AKNA - AT-hook transcription factor Gene

Homo sapiens

Gene ID: 80709 | Gene type: protein coding

About AKNA

Cytogenetic location: 9q32 Genomic coordinates (GRCh38): 9:114,330,504-114,398,472 (from NCBI)

This gene has 9 transcripts (splice variants), 156 orthologues and 1 paralogue. Broad expression in spleen (RPKM 28.7), lymph node (RPKM 23.1) and 20 other tissues.

Summary

Predicted to enable DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in centrosome; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

AKNA Products(3)

mRNA	Protein	Name
NM_001317950.2	NP_001304879.1	microtubule organization protein AKNA isoform 1
NM_001317952.1	NP_001304881.1	microtubule organization protein AKNA isoform 2
NM_030767.5	NP_110394.3	microtubule organization protein AKNA isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16000308	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11268217	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKNA Protein Structure

AKNA

0
300
600
900
1200
1439 a.a.

Protein Preferred Names

Protein Names

microtubule organization protein AKNA

AKNA transcript F2

Related Diseases

Diseases

Alias

Vogt-Koyanagi-Harada Disease

Uveomeningoencephalitic Syndrome	Uveomenigitic Syndrome
Vogt-Koyanagi-Harada Syndrome	Harada'S Disease
Vogt-Koyanagi Syndrome	Vkh Disease
Vkh Syndrome	Vkh

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00529	AKNA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AKNA	RGD	RGD:1308202
Mus musculus	AKNA	MGD	MGI:2140340
Bos taurus	AKNA	VGNC	VGNC:55031
Macaca mulatta	AKNA	VGNC	VGNC:69684
Canis familiaris	AKNA	VGNC	VGNC:37767
Felis catus	AKNA	VGNC	VGNC:59722

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