CD2BP2 - CD2 cytoplasmic tail binding protein 2 Gene

Homo sapiens

Also known as LIN1; Snu40; FWP010; U5-52K; PPP1R59

Gene ID: 10421 | Gene type: protein coding

About CD2BP2

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:30,350,773-30,355,308 (from NCBI)

This gene has 3 transcripts (splice variants) and 186 orthologues. Ubiquitous expression in brain (RPKM 16.4), lymph node (RPKM 14.8) and 25 other tissues.

Summary

This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. [provided by RefSeq, Nov 2008]

CD2BP2 Products(2)

mRNA	Protein	Name
NM_001243646.2	NP_001230575.1	CD2 antigen cytoplasmic tail-binding protein 2
NM_006110.3	NP_006101.1	CD2 antigen cytoplasmic tail-binding protein 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9843987	GOA
enables ribonucleoprotein complex binding	IDA IDA: Inferred from direct assay	15840814	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
NOT part of U4/U6 x U5 tri-snRNP complex	IDA IDA: Inferred from direct assay	15840814	GOA
part of U5 snRNP	IDA IDA: Inferred from direct assay	15840814	GOA
colocalizes with nuclear speck	IDA IDA: Inferred from direct assay	15840814	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	15840814	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15840814	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD2BP2 Protein Structure

GYF

0
100
200
300
341 a.a.

Protein Preferred Names

Protein Names

CD2 antigen cytoplasmic tail-binding protein 2

CD2 cytoplasmic domain-binding protein 2

Related Diseases

Diseases

Alias

Lobular Neoplasia

Lobular Carcinoma In Situ	Lobular Carcinoma In Situ Of Breast
Lobular Intraepithelial Neoplasia	Non-Infiltrating Lobular Carcinoma
Noninfiltrating Lobular Carcinoma Unspecified Site	Noninfiltrating Lobular Carcinoma Of Breast
Lobular Carcinoma In Situ Unspecified Site

Tolosa-Hunt Syndrome

Painful Ophthalmoplegia	Tolosa Hunt Syndrome
Nonspecific Inflammation Of The Cavernous Sinus Or Superior Orbital Fissure	Ths
Ophthalmoplegia, Painful

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02225	CD2BP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CD2BP2	VGNC	VGNC:27023
Canis familiaris	CD2BP2	VGNC	VGNC:38946
Rattus norvegicus	CD2BP2	RGD	RGD:1311741
Felis catus	CD2BP2	VGNC	VGNC:60606
Macaca mulatta	CD2BP2	VGNC	VGNC:97746
Mus musculus	CD2BP2	MGD	MGI:1917483

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