BCAR1 - BCAR1 scaffold protein, Cas family member Gene

Homo sapiens

Also known as CAS; CAS1; CASS1; CRKAS; P130Cas

Gene ID: 9564 | Gene type: protein coding

About BCAR1

Cytogenetic location: 16q23.1 Genomic coordinates (GRCh38): 16:75,228,181-75,268,007 (from NCBI)

This gene has 22 transcripts (splice variants), 1 gene allele, 201 orthologues and 3 paralogues. Broad expression in spleen (RPKM 6.5), kidney (RPKM 6.3) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, Apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and Cancer. [provided by RefSeq, Sep 2017]

BCAR1 Products(9)

mRNA	Protein	Name
NM_001170714.3	NP_001164185.1	breast cancer anti-estrogen resistance protein 1 isoform 1
NM_001170715.3	NP_001164186.1	breast cancer anti-estrogen resistance protein 1 isoform 2
NM_001170716.3	NP_001164187.1	breast cancer anti-estrogen resistance protein 1 isoform 3
NM_001170717.3	NP_001164188.1	breast cancer anti-estrogen resistance protein 1 isoform 4
NM_001170718.3	NP_001164189.1	breast cancer anti-estrogen resistance protein 1 isoform 5
NM_001170719.3	NP_001164190.1	breast cancer anti-estrogen resistance protein 1 isoform 7
NM_001170720.3	NP_001164191.1	breast cancer anti-estrogen resistance protein 1 isoform 8
NM_001170721.3	NP_001164192.1	breast cancer anti-estrogen resistance protein 1 isoform 9
NM_014567.5	NP_055382.2	breast cancer anti-estrogen resistance protein 1 isoform 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9285683	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	8070403	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in B cell receptor signaling pathway	IDA IDA: Inferred from direct assay	9020138	GOA
involved in actin filament organization	IDA IDA: Inferred from direct assay	16105984	GOA
involved in antigen receptor-mediated signaling pathway	IDA IDA: Inferred from direct assay	10587647	GOA
involved in cell chemotaxis	IMP IMP: Inferred from mutant phenotype	21245381	GOA
involved in cell migration	IDA IDA: Inferred from direct assay	9425168	GOA
involved in cellular response to hepatocyte growth factor stimulus	IMP IMP: Inferred from mutant phenotype	21245381	GOA
involved in endothelin receptor signaling pathway	IDA IDA: Inferred from direct assay	19086031	GOA
involved in hepatocyte growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21245381	GOA
involved in integrin-mediated signaling pathway	IDA IDA: Inferred from direct assay	8649368	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	9472046	GOA
involved in positive regulation of endothelial cell migration	IDA IDA: Inferred from direct assay	21245381	GOA
involved in vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21245381	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8070403	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	21245381	GOA
colocalizes with plasma membrane	IDA IDA: Inferred from direct assay	21245381	GOA
located in ruffle	IDA IDA: Inferred from direct assay	9472046	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BCAR1 Protein Structure

SH3_1

Serine_rich

DUF3513

0
200
400
600
800
870 a.a.

