1. Gene
  2. Nfkbiz - nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta Gene

Nfkbiz - nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta Gene

Mus musculus

Also known as INAP; Mail

Gene ID: 80859 | Gene type: protein coding

About Nfkbiz

Summary

Involved in T cell receptor signaling pathway and positive regulation of T-helper 17 cell differentiation. Acts upstream of or within inflammatory response. Located in nucleus. Is expressed in early conceptus; eye; and genitourinary system. Used to study Stevens-Johnson syndrome and atopic dermatitis. Orthologous to human NFKBIZ (NFKB inhibitor zeta). [provided by Alliance of Genome Resources, Apr 2022]

Nfkbiz Products(3)

mRNA Protein Name
NM_001159394.1 NP_001152866.1 NF-kappa-B inhibitor zeta isoform a
NM_001159395.1 NP_001152867.1 NF-kappa-B inhibitor zeta isoform b
NM_030612.3 NP_085115.1 NF-kappa-B inhibitor zeta isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20383124 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
25107474 MGI
enables transcription coregulator activity IDA
IDA: Inferred from direct assay
15618216 MGI
Biological Process GO Annotation Evidence Reference Source
involved in B cell proliferation IMP
IMP: Inferred from mutant phenotype
23728777 MGI
involved in B cell receptor apoptotic signaling pathway IDA
IDA: Inferred from direct assay
23728777 MGI
involved in B cell receptor signaling pathway IDA
IDA: Inferred from direct assay
17367755 MGI
involved in T cell differentiation IMP
IMP: Inferred from mutant phenotype
26019294 MGI
involved in T cell mediated immunity IMP
IMP: Inferred from mutant phenotype
31182790 MGI
involved in T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
25282160 MGI
involved in T-helper 1 cell differentiation IMP
IMP: Inferred from mutant phenotype
31182790 MGI
involved in T-helper 17 cell differentiation IMP
IMP: Inferred from mutant phenotype
20383124 MGI
involved in adaptive immune response IDA
IDA: Inferred from direct assay
17367755 MGI
involved in cell growth IMP
IMP: Inferred from mutant phenotype
28740238 MGI
involved in cellular response to cytokine stimulus IDA
IDA: Inferred from direct assay
32144162 MGI
involved in cellular response to cytokine stimulus IMP
IMP: Inferred from mutant phenotype
26460049 MGI
involved in cellular response to interleukin-17 IDA
IDA: Inferred from direct assay
31853061 MGI
involved in cellular response to interleukin-17 IMP
IMP: Inferred from mutant phenotype
31164412 MGI
involved in cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
27129283 MGI
involved in cellular response to transforming growth factor beta stimulus IMP
IMP: Inferred from mutant phenotype
26019294 MGI
involved in chemokine production IMP
IMP: Inferred from mutant phenotype
15491998 MGI
involved in chromatin organization IMP
IMP: Inferred from mutant phenotype
18319258 MGI
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
27129283 MGI
involved in chromatin remodeling IMP
IMP: Inferred from mutant phenotype
27129283 MGI
involved in chronic inflammatory response IMP
IMP: Inferred from mutant phenotype
31853061 MGI
involved in cytokine production IMP
IMP: Inferred from mutant phenotype
28740238 MGI
involved in cytokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
30224457 MGI
involved in defense response to Gram-negative bacterium IMP
IMP: Inferred from mutant phenotype
31182790 MGI
involved in epithelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
23453632 MGI
involved in establishment of skin barrier IMP
IMP: Inferred from mutant phenotype
28740238 MGI
involved in execution phase of apoptosis IMP
IMP: Inferred from mutant phenotype
26776679 MGI
involved in gene expression IDA
IDA: Inferred from direct assay
15618216 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
15491998 MGI
involved in homeostasis of number of cells within a tissue IMP
IMP: Inferred from mutant phenotype
26019294 MGI
involved in immunoglobulin mediated immune response IMP
IMP: Inferred from mutant phenotype
25124037 MGI
involved in immunoglobulin production IMP
IMP: Inferred from mutant phenotype
15491998 MGI
involved in immunoglobulin production involved in immunoglobulin-mediated immune response IMP
IMP: Inferred from mutant phenotype
18441309 MGI
acts upstream of or within inflammatory response IDA
IDA: Inferred from direct assay
11086164 MGI
involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
15491998 MGI
involved in inflammatory response to wounding IDA
IDA: Inferred from direct assay
26776679 MGI
involved in interleukin-10 production IMP
IMP: Inferred from mutant phenotype
27129283 MGI
involved in isotype switching IMP
IMP: Inferred from mutant phenotype
25124037 MGI
involved in keratinocyte activation IMP
IMP: Inferred from mutant phenotype
15491998 MGI
involved in keratinocyte differentiation IMP
IMP: Inferred from mutant phenotype
26460049 MGI
involved in keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
26460049 MGI
involved in lymphocyte activation involved in immune response IMP
IMP: Inferred from mutant phenotype
23453632 MGI
involved in mRNA transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
27129283 MGI
involved in mRNA transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
27129283 MGI
involved in plasma cell differentiation IMP
IMP: Inferred from mutant phenotype
25124037 MGI
involved in positive regulation of T-helper 17 cell differentiation IMP
IMP: Inferred from mutant phenotype
25282160 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
27129283 MGI
involved in regulation of immune response IMP
IMP: Inferred from mutant phenotype
26019294 MGI
involved in response to Gram-positive bacterium IMP
IMP: Inferred from mutant phenotype
28740238 MGI
involved in response to cisplatin IDA
IDA: Inferred from direct assay
26776679 MGI
involved in response to cytokine IMP
IMP: Inferred from mutant phenotype
26776679 MGI
involved in response to folic acid IDA
IDA: Inferred from direct assay
26776679 MGI
involved in response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
26776679 MGI
involved in response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
31622280 MGI
involved in skin development IMP
IMP: Inferred from mutant phenotype
15491998 MGI
involved in skin epidermis development IMP
IMP: Inferred from mutant phenotype
15491998 MGI
involved in spleen development IMP
IMP: Inferred from mutant phenotype
31182790 MGI
involved in toll-like receptor signaling pathway IDA
IDA: Inferred from direct assay
23728777 MGI
involved in toll-like receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
23728777 MGI
involved in transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20383124 MGI
involved in transcription preinitiation complex assembly IMP
IMP: Inferred from mutant phenotype
18319258 MGI
involved in type II interferon production IMP
IMP: Inferred from mutant phenotype
26019294 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in nucleus IDA
IDA: Inferred from direct assay
15618216 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11086164 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NF-kappa-B inhibitor zeta

I-kappa-B-zeta

IL-1 inducible nuclear ankyrin-repeat protein

IkappaB-zeta

ikB-zeta

ikappaBzeta

molecule possessing ankyrin-repeats induced by lipopolysaccharide

Nfkbiz Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Nfkbiz Q9EST8 Akirin2 Mus musculus B1AXD8 25107474
Intra
Nfkbiz Q9EST8 Akirin2 Mus musculus B1AXD8 25107474
Cross: Cross-species interaction Intra: Intraspecies interaction

Orthologs Information

Species Symbol Source ID
Homo sapiens Nfkbiz NCBI NCBI:64332