2. Gene
  3. PTP4A2 - protein tyrosine phosphatase 4A2 Gene

PTP4A2 - protein tyrosine phosphatase 4A2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HH13; OV-1; PRL2; HH7-2; PRL-2; PTP4A; HU-PP-1; PTPCAAX2; ptp-IV1a; ptp-IV1b

Gene ID: 8073 | Gene type: protein coding

About PTP4A2

Cytogenetic location: 1p35.2 Genomic coordinates (GRCh38): 1:31,906,421-31,938,368 (from NCBI)

This gene has 20 transcripts (splice variants), 296 orthologues and 8 paralogues. Ubiquitous expression in thyroid (RPKM 58.0), bone marrow (RPKM 56.7) and 25 other tissues.

Summary

The protein encoded by this gene belongs to a small class of the protein tyrosine Phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine Phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]

PTP4A2 Products(6)

mRNA Protein Name
NM_001195100.2 NP_001182029.1 protein tyrosine phosphatase type IVA 2 isoform 3
NM_001195101.2 NP_001182030.1 protein tyrosine phosphatase type IVA 2 isoform 4
NM_001369858.1 NP_001356787.1 protein tyrosine phosphatase type IVA 2 isoform 4
NM_001369859.1 NP_001356788.1 protein tyrosine phosphatase type IVA 2 isoform 1
NM_001369860.1 NP_001356789.1 protein tyrosine phosphatase type IVA 2 isoform 1
NM_080391.4 NP_536316.1 protein tyrosine phosphatase type IVA 2 isoform 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
28330616 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10940933 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTP4A2 Protein Structure

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (58 - 143)

  • 0
  • 100
  • 167 a.a.
Protein Preferred Names Protein Names

protein tyrosine phosphatase type IVA 2

PTP(CAAXII)

PTP4A2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PTP4A2 Q12974 CNNM1 Homo sapiens Q9NRU3
Anti Tag CoIP
33961781
Intra
PTP4A2 Q12974 CNNM1 Homo sapiens Q9NRU3
Validated Y2H
32296183
Intra
PTP4A2 Q12974 CNNM1 Homo sapiens Q9NRU3
BioID
28330616
Intra
PTP4A2 Q12974 CNNM1 Homo sapiens Q9NRU3
Pull Down
28330616
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PTP4A2 Proteins

Cat. No. Product Name Accession Purity
HY-P71245 PTP4A2 Protein, Human (His) Q12974 (M1-Q167) ≥95%
HY-P77169 PTP4A2 Protein, Human (GST) Q12974 (N2-Q167) ≥95%

Related Diseases

Diseases Alias
Ovarian Lymphoma
Centronuclear Myopathy

Myopathy, Centronuclear

Myotubular Myopathy

Cnm

Myopathy, Myotubular

Congenital Structural Myopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-135457 JMS-053 ≥98.0% Unkown
HY-RS11410 PTP4A2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PTP4A2 VGNC VGNC:106477
Rattus norvegicus PTP4A2 RGD RGD:619786
Felis catus PTP4A2 VGNC VGNC:107610
Canis familiaris PTP4A2 VGNC VGNC:45162
Bos taurus PTP4A2 VGNC VGNC:33524
Mus musculus PTP4A2 MGD MGI:1277117
Others PTP4A2 NCBI