EGFL8 - EGF like domain multiple 8 Gene

Homo sapiens

Also known as NG3; C6orf8

Gene ID: 80864 | Gene type: protein coding

About EGFL8

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,164,595-32,168,281 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 83 orthologues and 5 paralogues. Ubiquitous expression in ovary (RPKM 13.7), skin (RPKM 12.8) and 25 other tissues.

Summary

Predicted to enable signaling receptor binding activity. Predicted to be involved in anatomical structure development. Predicted to act upstream of or within in utero embryonic development. Predicted to be active in cell surface and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

EGFL8 Products(1)

mRNA	Protein	Name
NM_030652.4	NP_085155.1	epidermal growth factor-like protein 8 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EGFL8 Protein Structure

EMI

EGF

EGF_CA

0
100
200
293 a.a.

Protein Preferred Names

Protein Names

epidermal growth factor-like protein 8

EGF-like protein 8

EGFL8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EGFL8	Q99944	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	EGFL8	Q99944	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	EGFL8	Q99944	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	EGFL8	Q99944	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
Intra	EGFL8	Q99944	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
Intra	EGFL8	Q99944	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
Intra	EGFL8	Q99944	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	EGFL8	Q99944	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	EGFL8	Q99944	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	EGFL8	Q99944	F13A1	Homo sapiens	P00488	Validated Y2H	32814053
Intra	EGFL8	Q99944	F13A1	Homo sapiens	P00488	Y2H Pooling	32814053
Intra	EGFL8	Q99944	DLST	Homo sapiens	P36957	Y2H Array	32814053
Intra	EGFL8	Q99944	DLST	Homo sapiens	P36957	Y2H Pooling	32814053
Intra	EGFL8	Q99944	DLST	Homo sapiens	P36957	Validated Y2H	32814053
Intra	EGFL8	Q99944	HSPD1	Homo sapiens	P10809	Y2H Array	32814053
Intra	EGFL8	Q99944	HSPD1	Homo sapiens	P10809	Validated Y2H	32814053
Intra	EGFL8	Q99944	HSPD1	Homo sapiens	P10809	Y2H Pooling	32814053
Intra	EGFL8	Q99944	CRYAA	Homo sapiens	P02489	Y2H Array	32814053
Intra	EGFL8	Q99944	CRYAA	Homo sapiens	P02489	Y2H Pooling	32814053
Intra	EGFL8	Q99944	CRYAA	Homo sapiens	P02489	Validated Y2H	32814053
Intra	EGFL8	Q99944	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	EGFL8	Q99944	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053
Intra	EGFL8	Q99944	PECAM1	Homo sapiens	P16284	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ludwig'S Angina

Cellulitis Of Floor Of Mouth

Ludwig Angina

Latent Syphilis

Syphilis, Latent

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04207	EGFL8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	EGFL8	VGNC	VGNC:40238
Felis catus	EGFL8	VGNC	VGNC:61757
Bos taurus	EGFL8	VGNC	VGNC:28365
Mus musculus	EGFL8	MGD	MGI:1932094
Rattus norvegicus	EGFL8	RGD	RGD:1549706

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