2. Gene
  3. GRPEL1 - GrpE like 1, mitochondrial Gene

GRPEL1 - GrpE like 1, mitochondrial Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GrpE; HMGE; mt-GrpE#1

Gene ID: 80273 | Gene type: protein coding

About GRPEL1

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:7,058,895-7,068,064 (from NCBI)

This gene has 4 transcripts (splice variants), 221 orthologues and 1 paralogue. Ubiquitous expression in adrenal (RPKM 26.2), kidney (RPKM 13.9) and 25 other tissues.

Summary

Enables identical protein binding activity and unfolded protein binding activity. Predicted to be involved in protein import into mitochondrial matrix. Located in mitochondrial matrix and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

GRPEL1 Products(1)

mRNA Protein Name
NM_025196.4 NP_079472.1 grpE protein homolog 1, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
enables unfolded protein binding IDA
IDA: Inferred from direct assay
11311562 GOA
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
11311562 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRPEL1 Protein Structure

GrpE

GrpE: GrpE (47 - 215)

  • 0
  • 100
  • 200
  • 217 a.a.
Protein Preferred Names Protein Names

grpE protein homolog 1, mitochondrial

GrpE-like protein cochaperone

Related Diseases

Diseases Alias
Human Monocytic Ehrlichiosis

Ehrlichiosis Chafeensis

Hme

Human Ehrlichial Infection, Human Monocytic Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05845 GRPEL1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GRPEL1 MGD MGI:1334417
Macaca mulatta GRPEL1 VGNC VGNC:106588
Rattus norvegicus GRPEL1 RGD RGD:70947
Felis catus GRPEL1 VGNC VGNC:107337
Bos taurus GRPEL1 VGNC VGNC:29665
Canis familiaris GRPEL1 VGNC VGNC:41517