2. Gene
  3. CD276 - CD276 molecule Gene

CD276 - CD276 molecule Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as B7H3; B7-H3; B7RP-2; 4Ig-B7-H3

Gene ID: 80381 | Gene type: protein coding

About CD276

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:73,683,944-73,714,514 (from NCBI)

This gene has 19 transcripts (splice variants), 203 orthologues and 15 paralogues. Ubiquitous expression in placenta (RPKM 22.3), gall bladder (RPKM 17.0) and 24 other tissues.

Summary

The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 MicroRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

CD276 Products(4)

mRNA Protein Name
NM_001024736.2 NP_001019907.1 CD276 antigen isoform a precursor
NM_001329628.2 NP_001316557.1 CD276 antigen isoform b precursor
NM_001329629.2 NP_001316558.1 CD276 antigen isoform c
NM_025240.3 NP_079516.1 CD276 antigen isoform b precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
18650384 GOA
Biological Process GO Annotation Evidence Reference Source
involved in T cell activation IDA
IDA: Inferred from direct assay
18650384 GOA
involved in positive regulation of T cell proliferation IDA
IDA: Inferred from direct assay
11224528 GOA
involved in positive regulation of type II interferon production IDA
IDA: Inferred from direct assay
11224528 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD276 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (30 - 127)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (148 - 228)

V-set

V-set: Immunoglobulin V-set domain (247 - 345)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (366 - 446)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 534 a.a.
Protein Preferred Names Protein Names

CD276 antigen

B7 homolog 3

Recombinant CD276 Proteins

Cat. No. Product Name Accession Purity
HY-P7326 CD276/B7-H3 Protein, Human (435a.a, HEK293, Fc) Q5ZPR3-1 (L29-P463) ≥95%
HY-P7327 CD276/B7-H3 Protein, Human (HEK293, His) Q5ZPR3-2 (L29-P245) ≥95%
HY-P70652 CD276/B7-H3 Protein, Human (433a.a, HEK293, His) Q5ZPR3-1 (L29-T461) ≥95%
HY-P77538 CD276/B7-H3 Protein, Human (Biotinylated, HEK293, His) Q5ZPR3-1 (L29-T461) ≥95%
HY-P77578 CD276/B7-H3 Protein, Human (217a.a, HEK293, Fc) Q5ZPR3-2 (L29-P245) ≥95%
HY-P78074 CD276/B7-H3 Protein, Human (Biotinylated, HEK293, His-Avi) Q5ZPR3-1 (G27-T461) ≥95%
HY-P78391 CD276/B7-H3 Protein, Human (HEK293, His-Avi) Q5ZPR3-1 (G27-T461) ≥95%
HY-P78930 CD276/B7-H3 Protein, Human (Biotinylated, HEK293, Fc-Avi) Q5ZPR3-2 (L29-P245) ≥95%
HY-P700448 CD276/B7-H3 Protein, Human (HEK293, Myc-hFc) Q5ZPR3-1 (L29-G245) ≥95%
HY-P700880 CD276/B7-H3 Protein, Human (Biotinylated, HEK293, C-His-Avi) Q5ZPR3-2 (L29-P245) ≥95%

Related Diseases

Diseases Alias
Immunodeficiency 16

Combined Immunodeficiency Due To Ox40 Deficiency

IMD16

Ox40 Deficiency

Combined Immunodeficiency With Childhood-Onset Kaposi Sarcoma

Combined Immunodeficiency With Impaired Immunity To Hhv-8

Combined Immunodeficiency With Impaired Immunity To Human Herpes Virus 8

Immunodeficiency, Type 16
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma
Craniopharyngioma

Neoplasm Of Rathke'S Pouch

Adamantinomatous Tumor

Craniopharyngeal Duct Tumor

Dysodontogenic Epithelial Tumor

Rathke'S Pouch Tumor
Autoimmune Peripheral Neuropathy
Central Nervous System Neuroblastoma
Rhabdomyosarcoma
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site
Co-Trimoxazole Allergy

Bactrim Allergy

Cotrimoxazol Allergy

Tmp/Smx Allergy

Trimethoprim/Sulfamethoxazole Allergy
Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary
Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99157 Omburtamab Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02220 CD276 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99740 Mirzotamab Inhibitor 95.00% Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CD276 RGD RGD:727815
Canis familiaris CD276 VGNC VGNC:38943
Felis catus CD276 VGNC VGNC:60603
Bos taurus CD276 VGNC VGNC:27020
Mus musculus CD276 MGD MGI:2183926
Macaca mulatta CD276 VGNC VGNC:70826
Macaca fascicularis CD276 NCBI NCBI:102131295
Others CD276 NCBI