WDR26 - WD repeat domain 26 Gene

Homo sapiens

Also known as CDW2; GID7; MIP2; SKDEAS

Gene ID: 80232 | Gene type: protein coding

About WDR26

Cytogenetic location: 1q42.11-q42.12 Genomic coordinates (GRCh38): 1:224,385,146-224,434,797 (from NCBI)

This gene has 16 transcripts (splice variants), 275 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in bone marrow (RPKM 30.1), esophagus (RPKM 28.6) and 25 other tissues.

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

WDR26 Products(3)

mRNA	Protein	Name
NM_001115113.3	NP_001108585.2	WD repeat-containing protein 26 isoform b
NM_001379403.1	NP_001366332.1	WD repeat-containing protein 26 isoform c
NM_025160.7	NP_079436.4	WD repeat-containing protein 26 isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17510365	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15378603	GOA
located in nucleus	IDA IDA: Inferred from direct assay	29911972	GOA
part of ubiquitin ligase complex	IDA IDA: Inferred from direct assay	29911972	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR26 Protein Structure

WD40

0
200
400
600
661 a.a.

Protein Preferred Names

Protein Names

WD repeat-containing protein 26

CUL4- and DDB1-associated WDR protein 2

WDR26 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	WDR26	Q9H7D7	AXIN1	Homo sapiens	O15169	Anti Bait CoIP	27098453
Intra	WDR26	Q9H7D7	AXIN1	Homo sapiens	O15169	Anti Tag CoIP	27098453

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Skraban-Deardorff Syndrome

SKDEAS	Intellectual Disability With Seizures, Abnormal Gait, And Distinctive Facial Features
Intellectual Disability-Seizures-Abnormal Gait-Facial Dysmorphism Syndrome	Intellectual Disability, Seizures, Abnormal Gait And Distinctive Facial Features

Chromosome 1q41-Q42 Deletion Syndrome

1q41-Q42 Microdeletion Syndrome	1q41q42 Microdeletion Syndrome
Holoprosencephaly 10, Included	Hpe10, Included
1q41-Q42 Deletion Syndrome	Deletion 1q41-Q42
Monosomy 1q41-Q42	Del(1)(Q41q42)
Monosomy 1q41q42	Chromosome Deletion Syndrome 1q41-Q42
Holoprosencephaly 10

Kbg Syndrome

KBGS	Macrodontia, Mental Retardation, Characteristic Facies, Short Stature, And Skeletal Anomalies
Short Stature, Characteristic Facies, Macrodontia, Intellectual Disability, And Skeletal Anomalies	Short Stature, Characteristic Facies, Macrodontia, Mental Retardation, And Skeletal Anomalies
Short Stature-Characteristic Facies-Mental Retardation-Macrodontia-Skeletal Anomalies Syndrome	Short Stature-Facial And Skeletal Anomalies-Intellectual Disability-Macrodontia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15770	WDR26 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	WDR26	VGNC	VGNC:48358
Macaca mulatta	WDR26	VGNC	VGNC:79315
Bos taurus	WDR26	VGNC	VGNC:36889
Rattus norvegicus	WDR26	RGD	RGD:1565589
Felis catus	WDR26	VGNC	VGNC:67023
Mus musculus	WDR26	MGD	MGI:1923825

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