EEPD1 - endonuclease/exonuclease/phosphatase family domain containing 1 Gene

Homo sapiens

Also known as HSPC107

Gene ID: 80820 | Gene type: protein coding

About EEPD1

Cytogenetic location: 7p14.2 Genomic coordinates (GRCh38): 7:36,153,254-36,301,538 (from NCBI)

This gene has 5 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in fat (RPKM 7.4), brain (RPKM 4.8) and 23 other tissues.

Summary

Predicted to enable DNA binding activity. Involved in positive regulation of Cholesterol efflux. Is anchored component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

EEPD1 Products(1)

mRNA	Protein	Name
NM_030636.3	NP_085139.2	endonuclease/exonuclease/phosphatase family domain-containing protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of cholesterol efflux	IMP IMP: Inferred from mutant phenotype	28082258	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	28082258	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EEPD1 Protein Structure

HHH_3

Exo_endo_phos

0
100
200
300
400
500
569 a.a.

Protein Preferred Names

Protein Names

endonuclease/exonuclease/phosphatase family domain-containing protein 1

EEPD1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EEPD1	Q7L9B9	GRIP1	Homo sapiens	Q9Y3R0-3	Y2H Prey Pooling	32296183
Intra	EEPD1	Q7L9B9	GRIP1	Homo sapiens	Q9Y3R0-3	Validated Y2H	32296183
Intra	EEPD1	Q7L9B9	GRIP1	Homo sapiens	Q9Y3R0-3	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Meninges Sarcoma

Meningeal Sarcoma	Sarcoma Of Meninges
Meningothelial Sarcoma	Leptomeningeal Sarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04183	EEPD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	EEPD1	VGNC	VGNC:28338
Canis familiaris	EEPD1	VGNC	VGNC:40212
Rattus norvegicus	EEPD1	RGD	RGD:1307401
Felis catus	EEPD1	VGNC	VGNC:61736
Mus musculus	EEPD1	MGD	MGI:1914734
Macaca mulatta	EEPD1	VGNC	VGNC:72085

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