SRCIN1 - SRC kinase signaling inhibitor 1 Gene

Homo sapiens

Also known as P140; SNIP

Gene ID: 80725 | Gene type: protein coding

About SRCIN1

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:38,530,031-38,607,025 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 282 orthologues and 1 paralogue. Biased expression in brain (RPKM 9.1), salivary gland (RPKM 1.2) and 2 other tissues.

Summary

Enables protein kinase binding activity. Involved in several processes, including regulation of dendritic spine morphogenesis; regulation of protein tyrosine kinase activity; and substrate adhesion-dependent cell spreading. Located in actin Cytoskeleton and cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SRCIN1 Products(1)

mRNA	Protein	Name
NM_025248.3	NP_079524.2	SRC kinase signaling inhibitor 1

Protein Preferred Names

Protein Names

SRC kinase signaling inhibitor 1

P130Cas-associated protein

Related Diseases

Diseases

Alias

Maxillary Sinus Inverted Papilloma

Inverted Papilloma Of The Maxillary Sinus

Maxillary Sinus Benign Neoplasm

Neoplasm Of Maxillary Sinus	Tumor Of Maxillofacial Sinus
Maxillary Sinus Neoplasms	Maxillary Sinus Neoplasm

Frontal Sinus Inverted Papilloma

Inverted Papilloma Of The Frontal Sinus

Larynx Squamous Papilloma

Laryngeal Squamous Cell Papilloma

Frontal Sinus Benign Neoplasm

Neoplasm Of Frontal Sinus

Tumor Of The Frontal Sinus

Inverted Papilloma

Inverted Papilloma, Squamous Cell	Papilloma Inverted
Papilloma, Inverted	Inverted Squamous Cell Papilloma

Bipolar I Disorder

Manic Depression Nos	Manic-Depressive Illness
Bipolar Disorder Nos

Paranoid Personality Disorder

Schizoaffective Disorder

Schizo-Affective Psychosis	Schizo-Affective Type Schizophrenia
Schizoaffective Psychosis	Schizoaffective Schizophrenia
Schizophrenia, Schizo-Affective Type	Schizophreniform Psychosis, Affective Type

Kohlschutter-Tonz Syndrome

Amelocerebrohypohidrotic Syndrome	KTZS
Epilepsy And Yellow Teeth	Kohlschutter Tonz Syndrome
Kohlschutter Syndrome	Epilepsy Dementia Amelogenesis Imperfecta
Epilepsy-Dementia-Amelogenesis Imperfecta Syndrome	Epilepsy, Dementia, And Amelogenesis Imperfecta
Kohlschutter'S Syndrome	Kohlschütter-Tönz Syndrome
Kohlschuetter-Toenz Syndrome	Presenile Dementia
Dementia

Myopathy, Centronuclear, 2

Myopathy, Centronuclear, Autosomal Recessive	Autosomal Recessive Centronuclear Myopathy
CNM2	Centronuclear Myopathy 2
Ar-Cnm	Myotubular Myopathy, Autosomal Recessive
Autosomal Recessive Myotubular Myopathy	Centronuclear Myopathy Autosomal Recessive
Myopathy, Centronuclear, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16905	T338C Src-IN-1	Inhibitor	/	Unkown
HY-RS13753	SRCIN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SRCIN1	VGNC	VGNC:78012
Mus musculus	SRCIN1	MGD	MGI:1933179
Canis familiaris	SRCIN1	VGNC	VGNC:46792
Bos taurus	SRCIN1	VGNC	VGNC:35270
Felis catus	SRCIN1	VGNC	VGNC:65672
Rattus norvegicus	SRCIN1	RGD	RGD:708439

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