Protein Preferred Names

Protein Names

breast cancer anti-estrogen resistance protein 1

BCAR1, Cas family scaffold protein

BCAR1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BCAR1	P56945	ANKS1A	Homo sapiens	Q49AR9	Validated Y2H	32296183
Intra	BCAR1	P56945	EEIG1	Homo sapiens	Q5T9C2-3	Validated Y2H	32296183
Intra	BCAR1	P56945	TNS3	Homo sapiens	Q68CZ2	Pull Down	19732724
Intra	BCAR1	P56945	TNS3	Homo sapiens	Q68CZ2	IF	19732724
Intra	BCAR1	P56945	INPPL1	Homo sapiens	O15357	Anti Bait CoIP	11158326
Intra	BCAR1	P56945	SRCIN1	Homo sapiens	Q9C0H9	Anti Bait CoIP	14657239
Intra	BCAR1	P56945	BCAR3	Homo sapiens	O75815-1	ITC	22081014
Intra	BCAR1	P56945	BCAR3	Homo sapiens	O75815-1	GMS	22081014
Intra	BCAR1	P56945	BCAR3	Homo sapiens	O75815-1	Anti Bait CoIP	22081014
Intra	BCAR1	P56945	PTPN12	Homo sapiens	Q05209	Affinity Chrom	9285683
Intra	BCAR1	P56945	PRAM1	Homo sapiens	Q96QH2	Validated Y2H	32296183
Intra	BCAR1	P56945	IQGAP1	Homo sapiens	P46940	Anti Bait CoIP	28007913
Intra	BCAR1	P56945	FYN	Homo sapiens	P06241	Pull Down	9360983
Intra	BCAR1	P56945	TNK2	Homo sapiens	Q07912	Pull Down	17038317
Intra	BCAR1	P56945	TNK2	Homo sapiens	Q07912	Anti Bait CoIP	17038317
Intra	BCAR1	P56945	SRC	Homo sapiens	P12931	Pull Down	17038317
Intra	BCAR1	P56945	SRC	Homo sapiens	P12931	CoIP	21034468
Intra	BCAR1	P56945	SRC	Homo sapiens	P12931	Fluorescence	10542110
Intra	BCAR1	P56945	FAM90A1	Homo sapiens	Q86YD7	Validated Y2H	32296183
Intra	BCAR1	P56945	GLIS2	Homo sapiens	Q9BZE0	Validated Y2H	32296183
Intra	BCAR1	P56945	SH2D3C	Homo sapiens	Q8N5H7	Anti Tag CoIP	33961781
Cross	BCAR1	P56945	Srcin1	Mus musculus	Q9QWI6	Anti Bait CoIP	14657239
Intra	BCAR1	P56945	CRK	Homo sapiens	P46108	Anti Bait CoIP	14657239
Intra	BCAR1	P56945	CRK	Homo sapiens	P46108	Pull Down	17038317
Intra	BCAR1	P56945	PTPN1	Homo sapiens	P18031	Anti Bait CoIP	9407132
Intra	BCAR1	P56945	PTPN1	Homo sapiens	P18031	Filter Binding	9418872
Intra	BCAR1	P56945	PTPN1	Homo sapiens	P18031	Phosphatase Assay	10889023
Intra	BCAR1	P56945	MMP14	Homo sapiens	P50281	Anti Bait CoIP	18164686

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Estrogen Resistance

Estrogen Resistance Syndrome	ESTRR
Estrogen Insensitivity

Cystic Kidney Disease

Renal Cyst	Simple Renal Cyst
Kidney Cysts	Kidney Diseases, Cystic
Renal Cysts	Kidney Cyst
Cystic Kidney	Congenital Cystic Kidney Disease
Cystic Kidney Diseases	Bosniak 1 Cyst

Nephronophthisis 1

NPHP1	Nephronophthisis, Familial Juvenile
Nph1	Nephronophthisis 1, Juvenile
Juvenile Nephronophthisis 1	Familial Juvenile Nephronophthisis 1
Nephronophthisis, Type 1

Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome	Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer
Breast And/Or Ovarian Cancer	Breast And Ovarian Cancer Syndrome
Hboc Syndrome	Hereditary Breast And Ovarian Cancer
Brca1- Brca2-Associated Hboc

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Nephronophthisis

Medullary Cystic Disease	Medullary Cystic Kidney
Nph	Nphp
Kidney Disease, Cystic, Medullary

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01397	BCAR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	BCAR1	VGNC	VGNC:38398
Felis catus	BCAR1	VGNC	VGNC:69188
Mus musculus	BCAR1	MGD	MGI:108091
Macaca mulatta	BCAR1	VGNC	VGNC:70234
Rattus norvegicus	BCAR1	RGD	RGD:2406
Bos taurus	BCAR1	VGNC	VGNC:26437

Name
Email *

	Sorry, but the email address you supplied was invalid.