y2H
32814053
Intra TRAF3IP3 Q9Y228 TGFBR2 Homo sapiens P37173
Y2H Array
32814053
Intra TRAF3IP3 Q9Y228 TGFBR2 Homo sapiens P37173
Y2H Pooling
32814053
Intra TRAF3IP3 Q9Y228 KRT27 Homo sapiens Q7Z3Y8
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 KRT27 Homo sapiens Q7Z3Y8
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 CCDC88B Homo sapiens A6NC98
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 CCDC88B Homo sapiens A6NC98
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 GORAB Homo sapiens Q5T7V8
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 GORAB Homo sapiens Q5T7V8
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 CCNC Homo sapiens P24863
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 CCNC Homo sapiens P24863
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 PRKACA Homo sapiens P17612
Y2H Array
32814053
Intra TRAF3IP3 Q9Y228 PRKACA Homo sapiens P17612
Y2H Pooling
32814053
Intra TRAF3IP3 Q9Y228 PRKACA Homo sapiens P17612
Validated Y2H
32814053
Intra TRAF3IP3 Q9Y228 EMD Homo sapiens P50402
Validated Y2H
32296183
Intra TRAF3IP3 Q9Y228 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 CDCA7L Homo sapiens Q96GN5
Y2H Prey Pooling
25416956
Intra TRAF3IP3 Q9Y228 CDCA7L Homo sapiens Q96GN5
Y2H Array
25416956
Intra TRAF3IP3 Q9Y228 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 SP100 Homo sapiens P23497-2
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 SP100 Homo sapiens P23497-2
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 MOB4 Homo sapiens Q9Y3A3
Anti Tag CoIP
33961781
Intra TRAF3IP3 Q9Y228 MOB4 Homo sapiens Q9Y3A3
Anti Tag CoIP
18782753
Intra TRAF3IP3 Q9Y228 RACGAP1 Homo sapiens Q9H0H5
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 RACGAP1 Homo sapiens Q9H0H5
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 TMEM139 Homo sapiens Q8IV31
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 TMEM139 Homo sapiens Q8IV31
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 COQ9 Homo sapiens O75208
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 COQ9 Homo sapiens O75208
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 STK24 Homo sapiens Q9Y6E0
Anti Tag CoIP
18782753
Intra TRAF3IP3 Q9Y228 ZNRD2 Homo sapiens O60232
Y2H Prey Pooling
25416956
Intra TRAF3IP3 Q9Y228 ZNRD2 Homo sapiens O60232
Y2H Array
25416956
Intra TRAF3IP3 Q9Y228 FATE1 Homo sapiens Q969F0
Validated Y2H
25416956
Intra TRAF3IP3 Q9Y228 FATE1 Homo sapiens Q969F0
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 STX4 Homo sapiens Q12846
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 STX4 Homo sapiens Q12846
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 RAD23A Homo sapiens P54725
Validated Y2H
32814053
Intra TRAF3IP3 Q9Y228 RAD23A Homo sapiens P54725
Y2H Array
32814053
Intra TRAF3IP3 Q9Y228 RAD23A Homo sapiens P54725
Y2H Pooling
32814053
Intra TRAF3IP3 Q9Y228 WAC Homo sapiens Q9BTA9
Y2H Array
25416956
Intra TRAF3IP3 Q9Y228 KASH5 Homo sapiens Q8N6L0
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 SP100 Homo sapiens P23497
Y2H Array
31515488
Intra TRAF3IP3 Q9Y228 SP100 Homo sapiens P23497
Y2H Prey Pooling
25416956
Intra TRAF3IP3 Q9Y228 CREB3L3 Homo sapiens Q68CJ9
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 CREB3L3 Homo sapiens Q68CJ9
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 KIR2DL3 Homo sapiens P43628
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 KIR2DL3 Homo sapiens P43628
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 EBAG9 Homo sapiens O00559
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 EBAG9 Homo sapiens O00559
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 NDEL1 Homo sapiens Q9GZM8
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 NDEL1 Homo sapiens Q9GZM8
Y2H Prey Pooling
25416956
Intra TRAF3IP3 Q9Y228 NDEL1 Homo sapiens Q9GZM8
Y2H Prey Pooling
32296183
Intra TRAF3IP3 Q9Y228 PLEKHO1 Homo sapiens Q53GL0
Y2H Array
32296183
Intra TRAF3IP3 Q9Y228 PLEKHO1 Homo sapiens Q53GL0
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14972 TRAF3IP3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TRAF3IP3 VGNC VGNC:36275
Mus musculus TRAF3IP3 MGD MGI:2441706
Rattus norvegicus TRAF3IP3 RGD RGD:1304848
Felis catus TRAF3IP3 VGNC VGNC:66499
Canis familiaris TRAF3IP3 VGNC VGNC:47767
Macaca mulatta TRAF3IP3 VGNC VGNC:79877